A5018044421- Virology and Viral Diseases
- Viral Infections and Vectors
- Parvovirus B19 Infection Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- HIV Research and Treatment
- Long-Term Effects of COVID-19
- Cancer, Hypoxia, and Metabolism
- Zoonotic diseases and public health
- interferon and immune responses
- Cancer, Stress, Anesthesia, and Immune Response
- Neuropeptides and Animal Physiology
- Adipose Tissue and Metabolism
- Thermoregulation and physiological responses
- Regulation of Appetite and Obesity
- Epigenetics and DNA Methylation
- Syphilis Diagnosis and Treatment
- Viral Infections and Immunology Research
- COVID-19 Clinical Research Studies
Université Claude Bernard Lyon 1
2018-2025
Centre International de Recherche en Infectiologie
2018-2025
Inserm
2018-2025
Centre National de la Recherche Scientifique
2018-2024
École Normale Supérieure de Lyon
2018-2024
Cedars-Sinai Medical Center
2020
Measles virus (MeV) infection can cause serious complications in immunocompromised individuals, including measles inclusion body encephalitis (MIBE). In some cases, MeV persistence and subacute sclerosing panencephalitis (SSPE), another severe central nervous system (CNS) complication, develop even the face of a systemic immune response.
Abstract The Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging pathogen of the Orthonairovirus genus that can cause severe and often lethal diseases in humans. CCHFV has a broad tropism infect variety species tissues. Here, by using gene silencing, blocking antibodies or soluble receptor fragments, we identify low-density lipoprotein (LDL-R) as entry factor. LDL-R facilitates binding particles but does not allow Hazara (HAZV), another member genus. In addition, show apolipoprotein...
During a measles virus (MeV) epidemic in 2009 South Africa, inclusion body encephalitis (MIBE) was identified several HIV-infected patients. Years later, children are presenting with subacute sclerosing panencephalitis (SSPE). To investigate the features of established MeV neuronal infections, viral sequences were analyzed from brain tissue samples single SSPE case and compared MIBE previously obtained patients infected during same epidemic. Both viruses had amino acid substitutions...
Abstract The Hendra and Nipah viruses (HeV NiV) are zoonotic biosafety level-4 pathogens within the Paramyxoviridae family. We previously showed that their W proteins form amyloid-like fibrils in vitro . Here, we demonstrate also forms cellula cysteine residues crucial dictating ability of to fibrillate. oxidation state acts as a switch generate either amorphous aggregates or flexible fibrils. Ectopic expression HeV induces an oxidative stress were observed nuclei different cell lines, with...
Abstract The hypoxia response pathway enables adaptation to oxygen deprivation. It is mediated by hypoxia-inducible factors (HIF), which promote metabolic reprogramming, erythropoiesis, angiogenesis and tissue remodeling. This led the successful development of HIF-inducing drugs for treating anemia some these molecules are now in clinic. However, elevated levels HIFs frequently associated with tumor growth, poor prognosis, drug resistance various cancers, including hepatocellular carcinoma...
Calcitonin Gene-Related Peptide α (CGRPα) is a multifunctional neuropeptide found in the central and peripheral nervous system with cardiovascular, nociceptive, gastrointestinal activities. CGRPα has been linked to obesity insulin secretion but role of this circulating peptide energy metabolism remains unclear. Here, we thought utilize monoclonal antibody against assess its ability improve glucose homeostasis mouse models hyperglycemia diabetes. We examined outcome anti-CGRPα treatment...
Patients on maintenance hemodialysis (MHD) are at high risk of both infection by SARS-CoV-2 and death from COVID-19,1 justifying the early prioritization this vulnerable population for vaccination. It is widely accepted that protection induced vaccination against symptomatic COVID-19 , in general population2 immunocompromised patients,3 due to neutralizing antibodies. Cellular immunity, which able limit severe absence antibodies, appears be a second step immune protection,.
The cessation of measles virus (MeV) vaccination in more than 40 countries as a consequence the COVID-19 pandemic is expected to significantly increase deaths due measles. MeV can infect central nervous system (CNS) and lead lethal encephalitis. Substantial part sequences recovered from patients' brain were mutated matrix and/or fusion protein (F). Mutations heptad repeat domain located C terminal (HRC) F often observed associated hyperfusogenicity. These mutations promote invasion hallmark...
The Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne bunyavirus that causes high mortality in humans with wide geographic range. This enveloped has tri-segmented negative or ambisense RNA genome harbors two surface glycoproteins (GP), Gn and Gc. maturation of the Gn/Gc glycoprotein precursor complex takes place ER completed through secretion pathway. Here, we aimed at characterizing trafficking network exploited by CCHFV GPs during stages assembly, envelopment, and/or egress. We...
Sensory neurons arising from the dorsal root ganglia play a pivotal role in thermoregulation through detection of cutaneous temperature and transmission sensory signals to brain. However, functional significance perception thermogenesis weight loss has remained elusive. Here, we show that genetic ablation heat sensing containing Calcitonin Gene-Related Peptide (CGRPα) promotes resistance gain upon high fat diet (HFD) feeding drives thermogenic program brown white adipose tissues. Remarkably,...