A5060823244- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Bioactive natural compounds
- Phytochemistry and Bioactive Compounds
- Curcumin's Biomedical Applications
- Phytochemical Studies and Bioactivities
- Natural Compounds in Disease Treatment
- Peroxisome Proliferator-Activated Receptors
- Plant Toxicity and Pharmacological Properties
- Phytochemical compounds biological activities
- Biochemical Analysis and Sensing Techniques
- Marine Toxins and Detection Methods
- Traditional and Medicinal Uses of Annonaceae
- Pharmacological Effects of Natural Compounds
- NF-κB Signaling Pathways
- Alkaloids: synthesis and pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant-based Medicinal Research
- Biological and pharmacological studies of plants
- Biological Activity of Diterpenoids and Biflavonoids
- Adipokines, Inflammation, and Metabolic Diseases
- Microbial Natural Products and Biosynthesis
- Bioactive Compounds and Antitumor Agents
- Genomics, phytochemicals, and oxidative stress
- Malaria Research and Control
Shanghai University of Traditional Chinese Medicine
2016-2025
Shanghai University
2012-2015
State Administration of Traditional Chinese Medicine of the People's Republic of China
2015
Xinjiang Institute of Materia Medica
2015
Institute of Chinese Materia Medica
2015
Florida International University
2009-2012
Shanghai Institutes for Biological Sciences
2005-2006
GTx (United States)
2006
Shanghai Institute of Materia Medica
1999-2006
Chinese Academy of Sciences
2005-2006
C-glycosylflavonoids are characterized by a bond between the anomeric carbon of sugar moiety and C-6 or C-8 position flavonoid A ring. These compounds widespread in nature have become subject increasing research interest due to their high biological potential. This review focuses on effects various structure–activity relationships (SAR) as elucidated over last 5 years.
Spatholobus suberectus Dunn, belonging to the legume family (Fabaceae), has been used as a Traditional Chinese Medicine for treatment of anemia, menoxenia and rheumatism. A limited number studies report that various types flavonoids are main characteristic constituents this herb. We have now found S. contains about 2% phenolic components characterized major homogeneous B-type procyanidin conjugates using liquid chromatography with diode-array detection-ESI mass spectrometry (LC-DAD/ESI-MS)...
Context: Sea cucumbers have been consumed as tonic, food, and nutrition supplements for many years.Objective: The objective of this study is to investigate the antiobesity lipid-lowering effects sea cucumber extracts in vitro vivo models elucidate mechanism action on obesity dyslipidemia.Materials methods: 60% ethanol from body walls 10 different were investigated inhibition pancreatic lipase (PL) activity vitro. optimal active extract (SC-3) was further chemically analyzed by LC-MS UV. And...
Scope Inhibiting human neutrophil elastase (HNE) is a promising strategy for treating inflammatory lung diseases, such as H1N1 and SARS virus infections. The use of sivelestat, the only clinically registered synthesized HNE inhibitor, largely limited by its risk organ toxicity because it irreversibly inhibits HNE. Therefore, potent reversible inhibitors are alternatives to sivelestat. Methods Results An in vitro inhibition assay was employed screen series triterpenes. Six pentacyclic...
A total of 16 sesquiterpenes were isolated from the rhizomes Curcuma wenyujin, including four undescribed sesquiterpenes, namely wenyujinone J – M (1 4), and twelve known molecules (5 16). The structures compounds elucidated based on spectroscopic spectrometric data analyses. Among them, wenyujinones (1) L (3) possessed sesquiterpenoid skeletons. In addition, all evaluated for their protective effect against hydrogen peroxide (H2O2)‐induced injury in human hepatic L02 cells agonistic...
Abstract Pancreatic cancer remains one of the most lethal malignancies in digestive system, with limited available drugs and a need for improved efficacy. This unmet clinical highlights urgency to discover novel, highly efficient small‐molecule compounds. Herein, novel cyano‐containing artemisinin dimer derivative, ZQJ29, is synthesized through structural modifications artemisinin. Biological evaluation demonstrated that ZQJ29 effectively inhibits proliferation pancreatic cells both vitro...
Obesity is a global health problem. In the past decades, prevalence rate of obesity has risen sharply in epidemiology. become an increasingly severe epidemic burden linked with different kinds diseases, consisting cardiovascular disease, diabetes, metabolic associated fatty liver and even COVID-19. Beneficial flavonoids foods, as functional ingredients, combat maintain energy balance through multiple mechanisms. This review provides brief overview biological targets, possible mechanisms...
Abstract Peroxisome proliferator‐activated receptor γ (PPARγ) agonists have been used for the treatment of diabetes with effect lowering blood glucose levels and improving insulin sensitivity. Natural compounds such as flavones, flavanones, isoflavones shown excellent PPARγ agonist activity. In this study, analogues bavachinin were designed, synthesized, evaluated by reporter gene assays Preliminary structure–activity relationships these summarized, seven found to higher activities than...