A5058968550- Neurobiology and Insect Physiology Research
- Circadian rhythm and melatonin
- Insect Utilization and Effects
- Sleep and Wakefulness Research
- Genetics, Aging, and Longevity in Model Organisms
- Insect and Arachnid Ecology and Behavior
- Sleep and related disorders
- Insect and Pesticide Research
- Obstructive Sleep Apnea Research
- Animal Behavior and Reproduction
University of Pennsylvania
2024
Rockefeller University
2021-2023
The University of Texas at Austin
2013
Sleep is vital for most animals, yet its mechanism and function remain unclear. We found that permeability of the BBB (blood–brain barrier)—the organ required maintenance homeostatic levels nutrients, ions, other molecules in brain—is modulated by sleep deprivation (SD) can cell-autonomously effect changes. observed increased known mutants as well acutely sleep-deprived animals. In addition to molecular tracers, SD–induced changes also penetration drugs used treatment brain pathologies....
Many organisms, including humans, have evolved dynamic social behaviors to promote survival. Public health studies show that isolation from groups is a major risk factor for adverse outcomes in but these lack mechanistic understanding. Animal models can provide insight into the molecular and neural mechanisms underlying how impacts through investigations using genetic, genomic, molecular, neuroscience methods. In this review, we discuss Drosophila melanogaster as robust genetic model...
Genome-wide profiling of rhythmic gene expression has offered new avenues for studying the contribution circadian clock to diverse biological processes. Sleep been considered one most important physiological processes that are regulated by clock, however, effects chronic sleep loss on remain poorly understood. In present study, we exploited Drosophila mutants insomniac1 (inc1 ) and wide awakeD2 (wakeD2 as models loss. We profiled transcriptomes head tissues collected from 4-week-old wild...
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Using Drosophila melanogaster larvae we asked whether distinct aversive stimuli have a common neuralrepresentation during associative learning. We tested the interchangeability of heat shock and electroshock punishments when used within single olfactory conditioning experiment. find that compared to animals trained with repetitive use punishment, two alternating results in similar Additionally, are shown different sensory origins. Therefore, while processed differently by melanogaster, value...