A5012073533- Anesthesia and Sedative Agents
- Ocular Diseases and Behçet’s Syndrome
- Cancer Cells and Metastasis
- Ocular Surface and Contact Lens
- Inflammatory mediators and NSAID effects
- ATP Synthase and ATPases Research
- Mesenchymal stem cell research
- Synthesis and properties of polymers
- Ocular Infections and Treatments
- Reproductive System and Pregnancy
- Cancer, Hypoxia, and Metabolism
- Inflammatory Bowel Disease
- Mitochondrial Function and Pathology
Center for Research in Molecular Medicine and Chronic Diseases
2021
Universidade de Santiago de Compostela
2021
Metabolic reprogramming is considered hallmarks of cancer. Aerobic glycolysis in tumors cells has been well-known for almost a century, but specific factors that regulate lactate generation and the effects both cancer stroma are not yet well understood. In present study using breast cell lines, human primary cultures tumors, immune deficient murine models, we demonstrate POU1F1 transcription factor functionally clinically related to metabolic fibroblasts activation. Mechanistically,...
Inflammatory bowel disease (IBD), including Crohn’s (CD) and ulcerative colitis (UC), is increasingly prevalent current therapies are not completely effective. Mesenchymal stem cells emerging as a promising therapeutic option. Here, the effect of local hydrogel application loaded with conditioned medium (CM) from human uterine cervical (hUCESC-CM) in an experimental acute mice model has been evaluated. Colitis induction was carried out C57BL/6 by dissolving dextran sulfate sodium (DSS)...
Breast cancer stem cells (BCSCs) have been proposed as the cause of resistance to conventional treatments and origin breast recurrence metastasis. However, BCSC is not fully understood. Using cell lines with POU1F1 overexpression knockdown well immunodeficient mice models, this study provides compelling evidence role in reprogramming into BCSC-like by deregulating CD24, CD44, CD133, ALDH markers. In addition, a subpopulation from overexpressing MCF-7 high levels present functional changes,...
Uveitis is an infrequent disease which constitutes a major cause of ocular morbidity. Correct management essential, being corticosteroids its cornerstone. In case contraindication to or treatment failure, the use topical tacrolimus (TAC) could be alternative has already demonstrated safety and effectiveness in other pathologies. However, TAC eye drops are not marketed, thus their elaboration must carried out Hospital Pharmacy Departments (HPDs).32 Sprague-Dawley rats were divided into 4...