A5022516734- TGF-β signaling in diseases
- Cancer Cells and Metastasis
- Dialysis and Renal Disease Management
- Growth Hormone and Insulin-like Growth Factors
- Protease and Inhibitor Mechanisms
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Bone and Dental Protein Studies
- Chronic Kidney Disease and Diabetes
- Healthcare cost, quality, practices
- Central Venous Catheters and Hemodialysis
- Renal Diseases and Glomerulopathies
- Breast Lesions and Carcinomas
- Immune cells in cancer
- Vascular anomalies and interventions
- Diabetes Treatment and Management
- Renin-Angiotensin System Studies
- Cancer and Skin Lesions
- Hedgehog Signaling Pathway Studies
- Metabolism, Diabetes, and Cancer
- Immunotherapy and Immune Responses
- Organ Donation and Transplantation
- Estrogen and related hormone effects
- Protein Tyrosine Phosphatases
Hospital Universitario de Canarias
1997-2024
Universidade de Santiago de Compostela
1989-2022
Universidad Autónoma de Madrid
1999-2015
Universidad de La Laguna
1997
Metabolic reprogramming is considered hallmarks of cancer. Aerobic glycolysis in tumors cells has been well-known for almost a century, but specific factors that regulate lactate generation and the effects both cancer stroma are not yet well understood. In present study using breast cell lines, human primary cultures tumors, immune deficient murine models, we demonstrate POU1F1 transcription factor functionally clinically related to metabolic fibroblasts activation. Mechanistically,...
The Pit-1 transcription factor (also know as POU1F1) plays a critical role in cell differentiation during organogenesis of the anterior pituitary mammals and is transcriptional activator for gene transcription. Increased expression has been reported human tumorigenic breast cells. Here, we found that overexpression or knockdown cancer lines induced profound phenotypic changes proteins involved proliferation, apoptosis, invasion. Some these protumorigenic effects were mediated by upregulation...
Abstract Cancer progression requires cells surrounding tumors be reeducated and activated to support tumor growth. Oncogenic signals from malignant directly influence stromal composition activation, but the factors mediating this communication are still not well understood. We have previously shown that transcription factor POU class 1 homeobox (POU1F1), also known as Pit‐1, induces profound changes on neoplastic cell‐autonomous processes favoring metastasis in human breast cancer. Here we...
The transcription factor Pit-1/Pou1f1 regulates GH and prolactin (PRL) secretion in the pituitary gland. Pit-1 expression regulation by have also been demonstrated mammary However, no data are available on role of breast PRL. To evaluate this role, several human cancer cell lines were transfected with either vector or a small interference RNA construct, followed PRL mRNA protein evaluation. In addition, transient transfection MCF-7 cells reporter construct containing proximal promoter, ChIP...
Abstract Introduction The POU class 1 homeobox transcription factor (POU1F1, also known as Pit-1) is expressed in the mammary gland and its overexpression induces profound phenotypic changes proteins involved cell proliferation, apoptosis, invasion. Patients with breast cancer elevated expression of Pit-1 show a positive correlation occurrence distant metastasis. In this study we evaluate relationship between two collagenases: matrix metalloproteinase-1 (MMP-1) metalloproteinase-13 (MMP-13),...
// Samuel Seoane 1, 2 , Efigenia Arias 2, 3 Rita Sigueiro 4 Juan Sendon-Lago Anxo Martinez-Ordoñez Esteban Castelao 5 Noemí Eiró 6 Tomás Garcia-Caballero 7 Manuel Macia Rafael Lopez-Lopez 8 Miguel Maestro Francisco Vizoso Antonio Mouriño Roman Perez-Fernandez 1 Department of Physiology, University Santiago de Compostela, Compostela 15782, Spain Center for Research in Molecular Medicine and Chronic Diseases-CIMUS, Obstetrics Gynecology, Organic Chemistry, Laboratory Ignacio Rivas, Oncology...
Ovarian cancer is the most lethal of all gynecological cancers, despite advances in surgical techniques and medical treatments. During last years, therapies based on mesenchymal stem cells particularly their secretome (conditioned medium, CM) have emerged as promising treatments for various types tumors.In present study, we evaluated vivo antitumor effect human uterine cervical cell conditioned medium (hUCESC-CM) after intraperitoneal administration an ovarian mouse model.We found that...
Abstract Background and Aims Assisted peritoneal dialysis (APD), whether partial or total, is a home-based technique for patients who have lost their independence due to age comorbidities, requiring some assistance manage treatment. It also viable option ineligible Peritoneal Dialysis (PD) social, cognitive, physical barriers those approaching the end of life. Moreover, APD has demonstrated lower hospitalization mortality rates, costs, similar quality life compared in center Hemodialysis...