A5055266038- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Gastric Cancer Management and Outcomes
- Nutrition and Health in Aging
- Esophageal Cancer Research and Treatment
- Geriatric Care and Nursing Homes
- Geographic Information Systems Studies
- Lung Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- Intensive Care Unit Cognitive Disorders
- Radiomics and Machine Learning in Medical Imaging
- Trauma Management and Diagnosis
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Urban Green Space and Health
- Hip and Femur Fractures
- Cardiac, Anesthesia and Surgical Outcomes
- Health and Wellbeing Research
- Neuroscience and Music Perception
- Health and Medical Research Impacts
- Trauma and Emergency Care Studies
- Long-Term Effects of COVID-19
- Delphi Technique in Research
- Cardiac Arrest and Resuscitation
University of Leeds
2014-2024
Bradford Teaching Hospitals NHS Foundation Trust
2019-2024
Bradford Royal Infirmary
2019
St James's University Hospital
2015
Abstract Introduction Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty unclear. Methods This multi-centre cohort study involved patients aged 18 years and hospitalised COVID-19, using routinely collected data. We used Cox regression analysis to assess impact age, delirium on risk inpatient mortality, adjusting for sex, illness severity, inflammation co-morbidities. ordinal logistic Clinical Frailty Scale (CFS)...
<h3>ABSTRACT</h3> Frailty is a common condition in later life which minor stressors may result major changes health. While the biological mechanisms of frailty are increasingly understood, relationships with wider determinants health, health inequalities and concept resilience less well-established role clinician their modification well understood. The modifiable conditions people born, grow, work live, set systems shaping daily life. They interact across course, driving well-recognised...
National guidelines recommend trastuzumab for treatment of patients with metastatic HER2-positive gastric cancer (GC). There is currently no guideline indicating the number biopsy specimens and location from which they should be obtained to reliably determine human epidermal growth factor receptor 2 (HER2) status in GC. The aim this pilot study was (a) quantify tumor cells different regions assess spatial heterogeneity HER2 expression (b) establish required within achieve concordance between...
// Matthew D. Hale 1 , Nankivell 2 Gordon G. Hutchins 1, 3 Sally P. Stenning Ruth E. Langley Wolfram Mueller 4 Nicholas West Alexander I. Wright Darren Treanor Lindsay C. Hewitt 7 William H. Allum 5 David Cunningham Jeremy Hayden 6 Heike Grabsch Pathology and Tumour Biology, Leeds Institute of Cancer Pathology, University Leeds, UK Medical Research Council Clinical Trials Unit at College London, Department Histopathology, St James's Oncology, Teaching Hospitals NHS Trust, Gemeinschaftspraxis...
Abstract Background There is lack of standardisation in assessment tools used geriatric medicine research, which makes pooling data and cross-study comparisons difficult. Methods We conducted a modified Delphi process to establish measures be included within core extended datasets for research the United Kingdom (UK). This three complete questionnaire rounds, one consensus meeting. Participants were selected from attendance at NIHR Newcastle Biomedical Research Centre meeting, May 2019,...
Abstract Background self-reported data regarding health conditions are utilised in both clinical practice and research, but their agreement with general records is variable. The extent of this variability poorly studied amongst older adults, particularly those multiple conditions, cognitive impairment or frailty. This study investigates the between practice-recorded such patients impact participant factors on agreement. Methods was collected from participants Community Ageing Research 75+...
Background: Frailty is a common condition in older people affecting around 1.8 million the UK and independently associated with adverse outcomes. commonly measured Clinical Scale (CFS) which involves face to assessment. There evidence CFS can be assigned retrospectively from information patient records, but no research has assessed whether scores using routine inpatient records. We aimed assess could accurately hospital records setting. Methods: Forty newly admitted patients aged 65 over...
Growing research in geriatric medicine is a priority area. Currently, involvement of geriatricians lags behind other specialties. The reasons for this are multifactorial, but lack training infrastructure within higher specialist contributory. This widespread across European countries and internationally. Geriatric Medicine Research Collaborative (GeMRC) offers an opportunity to engage trainees research, regardless their previous individual experiences. Utilising national trainee networks,...
49 Background: Neoadjuvant chemotherapy (chemo) followed by surgery is the standard treatment for UK patients with resectable oesophageal cancer [OeC] since OE02 trial (Allum et al. J. Clin. Oncol, 2009), yet some receive no benefit from chemo. We investigated whether tumour cell density (TCD) in pre-chemo biopsy can predict patient chemo among patients. Methods: Hematoxylin and eosin stained diagnostic slides 281 OeC reflective of whole population based on characteristics survival (70%...
Summary Despite the use of multimodal treatment, survival esophageal cancer (EC) patients remains poor. One proposed explanation for relatively poor response to cytotoxic chemotherapy is intratumor heterogeneity. The aim was establish a statistical model objectively measure heterogeneity proportion tumor (IHPoT) and this newly developed method IHPoT in pretreatment biopsies from EC recruited OE02 trial. A mixed effect (MEM) established estimating based on variation hematoxylin/eosin (HE)...
Abstract Gastric cancer (GC) is the third leading cause of cancer-related death worldwide. With advent immunotherapies, there a need to characterize phenotype tumor infiltrating immune cells and co-localized cells. We have shown previously that high density CD45R0+ T related better prognosis in Japanese GC. However, variation T-cell infiltration GC still not understood. hypothesized an increased CD8+ activation (high cell Ki67 proliferation index). Purpose: To establish frequency...