A5042640345- AI in cancer detection
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Medical Imaging and Pathology Studies
- Occupational and environmental lung diseases
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Lung Cancer Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Colorectal Cancer Screening and Detection
- Cancer Research and Treatments
- RNA modifications and cancer
- Renal and related cancers
- Chromatin Remodeling and Cancer
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Renal cell carcinoma treatment
- Molecular Biology Techniques and Applications
- Hepatitis C virus research
- Prostate Cancer Treatment and Research
- Pleural and Pulmonary Diseases
- Ovarian cancer diagnosis and treatment
- Glioma Diagnosis and Treatment
- Digital Imaging for Blood Diseases
Azienda Ospedaliera S.Maria
2024
Ospedale Cannizzaro
2019-2021
University of Turin
2008-2021
Ospedale Regina Margherita
2014
In colorectal cancer (CRC), artificial intelligence (AI) can alleviate the laborious task of characterization and reporting on resected biopsies, including polyps, numbers which are increasing as a result CRC population screening programs ongoing in many countries all around globe. Here, we present an approach to address two major challenges automated assessment histopathology whole-slide images. We AI-based method segment multiple ([Formula: see text]) tissue compartments H &E-stained...
Summary We investigated Toll-like receptors (TLR-3, -4 and -7) expression in circulating mononuclear cells of patients with immunoglobulin A nephropathy (IgAN), a disease debated relationships mucosal immunity. TLR-4 (detected by fluorescence activated cell sorter) mRNA transcriptional levels (Taqman) were significantly higher IgAN than healthy controls (P = 0·00200 P 0·0200). TLR-3 TLR-7 not modified significantly. In proteinuria was correlated 0·0312). group nephrotic syndromes, TLR-3, -7...
Inherited loss‐of‐function mutations in the BAP1 oncosuppressor gene are responsible for an inherited syndrome with predisposition to malignant mesothelioma (MM), uveal and keratinocytic melanoma, other malignancies. Germline that were autosomal dominant fashion identified nine families multiplex MM cases 25 multiple renal cell carcinoma, tumors. also sporadic cases, suggesting germline occur frequently. In this article, we report analysis of five 103 MM. One family carried a new truncating...
In the fully digital Caltagirone pathology laboratory, a reverse shift from to manual workflow occurred due server outage in September 2023. Here, insights gained this unplanned transition are explored. Surveying affected pathologists and technicians revealed unanimous preferences for time-saving error-reducing capabilities of methodology. Conversely, return methods highlighted increased dissatisfaction reduced efficiency, emphasising superiority workflows. This case study underscores that...
Somatic or germline mutations in up to 15 disease-causative genes are detectable 50% of patients with pheochromocytoma (PCC) and paraganglioma (PGL). Very recently, somatic H-RAS were identified by exome sequencing approximately 7% sporadic PCCs PGLs, association male sex benign behavior.To explore the prevalence RAS a cohort 271 PCC PGL from European registry compare genotype clinical pathological characteristics potential interest.Genetic screening for hotspot H-, N-, K-RAS was performed...
Introduction: To evaluate BRCA1-2 (breast cancer) detection in men with high risk PCa, including the oncological consequences for patient and family members. Materials Methods: From January 2023 to December 2024, 52 (median age 73 years;) confirmed PCa diagnosis underwent somatic germline BRCA1 BRCA2 assessment; 11/52 (21%) patients documented a history of cancer. Patients were at different clinical stages: high-grade (71% had Gleason score ≥ 8), locally advanced (54% cases) and/or...
Brugada syndrome is characterised by a typical ECG with ST segment elevation in the right precordial leads. Individuals this condition are susceptible to ventricular arrhythmias and sudden cardiac death. The principal gene responsible for SCN5A, which encodes α-subunit of Nav1.5 voltage-gated sodium channel. Mutations involving other genes have been increasingly reported, but their contribution has poorly investigated. Here we focused on SCN1B gene, β1-subunit channel its soluble β1b...
Identification and characterisation of monoclonal gammopathies renal significance (MGRS) is critical for therapeutic purposes. Amyloidosis represents one the most common forms MGRS, biopsy remains gold standard their classification, although mass spectrometry has shown greater sensitivity in this area.
The management of advanced stage non-small cell lung cancer is increasingly based on diagnostic and predictive analyses performed mostly limited amounts tumor tissue. evaluation Epidermal Growth Factor Receptor (EGFR) mutations have emerged as the strongest predictor response to EGFR-tyrosine kinase inhibitors mainly in patients with adenocarcinoma. Several EGFR mutation detection techniques are available, having both sensitivity specificity issues, being Sanger sequencing technique...