A5103019310- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Genital Health and Disease
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Colorectal and Anal Carcinomas
- Sarcoma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Molecular Biology Techniques and Applications
- Peroxisome Proliferator-Activated Receptors
- Cancer Risks and Factors
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- Lymphoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- interferon and immune responses
Beijing Obstetrics and Gynecology Hospital
2016-2025
Capital Medical University
2016-2025
Jiangsu University
2025
Affiliated Hospital of Jiangsu University
2025
Shanghai Ninth People's Hospital
2023-2025
Shanghai Jiao Tong University
2023-2025
Stomatology Hospital
2025
Chengdu University of Traditional Chinese Medicine
2024
Sichuan Provincial Hospital of Traditional Chinese Medicine
2024
Tsinghua University
2024
Tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) widely participate malignant progression cancer. Previously, we have demonstrated that M1-like TAMs cascaded a stem-like phenotype of oral squamous cell carcinoma (OSCC). Yet, underlying mechanisms still need to be for regulation on cancer stem cells (CSCs) OSCC. In this study, investigated group CSCs with increased expression cluster differentiation 10 (CD10), which acted as mediator interaction network between and...
// Sansan Chen 1, 2, * , Xinglu Gui’e Xie 3, Yue He 2 Daoyu Yan Dianpeng Zheng Shi Li 1 Xinyang Fu Yeping Xiang Pang Zhiming Hu Hongwei Wanlong Tan Jinlong Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China Institute Biotherapy, School Biotechnology, 3 KingMed Laboratory Medicine, Guangzhou These authors contributed equally to this work Correspondence to: Li, email: lijinlong@smu.edu.cn Tan, tanwanlong@gmail.com hongwei1@yahoo.com...
Denosumab is authorized to treat several diseases, including cancer and bone disorders. Nevertheless, its use in clinical practice has been affected by safety concerns. The work retrospectively investigated adverse events (AEs) of denosumab better understand toxicities.
Background and purpose The large vessel occlusion (LVO) in middle cerebral artery (MCA) trunk (i.e., M1 segment) caused by intracranial atherosclerotic disease (ICAD) could introduce with different infarct patterns. We aimed to compare the clinical outcomes among these patterns investigate associations between morphological parameters of contralateral MCA (cMCA) segment Methods Patients stroke attributed M1-ICAD-LVO were enrolled. categorized into artery-artery embolism (AAE), infarct,...
Objective To evaluate the mechanism of Kielin/chordin-like protein ( KCP ) in resistance cervical cancer cells to paclitaxel. Method A squamous carcinoma cell line (SiHa) with knockout was constructed and treated Key functions were assessed by colony formation assay, measurement proliferation 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) FACS-based detection apoptosis. The downstream -mediated paclitaxel then examined using human gene chip IPA bioinformatics analysis,...
BACKGROUND The aim of this study was to explore the potential role TRPC6 in pathophysiology HK-2 cell injury following ischemia reperfusion (I/R). MATERIAL AND METHODS expression analyzed by immunofluorescence staining. siRNA transfected knockout cells, and vitro I/R then induced. Cell apoptosis necrosis were determined Annexin V-FITC/PI Necroptosis necrostatin-1 expressions necroptosis-related proteins evaluated. OAG, SKF96365, or KN-93 further used interfere with expression. RESULTS...
Paclitaxel (PTX) is an antimitotic drug that possesses potent anticancer activity, but its therapeutic potential in the clinic has been hindered by resistance. Here, we report a mechanism which cancer cells can exit from PTX-induced mitotic arrest, i.e. slippage, and avoid subsequent death resulting In experiencing Cdc6 protein level was significantly upregulated, Cdk1 activity inhibited, Cohesin/Rad21 cleaved as result. depletion RNAi or Norcantharidin inhibited up-regulation, maintained...
