Chelsea A. Isom
A5021368974- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Viral-associated cancers and disorders
- Gastric Cancer Management and Outcomes
- Cancer Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Plant Disease Resistance and Genetics
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- Colorectal and Anal Carcinomas
- Pediatric Hepatobiliary Diseases and Treatments
- Multiple and Secondary Primary Cancers
- Parathyroid Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Phytase and its Applications
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Thyroid and Parathyroid Surgery
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Melanoma and MAPK Pathways
- Liver Diseases and Immunity
- Older Adults Driving Studies
- Genetic Associations and Epidemiology
Human Longevity (United States)
2024-2025
University of California, San Diego
2024-2025
Vanderbilt University Medical Center
2016-2021
University of Wisconsin–Madison
2019
Emory University
2017
Vanderbilt University
2016-2017
Stanford University
2017
The Ohio State University
2017
Washington University in St. Louis
2017
Boise State University
2008
To investigate the influence of type surgery (transplant vs resection) on overall survival (OS) in patients with hilar cholangiocarcinoma (H-CCA).Outcomes after resection for H-CCA are poor, yet transplantation is currently only reserved well-selected unresectable disease.All who underwent from 2000 to 2015 at 10 institutions were included. Three additionally had active transplant protocols similar selection criteria over time periods.Of 304 suspected H-CCA, 234 attempted and 70 enrolled a...
Pancreatic mucinous cystic neoplasms (MCNs) harbor malignant potential, and current guidelines recommend resection. However, data are limited on preoperative risk factors for malignancy (adenocarcinoma or high-grade dysplasia) occurring in the setting of an MCN.To examine resected MCNs to assess outcomes MCN-associated adenocarcinoma.Patients who underwent pancreatic resection at 8 academic centers Central Pancreas Consortium from January 1, 2000, through December 31, 2014, were...
<h3>Importance</h3> The current recommendation is to perform re-resection for select patients with incidentally discovered gallbladder cancer. optimal time interval both patient selection and long-term survival not known. <h3>Objective</h3> To assess the association of from initial cholecystectomy reoperation overall survival. <h3>Design, Setting, Participants</h3> This cohort study was conducted January 1, 2000, December 31, 2014 at 10 US academic institutions. A total 207 cancer who...
Most gallbladder cancers (GBCs) are discovered incidentally after routine cholecystectomy. The influence of timing diagnosis on disease stage, treatment, and prognosis is not known. Patients with GBC who underwent resection at 10 institutions from 2000 to 2015 were included. diagnosed (IGBC) nonincidentally (non-IGBC) compared. Primary outcome was overall survival (OS). Of 445 patients GBC, 266 (60%) IGBC 179 (40%) non-IGBC. Compared IGBC, non-IGBC more likely have R2 resections (43% vs 19%;...
Two important questions regarding the genetics of pancreatic adenocarcinoma (PDAC) are 1. Which germline genetic variants influence incidence this cancer; and 2. Whether PDAC causally predisposes to associated non-malignant phenotypes, such as type 2 diabetes (T2D) venous thromboembolism (VTE).
Curative-intent treatment for localized hilar cholangiocarcinoma (HC) requires surgical resection. However, the effect of adjuvant therapy (AT) on survival is unclear. We analyzed impact AT overall (OS) and recurrence free (RFS) in patients undergoing curative resection.We reviewed with resected HC between 2000 2015 from ten institutions participating U.S. Extrahepatic Biliary Malignancy Consortium. RFS OS. The probability OS were calculated method Kaplan Meier using multivariate Cox...
Background Although radical re‐resection for gallbladder cancer (GBC) has been advocated, the optimal extent of remains unknown. The current study aimed to assess impact common bile duct (CBD) resection on survival among patients undergoing surgery GBC. Methods Patients curative‐intent GBC were identified using a multi‐institutional cohort patients. Multivariable Cox‐proportional hazards regression was performed identify risk factors poor overall (OS). Results Among 449 identified, 26.9%...
BACKGROUND Current data on the utility of port‐site excision (PSE) during re‐resection for incidentally discovered gallbladder cancer (IGBC) in US are conflicting and limited to single‐institution series. METHODS All patients with IGBC who underwent curative at 10 institutions from 2000 2015 were included. Patients without PSE compared. Primary outcome was overall survival (OS). RESULTS Of 449 pts GBC, 266 discovered, which 193(73%) had data; 47 pts(24%) PSE, 146(76%) did not. The rate...
The objective of the current study was to define long-term survival patients with resectable hilar cholangiocarcinoma (HCCA) after preoperative percutaneous transhepatic biliary drainage (PTBD) versus endoscopic (EBD).Between 2000 and 2014, 240 who underwent curative-intent resection for HCCA were identified at 10 major hepatobiliary centers. Postoperative morbidity mortality, as well disease-specific (DSS) recurrence-free (RFS) analyzed among patients.The median decrease in total bilirubin...
The survival benefit of lymphadenectomy among patients with gallbladder cancer (GBC) remains poorly understood.Patients who underwent resection for GBC between 2000 and 2015 were identified from a US multi-institutional database. therapeutic index (LNM rate multiplied by 3-year overall [OS]) was determined to assess the lymphadenectomy.Among 449 patients, less than half had LNM (N = 183, 40.8%). median number evaluated metastatic lymph nodes (LNs) 3 (interquartile range [IQR]: 1-6) 1 (IQR:...