A5100781651- Molecular Biology Techniques and Applications
- Protease and Inhibitor Mechanisms
- Forensic and Genetic Research
- Congenital limb and hand anomalies
- Nuclear Receptors and Signaling
- Galectins and Cancer Biology
- Bacillus and Francisella bacterial research
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Dupuytren's Contracture and Treatments
- Pharmacological Effects of Natural Compounds
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Bacteriophages and microbial interactions
- Hops Chemistry and Applications
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- Metabolomics and Mass Spectrometry Studies
- Cancer-related Molecular Pathways
- Veterinary medicine and infectious diseases
- Muscle Physiology and Disorders
- Identification and Quantification in Food
National Forensic Institute
2019-2022
Kangbuk Samsung Hospital
2020
National University College
2020
New Generation University College
2020
Seoul National University Hospital
2020
Sungkyunkwan University
2020
Boramae Medical Center
2020
Gachon University Gil Medical Center
2020
Incheon Medical Center
2020
Eulji University
2020
Abstract Background: Mitochondria are the main sites for fatty acid oxidation and play a central role in lipotoxicity nonalcoholic steatohepatitis. Aims: We investigated whether carnitine prevents free ( FFA )‐induced vitro vivo . Methods: HepG2 cells were incubated with , along complexes. Mitochondrial β‐oxidation, transmembrane potential, intracellular ATP levels changes mitochondrial copy number morphology analysed. Otsuka Long‐Evans Tokushima Fatty rats segregated into three experimental...
H. pylori is classified as a group I carcinogen by WHO because of its involvement in gastric cancer development. Several reports have suggested anti-bacterial effects menadione, although the effect menadione on major virulence factors and pylori-induced inflammation yet to be elucidated. In this study, therefore, we demonstrated that has anti-H. anti-inflammatory effects. Menadione inhibited growth reference strains clinical isolates. reduced expression vacA pylori, translocation VacA...
Abstract Background: Interindividual genetic differences in susceptibility to chemical carcinogens are among the most important host factors human cancer. The present study was undertaken reveal association between polymorphism of CYP2E1 (CYP2E1/ Pst I and CYP2E1/ Dra I) with gastric cancer development Koreans. Methods: In study, 120 patients 145 controls no history tumors were analyzed. determined by polymerase chain reaction‐restriction fragment length polymorphisms (PCR‐RFLP), or PCR...
Background: The aim of this study was to determine when primary metacarpal corrective osteotomy is recommended in patients with Flatt type IV radial polydactyly. Methods: A total 78 polydactyly were included. authors performed if the angulation metacarpophalangeal joint not correctable by intraoperative stress test. measured deviation angle thumb simple posteroanterior radiographs. clinical outcomes assessed using Japanese Society for Surgery Hand evaluation score and correction angle. These...
NAD(P)H:Quinone Oxidoreductase 1 (NQO1) C609T missense variant (NQO1*2) and 29 basepair (bp)-insertion/deletion (I29/D) polymorphism of the NRH:Quinone 2 (NQO2) gene promoter have been proposed as predictive prognostic factors for cancer development progression. The purpose this study is to investigate relationship between NQO1/NQO2 genotype clinico-pathological features papillary thyroid microcarcinoma (PTMC). Genomic DNA was isolated from 243 patients; clinical data were retrospectively...
We studied the effects of extract aerial parts hydroponically cultured ginseng (HGE) on alcohol-induced liver damage (AILD) in mice.AILD was induced by oral administration ethanol (EtOH) (25%; 5 g/kg body weight) for seven days study as well EtOH-only groups.However, HGE (4 and 12 mg/kg) orally administered (once daily ten consecutive days) only to group, three prior EtOH treatment.The HGE-treated group showed significantly lower levels alanine aminotransferase aspartate than group.In...
ABSTRACT The human specific bacterial pathogen Helicobacter pylori ( H. ) is a Gram-negative microaerophilic bacterium and associated with severe gastric diseases such as peptic ulceration cancer. Recently, the increasing resistance emergence of adverse effects make usage antibiotics less effectively. Therefore, development new antimicrobial agent required to control infection. In current study, it has been demonstrated inhibitory effect β-caryophyllene on growth protective against infection...
Many of the crime scene evidences are collected by transferring body fluids that attached to surface using a tool such as sterile cotton swab or tape. The amount transferred collection directly affects possibility DNA profiling. In this study, recovery rate and detection profile were examined swabs, rubber coating agents urethane-based adhesives from porous materials. We prepared samples spraying 100㎕ diluted blood on their surface, each sample was swab, agent, adhesive, rates compared....
법미생물 검사실에서는 식품의 미생물 분석이 요구되는 경우들이 있다. 국립과학수사연구원에 식품 미생물분석이 의뢰된 샘플들 중에서 Bacillus cereus 균이 분리되었던 일부 증례가 있었다. B. 는 식중독을 일으킬 수 있는 중요한 병원성 세균이다. 따라서 우리는 최근 검사를 위해 멸치액젓에서 cereus를 분리한 후, 16S rDNA 서열을 기반으로 하는 MSId 방법 및 real-time PCR 법에 따라 균을 동정 하였다. 또한 설사 독소 유전자 구토 검출을 위한 PCR을 실시하고 분리 균주에서 nheABC, bceT entFM 유전자의 존재를 확인하였다. 임상적으로 몇 가지 식중독 세균들은 검사 시 주목해야 할 필요가 특히, 이러한 세균들 cereus는 환경저항성 내열성이 강한 내생포자를 형성하고, 내열성 독소를 형성할 수도 있기 때문에 조리된 음식을 섭취해도 본 연구를 통해서 cereus등의 세균을 구별하는 것이 식품미생물 중요함을 강조하고, 검사실에 앞으로 의뢰될...
Although technological advances have allowed the efficient collection of large amounts microbiome data for microbiological studies, proper analysis tools such big are still lacking.Additionally, analyses microbial communities using poor databases can lead to misleading results.Hence, this study aimed design an appropriate method databases.Bacteria were collected from fingertips and personal belongings (mobile phones laptop keyboards) individuals.The genomic DNA was extracted these bacteria...
Numerous methods for human body fluid identification using microbiological markers specific to different parts are well-established in forensic science. However, method vaginal screening have not been standardized yet. Therefore, this study, a real-time polymerase chain reaction based assay was devised bacteria residing vagina. This employed three markers, namely Lactobacillus iners, crispatus, and Bacteroides fragilis. L. iners crispatus were chosen due their high abundance the vagina,...