The purpose of this prospective cohort study is to evaluate the importance screening and its diagnostic accuracy compared with pathological diagnosis cervical intraepithelial neoplasia (CIN) vaginal (VAIN). enrolled 419 patients (pts) was conducted between February 1, 2015 January 31, 2016 at Beijing Obstetrics Gynecology Hospital, Capital Medical University. All pts underwent multipoint biopsy cervix wall directed by colposcopy. samples examination. Among them, 201 (48.0%) were diagnosed...
Clinical non‑functioning pituitary adenoma (NFPA) accounts for >30% of all adenomas, and the recurrence rate is notably high. The ability to predict tumour during initial surgery will aid in determining if adjunctive therapy required reduce recurrence. With aim developing a circular RNA (circRNA) signature improve prognosis prediction NFPA, present study examined circRNA expression profiles 73 patients with NFPA from Beijing Tiantan Hospital using high‑throughput chip technology. dataset was...
To reveal the potential pathogenesis of ischemia/reperfusion (I/R) injury.GSE9943 were downloaded from Genome Expression Omnibus database, including I/R and control samples for both Brown Norway (BN) Sprague Dawley (SD) rats (3 rats/each group). Then differentially expressed genes (DEGs) identified by limma package. miRNA-target gene network pairs predicted using WebGestalt, protein-protein interactions (PPI) based on STRING followed networks construction Cytoscape. Next, ClusterONE was used...
Abstract This study compared the efficacy of neoadjuvant chemotherapy (NACT) followed by radical surgery (RS) vs primary surgical treatment (PST) in patients diagnosed with International Federation Gynecology and Obstetrics (FIGO) stage IB2/IIA2 cervical cancer. Data 303 cancer who received therapy for at 7 medical centers Beijing, China between January 1, 2009 December 31, 2016 through 2017 were collected retrospectively. The response rates, characteristics, overall survival (OS) durations...
To investigate the mechanism by which apolipoprotein A1 (APOA1) enhances resistance of cervical squamous carcinoma to platinum-based chemotherapy.Two cell lines (SiHa and Caski) overexpressing APOA1 were constructed, treated with carboplatin, compared normal control cells.In both SiHa Caski lines, clone-forming ability CBP-treated cells was lower than that untreated cells, change in number clones (p < 0.05), indicating overexpression enhanced chemoresistance. A screen for downstream proteins...
Abstract Background Radiosensitivity is limited in cervical cancer (CC) patients due to acquired radiation resistance. In our previous studies, we found that immediate-early response 5 (IER5) upregulated CC cells upon exposure and decreases cell survival by promoting apoptosis. The details on the transcriptional regulation of radiation-induced IER5 expression are unknown. Studies recent years have suggested Pol II-associated factor 1 (PAF1) a pivotal transcription for certain genes “induced”...
To define the role of immediate-early 5 (IER5) gene as a promising biomarker in predicting radiosensitivity and prognosis cervical cancer patients receiving cisplatin-based concurrent chemoradiotherapy (DDP-CCRT).Our investigations found that IER5 level was markedly elevated after being treated with irradiation, which indicated closely dose induced. By contrast, correlation between cannot be confirmed by present study. The up-regulation expression effectively increased cell apoptosis...
The phosphatidylinositol 3 kinase (PI3K)/protein B (AKT) signaling pathway is considered important for cell survival and has been shown to mediate various anti-apoptotic biological effects. This study explored the role of Toll-like receptor 4 (TLR4)-mediated PI3K/AKT-glycogen syn-thase 3β (GSK-3β) pathways in lipopolysaccharide-induced apoptosis a primary culture hippocampal neurons. Results demonstrated that apoptotic ratio neurons stimulated by lipopolysaccharide was significantly higher...
The purpose of this study is to investigate short-term efficacy as defined by the Response Evaluation Criteria in Solid Tumors (RECIST) and pathological response neoadjuvant chemotherapy (NACT) comprised paclitaxel cisplatin (TP) followed radical surgery patients with locally advanced cervical cancer (LACC).This a prospective involving 61 women histologically confirmed LACC referred for NACT following at Beijing Obstetrics Gynecology Hospital between April 2013 January 2015.The was evaluated...