Bryan M. McCauley
A5016619083- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Ferroptosis and cancer prognosis
- Liver Diseases and Immunity
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Genetic Associations and Epidemiology
- Pediatric Hepatobiliary Diseases and Treatments
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Breast Lesions and Carcinomas
- Gene expression and cancer classification
- Gallbladder and Bile Duct Disorders
- Cancer Research and Treatments
- Breast Cancer Treatment Studies
- Endometrial and Cervical Cancer Treatments
- Advanced Biosensing Techniques and Applications
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Blood Coagulation and Thrombosis Mechanisms
- Renal cell carcinoma treatment
- Atherosclerosis and Cardiovascular Diseases
Mayo Clinic in Arizona
2017-2025
Mayo Clinic
2016-2025
Mayo Clinic in Florida
2017-2024
University of Illinois Urbana-Champaign
2022
WinnMed
2022
Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns TILs by histotype and relation to other clinical factors.
Improved methods are needed to risk stratify and predict outcomes in patients with primary sclerosing cholangitis (PSC). Therefore, we sought derive validate a prediction model compare its performance existing surrogate markers. The was derived using 509 subjects from multicenter North American cohort validated an international (n = 278). Gradient boosting, machine‐based learning technique, used create the model. endpoint hepatic decompensation (ascites, variceal hemorrhage, or...
Altered bile acid (BA) homeostasis is an intrinsic facet of cholestatic liver diseases, but clinical usefulness plasma BA assessment in primary sclerosing cholangitis (PSC) remains understudied. We performed profiling a large retrospective cohort patients with PSC and matched healthy controls, hypothesizing that profiles vary among have utility.Plasma was the Clinical Biochemical Genetics Laboratory at Mayo Clinic using mass spectrometry based assay. Cox proportional hazard (univariate)...
PTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade (LGSOC)). We aimed to characterise expression as biomarker epithelial large population-based study.
Abstract Our objective was to test whether p53 expression status is associated with survival for women diagnosed the most common ovarian carcinoma histotypes (high‐grade serous [HGSC], endometrioid [EC], and clear cell [CCC]) using a large multi‐institutional cohort from Ovarian Tumor Tissue Analysis (OTTA) consortium. assessed on 6,678 cases represented tissue microarrays 25 participating OTTA study sites previously validated immunohistochemical (IHC) assay as surrogate presence functional...
Abstract Background Primary sclerosing cholangitis (PSC) patients have a risk of developing cholangiocarcinoma (CCA). Establishing predictive models for CCA in PSC is important. Methods In large cohort 1,459 seen at Mayo Clinic (1993–2020), we quantified the impact clinical/laboratory variables on development using univariate and multivariate Cox predicted statistical artificial intelligence (AI) approaches. We explored plasma bile acid (BA) levels’ power (subset 300 patients, BA cohort)....
Two important questions regarding the genetics of pancreatic adenocarcinoma (PDAC) are 1. Which germline genetic variants influence incidence this cancer; and 2. Whether PDAC causally predisposes to associated non-malignant phenotypes, such as type 2 diabetes (T2D) venous thromboembolism (VTE).
Abstract Background: Breast cancer (BC) remains a leading health concern worldwide and is often undetected until it metastasizes, limiting treatment options worsening prognosis. Early detection of molecular immune markers in benign breast disease (BBD) could identify women at elevated risk developing invasive, node-positive BC, enabling targeted surveillance prevention efforts. Building on this premise, we investigated the landscape BBD biopsies preceding BC development to enhance...
Abstract Introduction: Fibroadenoma is the most common type of benign breast lesion and not traditionally considered an indicator increased cancer risk. This study aimed to identify biomarkers within fibroadenoma associated with subsequent development using patient samples from Mayo Clinic Benign Breast Disease (BBD) cohort. Methods: We analyzed formalin-fixed paraffin-embedded (FFPE) biopsy patients diagnosed non-proliferative who either developed later (n=10) or remained cancer-free (n=5)....
Abstract Background: The tumor microenvironment (TME) plays a pivotal role in ovarian cancer (OC) progression and prognosis, while also contributing to biological differences between primary metastatic tumors. This study examines OC TMEs uncover associations with clinical prognosis biology by analyzing paired tumors from the same patients. Methods: focused on 57 stage-IIIC/IV patients treated at Mayo Clinic, all of whom underwent surgical debulking adjuvant therapies. All provided informed...
