A5072952680- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Botulinum Toxin and Related Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Sleep and Wakefulness Research
- Cerebral Palsy and Movement Disorders
- Neurology and Historical Studies
- Genetic Neurodegenerative Diseases
- Advanced Neuroimaging Techniques and Applications
- Balance, Gait, and Falls Prevention
- Autism Spectrum Disorder Research
- Mental Health and Psychiatry
- Olfactory and Sensory Function Studies
- Voice and Speech Disorders
- Medical Case Reports and Studies
- Mitochondrial Function and Pathology
- Health disparities and outcomes
- Health Systems, Economic Evaluations, Quality of Life
University of Michigan
2017-2025
A. Alfred Taubman Health Care Center
2017-2024
VA Ann Arbor Healthcare System
2023
Geriatric Research Education and Clinical Center
2023
Michigan United
2023
John Wiley & Sons (United States)
2018
Abstract Digital health technologies can provide continuous monitoring and objective, real-world measures of Parkinson’s disease (PD), but have primarily been evaluated in small, single-site studies. In this 12-month, multicenter observational study, we whether a smartwatch smartphone application could measure features early PD. 82 individuals with early, untreated PD 50 age-matched controls wore research-grade sensors, smartwatch, while performing standardized assessments the clinic. At...
Digital measures may provide objective, sensitive, real-world of disease progression in Parkinson's (PD). However, multicenter longitudinal assessments such are few. We recently demonstrated that baseline gait, tremor, finger tapping, and speech from a commercially available smartwatch, smartphone, research-grade wearable sensors differed significantly between 82 individuals with early, untreated PD 50 age-matched controls. Here, we evaluated the change these over 12 months observational...
Abstract Subthalamic nucleus (STN) deep brain stimulation (DBS) is well-established for improving appendicular motor signs but its effect on axial less clear. Additionally, the location of active electrode contact within STN has been shown to differentially affect outcomes. We investigate DBS and role Axial scores were assessed in 70 patients with advanced PD between 6 12 months after bilateral DBS. Repeated measures one-way ANOVA was performed compare mean different medication treatment...
Introduction Inconsistent effects of subthalamic deep brain stimulation (STN DBS) on pain, a common non-motor symptom Parkinson's disease (PD), may be due to variations in active contact location relative some pain-reducing locus stimulation. This study models and compares the loci maximal effect for pain reduction motor improvement STN DBS. Methods We measured Movement Disorder Society Unified PD Rating Scale (MDS-UPDRS) Part I score (item-9), MDS-UPDRS III score, preoperatively 6–12 months...
<h3>Background and Objectives</h3> Chronic health conditions are influenced by social determinants of (SDH) including neighborhood-linked markers affluence. We explored whether neighborhood socioeconomic factors differ in people with different types clinical movement disorders (MDs). <h3>Methods</h3> conducted a retrospective study patients seen MD clinics at our center 2021. Patient data were linked to the US National Neighborhood Data Archive census tract data. evaluated variations across...
OBJECTIVE The effect of subthalamic nucleus (STN) deep brain stimulation (DBS) on urinary dysfunction and constipation in Parkinson’s disease (PD) is variable. This study aimed to identify potential surgical nonsurgical variables predictive these outcomes. METHODS authors used the Movement Disorder Society–Unified Disease Rating Scale (MDS-UPDRS) Part I assess (item 10) 11) preoperatively at 6–12 months postoperatively. A multiple linear regression model was investigate impact global...
We know little about how well the goals and results of clinical trials in Parkinson disease (PD) reflect priorities patients broader PD community.We conducted a review registered on http://clincialtrials.gov from 2007 to 2016 explore whether have moved closer therapeutic priority articulated by community.Using search terms: Parkinson, interventional trials, phase "0-4," we categorized studies http://clinicaltrials.gov between January 1, December 31, 2016. Seven hundred sixty-six met criteria...
ABSTRACT Introduction The effect of subthalamic nucleus deep brain stimulation (STN DBS) on urinary dysfunction and constipation in Parkinson’s disease (PD) is variable. This study aims to identify potential surgical non-surgical variables predicting their outcome. Methods We used the Movement Disorder Society-Unified PD Rating Scale (MDS-UPDRS) Part I assess (item 10) 11) preoperatively 6-12 months postoperatively. A multiple linear regression model was investigate impact Global Cerebral...
ABSTRACT Introduction Inconsistent effects of subthalamic deep brain stimulation (STN DBS) on pain, a common non-motor symptom Parkinson’s disease (PD), may be due to variations in active contact location relative pain-reducing locus stimulation. Objective To distinguish the loci maximal effect for pain and motor improvement STN region. Methods We measured Movement Disorder Society Unified PD Rating Scale (MDS-UPDRS) Part I score (item-9), MDS-UPDRS III score, preoperatively 6-12 months...
Identifying individuals with isolated rapid eye movement sleep behavioral disorder (iRBD) is an important clinical research priority for future synucleinopathy trials. Nevertheless, little known about the breadth of settings where diagnoses iRBD are initially made.