A5102749394- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Dementia and Cognitive Impairment Research
- Craniofacial Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Liver Disease Diagnosis and Treatment
- Cerebrovascular and genetic disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- History and Developments in Astronomy
- Cervical and Thoracic Myelopathy
- Astronomy and Astrophysical Research
- Genetic and Kidney Cyst Diseases
- Neurobiology of Language and Bilingualism
- Child Abuse and Related Trauma
- Ginseng Biological Effects and Applications
- Autoimmune Neurological Disorders and Treatments
- Diet, Metabolism, and Disease
- Cerebral Venous Sinus Thrombosis
- Neurosurgical Procedures and Complications
- Hepatitis B Virus Studies
- Vitamin D Research Studies
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
Kangbuk Samsung Hospital
2011-2023
Sungkyunkwan University
2012-2023
Korea Institute of Toxicology
2007-2023
International Ginseng & Herb Research Institute
2018
Neurology, Inc
2009-2015
Inje University Haeundae Paik Hospital
2014
Chung-Ang University Hospital
2014
Inje University
2014
Hanyang University Seoul Hospital
2012
Soongsil University
2012
<b><i>Background:</i></b> Low 25-hydroxyvitamin D (25(OH)D) concentrations have been shown to predict risk of cardiovascular disease and all-cause mortality. Although the prevalence 25(OH)D deficiency is high in patients with acute stroke, prognostic value stroke has not clearly established. The purpose this study was determine whether baseline serum level associated functional outcome ischemic stroke. <b><i>Methods:</i></b> From June 2011...
Background and Purpose— The aim of this study was to determine the association between 25-hydroxyvitamin D (25(OH)D) neuroimaging correlates cerebral small vessel disease. Methods— We identified 759 consecutive patients with acute ischemic stroke or transient attack. Lacunes, white matter hyperintensity, microbleed (CMB) were assessed using MR images. Deep CMB defined as presence in basal ganglia, thalamus, brain stem. 25(OH)D disease tested linear logistic regression analyses. Results— Mean...
Although subtle discourse declines in people with mild cognitive impairment (MCI) have been reported, heterogeneous measures and tasks among the MCI studies yielded widely varying outcomes. The present study aimed to first, identify that aid differentiation amnestic (aMCI), non-amnestic (naMCI), cognitively healthy control (HC) participants, second, delineate functions related such measures. Three (an episodic narrative, a planning task, picture description) were performed by 30 aMCI, 22...
Our aim was to investigate the distribution pattern of cerebral artery calcification and its association with white matter hyperintensities (WMH).We identified 159 consecutive patients acute ischemic stroke. Calcifications arteries WMH were graded.Cerebral found in 137 (86.2%). The intracranial internal carotid (I-ICA) most frequently affected (76.7%) moderate-to-severe (38.1%). Spearman's rank test revealed that grade I-ICA correlated those periventricular (r = 0.417, p < 0.001) deep 0.388,...
Subclinical hypothyroidism (SCH) is thought to have an influence on stroke outcomes. However, few reports demonstrate a favorable relationship between the two. We evaluated this association in acute ischemic stroke. From Jan 2005 June 2008, 756 patients were recruited within seven days of onset. The with overt hypothyroidism/hyperthyroidism or other medical conditions that may affect thyroid function excluded. Thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels measured two...
<b><i>Background/Aims:</i></b> An increase in the pulsatility index (PI) has been suggested to reflect distal vascular resistance. The purpose of present study was investigate association between intracranial arterial calcification and PIs. <b><i>Methods:</i></b> Consecutive patients with acute ischemic stroke or transient attack were included. PIs both middle cerebral arteries (MCAs) measured by transcranial Doppler ultrasonography....
Metabolic syndrome (MetS) is a risk factor for cardiovascular disease (CVD) mortality.This study aimed to evaluate the association of MetS with all-cause and mortality in apparently healthy young Korean subjects.A retrospective 155,971 participants (mean age, 41.8 y) health screening program, followed up 3.7 years (597,628.2 person-years). The CVD were analyzed according presence or absence MetS.A total 542 subjects died during followup. Women showed significantly increased age-adjusted...
Background and Purpose: Intracranial atherosclerosis (ICAS) is one of the major risk factors for ischemic stroke, particularly in Asian populations.We investigated prevalence ICAS asymptomatic subjects.Methods: We prospectively evaluated 835 Korean adults who voluntarily visited a tertiary referral hospital health screening examination that included brain magnetic resonance angiography.The subjects had no history stroke or transient attacks; those potential cardiac sources emboli were...
