A5019329037- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Natural product bioactivities and synthesis
- Mitochondrial Function and Pathology
- Systemic Lupus Erythematosus Research
- Essential Oils and Antimicrobial Activity
- Cancer Treatment and Pharmacology
- Malaria Research and Control
- Immune Cell Function and Interaction
- Phytochemistry and Biological Activities
- Mosquito-borne diseases and control
- Silymarin and Mushroom Poisoning
- Pain Mechanisms and Treatments
Universidade Federal do Rio de Janeiro
2016-2024
Hospital Universitário Antônio Pedro
2018-2020
Universidade Federal Fluminense
2017-2020
Kalanchoe daigremontiana (Crassulaceae) is a medicinal plant native to Madagascar. The aim of this study was investigate the flavonoid content an aqueous leaf extract from K. (Kd), and assess its antiherpetic potential. major flavonoid, kaempferol 3-O-β-d-xylopyranosyl-(1 → 2)-α-l-rhamnopyranoside (1), isolated AcOEt fraction (Kd-AC). BuOH-soluble afforded quercetin (2) new 2)-α-l-rhamnopyranoside-7-O-β-d-glucopyranoside (3), named daigremontrioside. crude extract, Kd-AC fraction, flavonoids...
This study aimed at analyzing circulating levels of inflammatory and profibrogenic cytokines in patients with hepatitis C virus (HCV) chronic infection undergoing therapy direct-acting antiviral agents (DAA) correlating these immune biomarkers liver disease status. We studied 88 Brazilian monoinfected receiving interferon- (IFN-) free sofosbuvir-based regimens for 12 or 24 weeks, followed-up before initiation three months after the end treatment. Liver was determined by transient...
Dengue virus (DENV) infection is known to affect host cell metabolism, but the molecular players involved are still poorly known. Using a proteomics approach, we identified six DENV proteins associated with mitochondria isolated from infected hepatocytes, and most of peptides were NS3. We also found an at least twofold decrease several electron transport system (ETS) proteins. Thus, investigated whether NS3 could modulate ETS function by incubating recombinant constructs in mouse liver. that...
Sofosbuvir(SOF)-based regimens have been administrated with excellent efficacy in chronic hepatitis C. Few uncontrolled ("real-life") studies consider the assessment of renal function when evaluating their post-treatment outcomes. This study aims to evaluate biomarkers a "real-life" experience C patients treated SOF therapy long-term follow-up.Serum and urinary were analysed before, at end (EoT), after 12 weeks (sustained virological response-SVR) one year (1y) post-treatment. Patients...