Abstract Introduction: Pseudoangiomatous stromal hyperplasia (PASH) is a benign breast lesion characterized by myofibroblast accumulation. While most women with PASH do not develop cancer, subset eventually does, often in the same where was originally diagnosed, even after surgical removal of lesion. This pattern suggests presence field effect, alterations microenvironment extend beyond itself, potentially influencing neighboring tissue. study aims to identify specific fibroblasts within...
Summary To identify novel single nucleotide polymorphisms (SNPs) associated with venous thromboembolism (VTE) in African-Americans (AAs), we performed a genome-wide association study (GWAS) of VTE AAs using the Electronic Medical Records and Genomics (eMERGE) Network, comprised seven sites each DNA biobanks (total ~39,200 unique samples) SNP data (imputed to 1000 Genomes Project cosmopolitan reference panel) linked electronic health records (EHRs). Using validated EHR-driven phenotype...
ObjectiveTo evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, overall survival.Patients MethodsWe conducted centralized immunohistochemical staining, semi-quantitative scoring, survival analysis 5263 patients participating the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, December 31, 2014, including 2865...
Abstract Background & Aims Primary biliary cirrhosis ( PBC ) is characterized by chronic cholestasis and disease‐specific antimitochondrial antibodies AMA ). A high prevalence of s in first‐degree relatives FDR s) probands has been reported, although the natural history such patients not described. We aimed to assess risk developing + with . Methods First‐degree recruited Mayo Clinic Genetic Epidemiology Registry Biorepository were followed for disease onset after recruitment....
Abstract Background: Ovarian clear cell carcinoma (OCCC) is a rare ovarian cancer histotype that tends to be resistant standard platinum-based chemotherapeutics. We sought better understand the role of DNA methylation in clinical and biological subclassification OCCC. Methods: interrogated genome-wide using from fresh frozen tumors 271 cases, applied nonsmooth nonnegative matrix factorization (nsNMF) clustering, evaluated associations pathways. Results: Two approximately equally sized...
Primary sclerosing cholangitis (PSC) typically develops in middle-age adults. Little is known about phenotypic differences when PSC diagnosed at various ages. Therefore, we sought to compare the clinical characteristics of a large cohort based on age was diagnosed.We performed multicenter retrospective review features among those between 1-19 (n = 95), 20-59 662), and 60-79 years 102).Those with an early diagnosis (ED) were more likely have small-duct (13%) than (MD) (5%) late (LD) groups...
Failure of immunologic homeostasis and resultant hepatocyte destruction in autoimmune hepatitis (AIH) is likely the result environmental triggers within a permissive genetic architecture.We aimed to identify risk factors associated with AIH well-phenotyped cohort.We prospectively collected questionnaires from 358 cases 563 healthy controls. Response frequencies were compared using logistic regression, adjusting for age at recruitment, sex education.AIH more ever have urinary tract infection...
Background: The epigenome, the set of modifications to DNA and associated molecules that control gene expression, cellular identity, function, plays a major role in mediating responses outside factors. Thus, evaluation epigenetic state can provide insights into adaptions occurring over course disease. Methods: We performed epigenome-wide association studies primary sclerosing cholangitis (PSC) biliary (PBC) using Illumina MethylationEPIC Bead Chip. Results: found evidence increased age...
Abstract Background: Many loci have been found to be associated with risk of epithelial ovarian cancer (EOC). However, although there is considerable variation in progression-free survival (PFS), no outcome at genome-wide levels significance. Methods: We carried out a association study (GWAS) PFS 2,352 women EOC who had undergone cytoreductive surgery and standard carboplatin/paclitaxel chemotherapy. Results: seven SNPs 12q24.33 (P < 5 × 10–8), the top SNP being rs10794418 (HR = 1.24;...
Abstract Background Benign breast disease (BBD) increases cancer (BC) risk progressively for women diagnosed with non-proliferative (NP) change, proliferative without atypia (PDWA), and atypical hyperplasia (AH). Leveraging data from 18,704 in the Mayo BBD Cohort (1967-2013), we evaluated temporal trends diagnoses how they have influenced associated BC over four decades. Methods were using standardized incidence ratios (SIRs) age-period-cohort modeling across eras—pre-mammogram (1967-1981),...