Non-alcoholic fatty liver disease (NAFLD), one of the most common diseases, is caused by disruption hepatic lipid homeostasis. It associated with insulin resistance as seen in type 2 diabetes mellitus. Glucagon-like peptide-1 (GLP-1) an incretin that increases sensitivity and aids glucose metabolism. In recent vivo vitro studies, GLP-1 presents a novel therapeutic approach against NAFLD increasing acid oxidation, decreasing lipogenesis, improving this report, we provide overview role...

Abstract This study aimed to clarify how masticatory muscle atrophy induced by botulinum toxin (BTX) injection affects cortical bone quality of the mandible using 3D modeling technology. A total 39 young (26.9 ± 6.0 years) and 38 post-menopausal (55.3 6.3 females were included. Computed tomography (CT) images obtained before after 12 months treatment. Predictor variables application a stabilization splint, and/or two times BTX in bilateral temporalis masseter muscles within six-month...

Abstract Oral health condition, bone mineral density, skeletal muscle mass, fall, fracture, and frailty seem to be strongly interconnected. This study aimed investigate associations between probability of osteoporotic fractures oral in the elderly. In total, 2322 Korean subjects from 2008—2009 Korea National Health Nutritional Examination Survey aged over 65 years were included. The 10-year probabilities major hip calculated using Fracture Risk Assessment (FRAX) tool. Data on anthropometry,...

Objectives: This study aimed to evaluate the quality and readability of web pages providing information about hand osteoarthritis using several authorized methods.Methods: A page exploration was performed Google internet search engine. The three terms, "hand osteoarthritis," "finger OA," were used top 100 ranked websites selected divided into six categories. Health on Net Foundation (HON) grade scale, an instrument for judging written consumer health treatment choice (DISCERN instrument),...

Objectives To explore the role of autonomic dysregulation in otologic symptoms among individuals with temporomandibular disorders (TMDs).

Treatments for distal radius fractures (DRFs) are determined by various factors. Therefore, quantitative or qualitative tools have been introduced to assist in deciding the treatment approach. This study aimed develop a machine learning (ML) model that determines need surgical patients with DRFs using ML incorporates clinical data concatenated plain radiographs anteroposterior and lateral views. Radiographic from 1,139 were collected used train models. To analyze integrate effectively,...

This study aims to clarify the potential role of growth differentiation factor-15 (GDF-15) as a myokine in bone metabolism and muscle function females with osteoporosis. In total, 45 female participants (71.0 ± 8.5 years) distal radius fractures were recruited. Participants classified healthy/osteopenic (n = 28) (CON) or osteoporotic 17) (OP) according their T-score from areal mineral density (aBMD) femoral neck. Body mass index, upper arm calf circumferences, handgrip strength assessed....

Selenoprotein P (SEPP1) and fetuin-A, both circulating liver-derived glycoproteins, are novel biomarkers for insulin resistance nonalcoholic fatty liver disease. However, the effect of exendin-4 (Ex-4), a glucagon-like peptide-1 receptor agonist, on expression hepatokines, SEPP1, is unknown. The human hepatoma cell line HepG2 was treated with palmitic acid (PA; 0.4 mM) tunicamycin (tuni; 2ug/ml) or without (100 nM) 24 hours. change in PA-induced endoplasmic reticulum (ER) stress markers by...

S-adenosyl methionine (SAM) is a key intermediate in the metabolism of sulfur amino acids and major methyl donor cell. Although low plasma level SAM has been associated with atherosclerosis, effect administration on atherosclerosis not known. Endothelial dysfunction an early prerequisite for atherosclerosis. This study was undertaken to investigate possible preventive endothelial molecular mechanism its action. treatment prevented high fat diet (HFD)-fed rats. In cultured human aortic cells,...

Background:The Quick Disabilities of the Arm, Shoulder, and Hand questionnaire (QuickDASH) is one most widely used questionnaires for assessing functional ability patients with upper extremity diseases.Carpal tunnel syndrome (CTS) common neuropathic disease in extremities.The aim this study was to verify validity, reliability, responsiveness Korean version QuickDASH (K-QuickDASH) CTS.Methods: In total, 83 subjects who underwent open carpal release (CTR) operation were selected.They fulfilled...

Background: The aim of this study was to determine when primary metacarpal corrective osteotomy is recommended in patients with Flatt type IV radial polydactyly. Methods: A total 78 polydactyly were included. authors performed if the angulation metacarpophalangeal joint not correctable by intraoperative stress test. measured deviation angle thumb simple posteroanterior radiographs. clinical outcomes assessed using Japanese Society for Surgery Hand evaluation score and correction angle. These...

The aims of this study were to propose a novel implant design for the proximal interphalangeal joint (PIPJ) hand using rolling contact (RCJ) mechanism and derive an optimal based on human PIPJ kinematics.In total, 10 participants with normal PIPJs enrolled in study. True lateral finger radiographs obtained 10° increments from 0º (full extension) 120° flexion PIPJ. Radiographs used determine average center rotation, which formed basis mathematical expression kinematics. variations extensor...

Background: Women with cosmetic breast implants have significantly lower rates of subsequent cancer than the general population (relative risk, 0.63; 95 percent CI, 0.56 to 0.71). The authors hypothesize that implant-induced local inflammation stimulates immunosurveillance recognition tumor antigen. Methods: Sera were collected from two cohorts healthy women: women long-term (i.e., for >6 months) and implant-naive women. Antibody responses antigens tested by enzyme-linked immunosorbent...

Abstract Background Masticatory ability is an essential factor for sustaining quality of life and social systemic well-being, particularly in elderly. This study aimed to reveal the association between subjective masticatory difficulty skeletal bone mineral density (BMD). Methods Data from Korean National Health Nutrition Examination Survey, which was conducted 2008 2011 were analyzed. included 13,092 Koreans (5656 males, 7436 females) over 50 years age. evaluated based on a self-reported...

Objectives Mechanical and biochemical bone properties are influenced by muscles. However, the muscle-bone interaction has not been fully elucidated regarding upper extremities. The objective of present study was to evaluate mechanical at forearm evaluating relationship between three-dimensional (3D) cortical models derived from conventional computed tomography (CT) images handgrip strength (HGS). Methods A total 108 women (mean age, 75.2 ± 9.4 years; range, 62–101 years) with a distal radius...

A total of 154 patients with De Quervain tendinopathy were randomized into a blind injection group or an ultrasound-guided to compare effectiveness and complications steroid injection. The visual analogue scale score for pain, Finkelstein test result, Disability the Arm, Shoulder, Hand (DASH) assessed at 12 24 weeks follow-up. At weeks, DASH scores significantly better in group, but mean difference was less than minimum clinically important difference. There no between groups weeks. pain not...

The occurrence of osteoarthritis (OA) the temporomandibular joint (TMJ) in juveniles could be associated with fluctuating levels oestrogen and growth hormone (GH) during adolescence.To investigate extent skeletal maturation predicted adult height adolescents TMJ OA.In total, 155 (54 males, 101 females; mean age, 14.1 ± 2.0 years) were enrolled. Among them, 19 (CON) showed no sign TMD, 50 exhibited signs disc displacement but did not have OA (TMDnoOA), 23 initial stage (TMJOAini) 63 severe...