A5016664573- Toxin Mechanisms and Immunotoxins
- Catalytic Processes in Materials Science
- Catalysis and Oxidation Reactions
- Helicobacter pylori-related gastroenterology studies
- Catalysis and Hydrodesulfurization Studies
- Zeolite Catalysis and Synthesis
- CAR-T cell therapy research
- RNA modifications and cancer
- Transgenic Plants and Applications
- Cancer Immunotherapy and Biomarkers
- Ginseng Biological Effects and Applications
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Pancreatic function and diabetes
- PARP inhibition in cancer therapy
- Metabolism, Diabetes, and Cancer
- interferon and immune responses
- Traditional Chinese Medicine Analysis
- Liver Disease Diagnosis and Treatment
- Plant Virus Research Studies
- Immune cells in cancer
- melanin and skin pigmentation
- Diet, Metabolism, and Disease
- Catalysts for Methane Reforming
- Galectins and Cancer Biology
Yanbian University Hospital
2022-2025
Yanbian University of Science and Technology
2022-2025
Yanbian University
2019-2025
National Chung Hsing University
2025
Zhejiang Chinese Medical University
2024
Royal Society of Chemistry
2024
Centre National pour la Recherche Scientifique et Technique (CNRST)
2024
Jilin Medical University
2014-2023
Zhongnan Hospital of Wuhan University
2023
Wuhan University
2023
Gallic acid (3,4,5-trihydroxybenzoic acid, GA) is a phenolic compound found in many medicinal plants traditionally used China or patent medicine such as Feiyangchangweiyan capsule (FY capsule) for the treatment of gastrointestinal diseases decades. However, evidence gastroprotective effect GA deficient and pharmacological mechanisms remain limited. The present investigation was initiated to demonstrate understand potential underlying mechanism on ethanol-induced gastric ulcer rats. Gastric...
Abstract Background Betaine is a methyl donor and has been considered as lipotropic effect substance. But its mechanism remains unclear. Hepatic steatosis associated with abnormal expression of genes involved in hepatic lipid metabolism. DNA methylation contributes to the disregulation gene expression. Here we hypothesized that betaine supplement subsequent modifications alter are metabolism hence alleviate triglyceride accumulation. Methods Male wild-type (WT) C57BL/6 mice ( n = 6) were fed...
Glioblastoma (GBM) is the most common and malignant brain tumor in adults. Recently, programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) checkpoint blockades have been applied for GBM treatment. However, mechanism of PD-L1 upregulation still unclear. COP9 signalosome 6 (CSN6) crucial maintaining protein stabilization cancer cells. In this study, we human specimens cell lines to investigate whether EGFR-ERK pathway regulates CSN6 upregulation. Data from The Cancer Genome Atlas dataset...
Background Sarcopenia is prevalent in metabolic dysfunction-associated fatty liver diseases (MAFLD), and the primary treatment for both lifestyle modification. We studied how dietary components physical activity affect individuals with sarcopenia MAFLD. Materials methods conducted a study utilizing National Health Nutrition Examination Survey (NHANES) III (1988–1994) data Linked Mortality file (through 2019). The diagnosis of disease (FLD) was based on ultrasound images revealing moderate...
Abstract A growing number of publications have shown that resveratrol has anticancer effects and become a hotspot in cancer research. The purpose this study is to analyze the academic results research trends within field predict future field. We conducted literature search for from 2003 2022 using Science Citation Index Expanded Web Core Collection. visualization software was used perform bibliometric analysis. total 1463 were retrieved. China had highest publications. Taipei Medical...
This study aims to evaluate the gastro-protective effects of virgin coconut oil (VCO) on different ulcer models as compared standard drug (omeprazole).Three groups rats (6 per group for each model) were pre-treated with distilled water negative control group, 30 mg/kg omeprazole positive and VCO (2 ml rat) treatment group. Animals 7 days ulcers induced cold restraint stress, piroxicam, ethanol pylorus ligation. On day eight, animals sacrificed scores determined based macroscopic evaluation....
Melanoma stem cells (MSCs)-based vaccine strategies have been a potent immunotherapeutic approach for melanoma treatment, which aimed at inducing specific anti-tumor immunity and targeting cancer stem-like cells. As the main cancer-fighting immune cells, CD8+T play an important role in vaccine-induced antitumor immunity. Here, we developed novel MSC that induces to target specifically. The was prepared our study order determine effectiveness of proportion activity were examined spleen after...
Abstract Cisplatin (DDP) is a basic chemotherapy drug for gastric cancer (GC). With the increase of DDP concentration in clinical treatment, cells gradually became resistant. Therefore, it necessary to find effective therapeutic targets enhance sensitivity GC DDP. Studies have shown that Transmembrane protein 205 (TMEM205) overexpressed DDP-resistant human epidermoid carcinoma and correlates with resistance, database analyses show TMEM also GC, but its role cisplatin-resistant remains...
ABSTRACT This study investigates the synergistic inhibitory effects of combining stimulator interferon genes (STING) agonist cyclic diadenylate monophosphate (c‐di‐AMP) and ginsenoside RG3 on cisplatin (DDP)‐resistant gastric cancer (GC) cells. The objective is to identify novel therapeutic targets offers insights for clinical management DDP resistance. Various techniques were employed, including western blot, MTT assay, colony formation scratch transwell tubule flow cytometry, Hoechst 33342...
A practical and alternative approach to access thioesters is presented, utilizing readily available starting precursors such as carboxylic acids thiols via direct reductive C-S cross-coupling reactions under palladium catalysis. The present protocol features good atom economy, excellent yields, wide functional group tolerance, broad substrate scope, operational simplicity, mild reaction conditions with no additional steps.
Adriamycin (ADR) is a frequently employed chemotherapeutic agent for the management of breast cancer. Nevertheless, multidrug resistance (MDR) can impair its therapeutic efficacy in MDR characterized by increased expression P-glycoprotein (P-gp) efflux pump, up-regulation anti-apoptotic proteins, and downregulation pro-apoptotic proteins. Consequently, inhibition ATP-binding cassette (ABC) transporter proteins has been deemed most efficacious approach to overcome MDR. In this study, we used...