<i>Background/Aims:</i> Vascular calcification is known to be associated with cardiovascular mortality, and arterial stiffness measured by pulse wave velocity major risk factors. The aim of the present study was elucidate correlation between cerebral calcification. <i>Methods:</i> Arterial stiffness, as brachial-ankle (baPWV), calcification, CT angiography using a 40-multidetector scanner, were examined in patients acute ischemic stroke. Sixty-seven subjects who free...
Leukoaraiosis (LA) is associated with aging and vascular risk factors, a factor of intracerebral hemorrhage (ICH) after treatment warfarin or thrombolytic for ischemic stroke. In this study, we sought to examine whether LA predictor outcome spontaneous ICH.We retrospectively analyzed 238 consecutive patients supratentorial ICH identified by database search. Patients were divided into two groups according neurological at 90 days: good outcomes (Glasgow Outcome Scale ≥4) poor outcomes....
Human IgG1 Fc has been widely used as a bioconjugate, but exhibits shortcomings, such antibody- and complement-mediated cytotoxicity well decreased bioactivity, when applied to agonistic proteins. Here, we constructed nonimmunogenic, noncytolytic flexible hybrid (hyFc) consisting of IgD IgG4, tested its function using erythropoietin (EPO) conjugate, EPO-hyFc. Despite low amino acid homology (20.5%) between IgG4 Fc, EPO-hyFc retained "Y-shaped" structure repeated intravenous administrations...
We analyzed serologic data that were obtained from the Korea Association of Health 1995 to 1999 estimate reliable prevalence HBV in South Korea.603,375, 639,465, 621,476, 612,705 and 650,398 serum samples annually tested for HBsAg. Of HBsAg positive persons whose available, HBeAg positivity was checked.HBsAg positivities among subjects between 6 19 years old 8.2%, 3.9%, 2.1%, 2.6% 1.3%. above 20 8.9%, 6.4%, 5.9%, 5.4% 5.4%. The rates 39.8 62.9% old, 18.3 37.9% each year. In both subgroups,...
<i>Background:</i> Previous diffusion-weighted MRI (DWI) studies have indicated that 10–40% of patients silent embolism during neurointerventional procedures. However, lesion patterns the embolisms not been adequately investigated. <i>Methods:</i> DWI was taken within 7 days before and 48 h after cerebral angioplasty stent New lesions on follow-up were analyzed in non-treated arterial territories. Based territories, supratentorial classified into cortical subcortical...
It is difficult to clarify whether small deep infarction caused by cardioembolism or intrinsic vessel disease in patients with atrial fibrillation (AF). The purpose of this study was determine preexisting would differ according the presenting infarct pattern and factors associated acute single stroke AF.Between January 2008 August 2012, 1,592 consecutive ischemic within 7 days symptom onset were entered a prospectively maintained registry. For present study, 231 AF enrolled irrespective...
Objectives. We attempted to determine the propensity for sidedness of cardiogenic emboli associated with atrial fibrillation (AF) by comparing sides on which microembolic signals (MES) were detected via transcranial Doppler (TCD) monitoring and location infarcts magnetic resonance imaging. Design. Patients AF Holter MES TCD selected from an ischemic stroke registry. prosthetic valves or cerebral/carotid artery stenosis excluded. Results. By 30 patients, 78 detected: 47 right 31 left side...
Objective Park system is a magnetic resonance imaging (MRI) grading for cervical neural foraminal stenosis (CNFS) and consists of 4 grades (0–3) based on the shape 45-degree T2-weighted oblique sagittal images. The objective this study was to evaluate interreader reliability among radiologists, residents, clinicians. This also assessed correlations between radiologic clinical findings. Material Methods A total 289 patients (men:women = 155:134, mean age 50 years) who underwent MRI spine at...
To investigate the clinical features and outcome of outpatient-based physiotherapy (manual stretch) congenital muscular torticollis (CMT) with passive neck motion limitation (≥ 10°) according to whether finding on ultrasonography (US) is normal or abnormal.Case-control study.Institutional practice.A total 149 patients CMT who met eligibility criteria were included: age at presentation ≤ 6 months, rotation (ΔROT) lateral flexion (ΔLAT) ≥ 10°, completion our program.Patients allocated...