A5002391204- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- Phytochemistry and Bioactive Compounds
- Mycobacterium research and diagnosis
- Phytochemicals and Antioxidant Activities
- Veterinary medicine and infectious diseases
- Microbial Metabolites in Food Biotechnology
- Pancreatic function and diabetes
- Tuberculosis Research and Epidemiology
- Wound Healing and Treatments
- Food Quality and Safety Studies
- Microbial Applications in Construction Materials
- Metal complexes synthesis and properties
- Quinazolinone synthesis and applications
- Bacterial biofilms and quorum sensing
- Viral-associated cancers and disorders
- Synthesis and Characterization of Heterocyclic Compounds
- Polysaccharides and Plant Cell Walls
- Phytochemical compounds biological activities
- Antibiotic Resistance in Bacteria
- Bioactive Compounds and Antitumor Agents
- Ginseng Biological Effects and Applications
- Phytochemical Studies and Bioactivities
- Plant-derived Lignans Synthesis and Bioactivity
- Antimicrobial agents and applications
Kyungpook National University
2022-2025
Semyung University
2013-2022
Samsung (South Korea)
2010
The outcome after living donor renal transplantation is superior to that for deceased transplantation, but the results are not uniformly successful. factors responsible variable have been well defined.UK Transplant Registry data were analyzed determine outcomes of 3142 first adult kidney transplants from donors (71% genetically related and 29% unrelated) performed between 2000 2007 inclusive. Kaplan-Meier survival estimates determined, might be associated with graft patient using Cox...
ABSTRACT Inflammation induced by Helicobacter pylori infection related to gastric carcinogenesis. In this study, we have investigated the anti-inflammatory effect and its mechanism of kaempferol in inflammatory response caused H. vitro. We found that reduced expression pro-inflammatory cytokines (TNF-α, IL-1β, IL-8) production IL-8 AGS cells. addition, suppressed translocation cytotoxin-associated gene A (CagA) vacuolating cytotoxin (VacA) It was due decreased transcription type IV secretion...
Helicobacter pylori (H. pylori) classified as a class I carcinogen by the World Health Organization (WHO) plays an important role in progression of chronic gastritis and development gastric cancer. A major bioactive component Evodia rutaecarpa, evodiamine, has been known for its anti-bacterial effect anti-cancer effects. However, inhibitory evodiamine against H. is not yet mechanisms cancer cells are to be elucidated concretely. In this study, therefore, on growth well anti-inflammatory...
Piperine is a compound comprising 5-9% of black pepper (Piper nigrum), which has variety biological roles related to anticancer activities. Helicobacter pylori been classified as gastric carcinogen, because it causes gastritis and cancer by injecting the virulent toxin CagA translocating VacA. The present study investigated inhibitory action piperine on H. growth adhesion. Inhibition was determined broth macrodilution method, adhesion adenocarcinoma cells validated urease assay. Motility...
The human specific bacterial pathogen Helicobacter pylori (H. pylori) is associated with severe gastric diseases, including cancer. Recently, the increasing resistance makes usage of antibiotics less effectively. Therefore, development a new antimicrobial agent required to control H. infection. In current study, inhibitory effect β-caryophyllene on growth, as well antibacterial therapeutic effect, has been demonstrated. inhibited growth via downregulation dnaE, dnaN, holB, and gyrA also...
H. pylori is classified as a group I carcinogen by WHO because of its involvement in gastric cancer development. Several reports have suggested anti-bacterial effects menadione, although the effect menadione on major virulence factors and pylori-induced inflammation yet to be elucidated. In this study, therefore, we demonstrated that has anti-H. anti-inflammatory effects. Menadione inhibited growth reference strains clinical isolates. reduced expression vacA pylori, translocation VacA...
Helicobacter pylori (H. pylori) is a bacterium known to infect the human stomach. It can cause various gastrointestinal diseases including gastritis and gastric cancer. Hesperetin major flavanone component contained in citrus fruits. has been reported possess antibacterial, antioxidant, anticancer effects. However, antibacterial mechanism of hesperetin against H. not yet. Therefore, objective this study was determine inhibitory effects on growth its mechanisms. The results showed that...
Helicobacter pylori (H. pylori) produces urease in order to improve its settlement and growth the human gastric epithelium. Urease inhibitors likely represent potentially powerful therapeutics for treating H. pylori; however, their instability toxicity have proven problematic clinical trials. In this study, we investigate ability of a natural compound extracted from Zingiber zerumbet Smith, zerumbone, inhibit activity by formation dimers, trimers, or tetramers. As an oxygen atom possesses...
Eight novel heteroleptic HfIV complexes containing differently substituted 2-picolylamino-bis-phenolate and 2,6-dipicolinic acid (Dipic) groups as chelating ligands were synthesized characterized with yields higher than 80%. These [ONON] type have good aqueous stability potent anti-tumor activity against HeLa S3 (human cervical adenocarcinoma) Hep G2 derived hepatoma) cells. In particular, the demonstrated selective inhibitory The IC50 value of most cytotoxic complex [L1HfIVDipic4-Cl] (0.9 ±...
Black rice extract (BRE) contains cyanidin 3-O-glucoside (C3G), an anthocyanin, as the major component. In this study, we found that BRE inhibits mRNA and protein expression of genes encoding cytotoxin-associated A (cagA) vacuolating (vacA) in Helicobacter pylori 60190 strain. We performed RT-PCR western blotting to show SecA. Because SecA is involved VacA export bacteria, our result suggests a positive correlation between BRE-induced inhibition secA secretion. Further, perform MTT assay...
Herein, the synthesis of M( ii ) (M = Co, Cu, Zn, and Cd) complexes with morpholine-derived ligand is described that has shown significant urease inhibition, along promising antioxidant anticancer potential.
Extracts from barley seedlings (BS) have known antioxidant and anti-inflammatory activities. The flavonoid lutonarin (LN) is a component of BS extract has several bioactivities. Here, we evaluated LN efficacy against lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Lutonarin was isolated by methanol extraction characterized ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS). did not reduce the viability or enhance apoptosis...
Infection of Helicobacter pylori on gastric mucosa is associated with various diseases.According to the WHO, H. causes cancer and has been classified as a class I carcinogen.Riboflavin an essential vitamin which presents in wide variety foods.Previous studies have shown that riboflavin/UVA was effective against growth inhibition Staphylococcus aureus, S. epidermidis multidrug-resistant Pseudomonas aeruginosa had potential for antimicrobial properties.Thus, we hypothesized riboflavin role...
Regulatory T cells (Treg), known as immune-suppressors, may help modulate the immune response. In this study, we investigated effect of Treg-derived TGF-β1 on pancreatic islet cell function in vitro and vivo. One hundred eighty IEQ (islet equivalents) islets, marginal amount to regulate blood glucose level after syngeneic transplantation mouse type 1 diabetes (T1D) model, were co-cultured with 4×106 Treg for 48 hours. The changes TGF-β1, interleukin-6 (IL-6), insulin secretion levels...
Some virulence proteins of Helicobacter pylori, such as vacuolating cytotoxic protein A (VacA) and cytotoxin-associated gene (CagA) have been reported to be causative agents various gastric diseases including chronic gastritis, ulcer or adenocarcinoma. The expression level these can regulated when H. pylori is exposed the antibacterial agent, cyanidin 3-O-glucoside (C3G) previously reported. In this study, we analyzed quantitative change CagA VacA by C3G treatment. We used 2-dimensional...