A5070913967- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Phagocytosis and Immune Regulation
- Insect and Arachnid Ecology and Behavior
- Mosquito-borne diseases and control
- CRISPR and Genetic Engineering
- Genetics, Aging, and Longevity in Model Organisms
- Sleep and Wakefulness Research
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- Dietary Effects on Health
- Light effects on plants
- Invertebrate Immune Response Mechanisms
Rockefeller University
2008-2023
Max Planck Institute for Infection Biology
2008
Mycobacterium tuberculosis is a facultative intracellular pathogen that inhibits phagosome maturation in macrophages thereby securing survival and growth. Mycobacteria reside an early endocytic compartment of near-neutral pH where they upregulate production complex glycolipids such as trehalose dimycolate. Here, we report dimycolate coated onto beads increased the bead retention phagosomes, i.e. at similar stage viable mycobacteria. Thus, single mycobacterial lipid sufficed to divert likely...
Sleep is vital for most animals, yet its mechanism and function remain unclear. We found that permeability of the BBB (blood–brain barrier)—the organ required maintenance homeostatic levels nutrients, ions, other molecules in brain—is modulated by sleep deprivation (SD) can cell-autonomously effect changes. observed increased known mutants as well acutely sleep-deprived animals. In addition to molecular tracers, SD–induced changes also penetration drugs used treatment brain pathologies....
Abstract Time-restricted feeding/eating (TRF/TRE) – limiting not the amount of food but daily time window intake is a dietary intervention that has been shown to improve health markers in model organisms and humans, whether these benefits translate into positive effects on aging longevity clear. We demonstrate here TRF robustly prolongs lifespan short-lived genetically tractable organism Drosophila melanogaster . Median extensions range between ∼10% ∼50% dependent sex, reproductive status,...
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