A5056777056- Cardiovascular Health and Disease Prevention
- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Peripheral Artery Disease Management
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Pharmacology and Obesity Treatment
- Cerebrovascular and Carotid Artery Diseases
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Diabetes Treatment and Management
- Cholesterol and Lipid Metabolism
- Nutritional Studies and Diet
- Body Contouring and Surgery
- Antioxidant Activity and Oxidative Stress
- Gastric Cancer Management and Outcomes
- Hormonal Regulation and Hypertension
- Heart Rate Variability and Autonomic Control
Toho University
2016-2025
Toho University Medical Center Sakura Hospital
2016-2025
Toho University Ohashi Medical Center
2023
Tomitahama Hospital
2023
Chiba Kaihin Municipal Hospital
2023
Diabetes Australia
2006-2016
We investigated whether cardio-ankle vascular index (CAVI), an arterial stiffness marker, independently predicts future cardiovascular events in subjects with metabolic disorders.1562 outpatients underwent CAVI between April 2004 and March 2006 at Toho University, Sakura Medical Center Chiba, Japan. Patients who already had baseline, patients low ankle brachial (＜0.9), atrial fibrillation were excluded. After exclusion, 1080 disorders including diabetes mellitus, hypertension dyslipidemia...
Resveratrol has been reported to have potent anti-atherosclerotic effects in animal studies. However, there are few interventional studies human patients with atherosclerogenic diseases. The cardio-ankle vascular index (CAVI) reflects arterial stiffness and is a clinical surrogate marker of atherosclerosis. aim the present study was investigate effect resveratrol on assessed by CAVI type 2 diabetes mellitus (T2DM).
Background Arterial stiffness is an important predictor of cardiovascular events; however, indexes for measuring arterial have not been widely incorporated into routine clinical practice. This study aimed to determine whether the cardio-ankle vascular index (CAVI), based on blood pressure-independent parameter β and reflecting from origin ascending aorta, a good events in patients with disease risk factors large prospective cohort. Methods Results multicenter cohort study, commencing May...
Aim: A novel device has been developed for measuring the cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness. In this study, we evaluated effect pitavastatin on CAVI in type 2 diabetic patients.Methods: Forty-five diabetes mellitus patients with low-density lipoprotein cholesterolemia were enrolled and treated mg/day 12 months. Before after administration, HbA1c, serum lipids, malondialdehyde-LDL (MDA-LDL), urinary 8-hydroxy- 2'-deoxyguanosine (8-OHdG) measured.Results:...
Aims: Glimepiride, a third generation sulfonylurea (SU), is known to have extrapancreatic effects, but its vascular effect unclear. We investigated the efficacy of glimepiride in improving arterial stiffness assessed by cardio-ankle index (CAVI) type 2 diabetic patients, compared with glibenclamide, conventional SU. Methods: Forty patients were randomly assigned two groups. One group was administered 1.5 mg/day, and other glibenclamide 1.25 mg/day for 6 months. Results: No significant...
Aim: Recently, a novel device for measuring the cardio-ankle vascular index (CAVI) as an arterial stiffness parameter has been developed. In this study, we evaluated effect of angiotensin II receptor blocker (ARB) and calcium channel (Ca) on CAVI in type 2 diabetic patients with hypertension.Methods: Seventy diabetes mellitus hypertension were enrolled randomly divided into two groups. One group was administered olmesartan medoxomil 10 mg/day 12 months (ARB group), other amlodipine besilate...
The objective of this study is to investigate the association body mass index (BMI) with arterial stiffness assessed by cardioankle vascular (CAVI).A retrospective cross-sectional was conducted in 23,257 healthy Japanese subjects (12,729 men and 10,528 women, aged 47.1 ± 12.5 years, BMI 22.9 3.4 kg/m2) who underwent health screening between 2004 2006 Japan. Exclusion criteria were current medication use a past history cardiovascular disease, hypertension, stroke, diabetes, nephritis.Male...
A body shape index (ABSI) is an abdominal obesity developed based on epidemiological statistics and designed to correlate minimally with mass (BMI). We examined the approximation between ABSI other indices biophysical concepts. The cross-sectional data from 62,514 Japanese urban residents were analyzed. Body adiposity comprising BMI, waist circumference (WC), ABSI, conicity (CI), waist-to-height ratio (WHtR), WC/BMI examined. CI more strongly correlated age arterial stiffness assessed by...
Glucagon-like peptide (GLP)-1 analogue may be useful for controlling weight recurrence and diabetes relapse after bariatric surgery, but also adversely affect the measured nutritional metrics. This study aimed to investigate effect of treatment with once-weekly semaglutide laparoscopic sleeve gastrectomy (LSG) in patients type 2 (T2D). We examined effects combined use a low-energy, high-protein formula diet (FD).
Aim: The three types of calcium channel blocker (CCB), L-, T- and N-type, possess heterogeneous actions on endothelial function renal microvascular function. In the present study, we evaluated effects two CCBs, efonidipine amlodipine, arterial stiffness.Methods: Forty type 2 diabetic patients with hypertension nephropathy receiving angiotensin receptor II blockers were enrolled randomly divided into groups: group was administered hydrochloride ethanolate 40 mg/day amlodipine admin-istered...
We aimed to investigate the effect of resveratrol (Rsv) on expression genes regulating triglyceride (TG) accumulation and consumption in differentiated 3T3-L1 preadipocytes. preadipocytes were cultured DMEM supplemented with 10% fetal calf serum. Upon reaching confluence, cells induced differentiate for 4 days, 10 days TG accumulation, then incubated Rsv (0, 25 or 50 μM) 3 days. was analyzed by Oil Red-O staining. To understand how regulates consumption, changes gene protein expressions...
To investigate the associations of conventional lipid parameters with arterial stiffness assessed by cardio-ankle vascular index (CAVI).
Abstract Aim Laparoscopic sleeve gastrectomy ( LSG ) is becoming popular in Japan, but insufficient weight loss often observed patients after . We investigated the effect of on obesity‐related comorbidities and identified background characteristics Japanese with Methods In this multi‐institutional retrospective study at 10 certified bariatric institutions, 322 who underwent a follow‐up period more than 2 years were analyzed. Anthropometry, psychosocial data collected. Weight was expressed as...
Abdominal obesity as a risk factor for diagnosing metabolic syndrome (MetS) is evaluated using waist circumference (WC), although WC does not necessarily reflect visceral adiposity. This cross-sectional study aimed to clarify whether replacing with "A Body Shape Index (ABSI)," an abdominal index, in MetS diagnosis detects individuals arterial stiffening assessed by cardio-ankle vascular index (CAVI).A retrospective was conducted 46,872 Japanese urban residents (median age 40 years) who...
The relative usefulness of arterial stiffness parameters on renal function remains controversial. This study aimed to compare the predictive ability three at baseline; cardio-ankle vascular index (CAVI), heart-ankle pulse wave velocity (haPWV) and CAVI 0 , a variant that theoretically excludes dependence blood pressure, for decline in Japanese general population.A total 27 864 urban residents without impairment baseline who participated two eight consecutive (mean 3.5 ± 1.7 times) annual...