Abstract Background Contagious Ovine Digital Dermatitis (CODD) is an emerging and common infectious foot disease of sheep which causes severe welfare economic problems for the industry. The aetiology not fully understood control problematic. aim this study was to investigate polybacterial aetiopathogenesis CODD effects antibiotic treatment, in a longitudinal experimentally induced outbreak using 16S rRNA gene amplicon sequencing approach. Results 15/30 experimental sheep. During development...

A novel bacterium, strain Ru1T, was encountered during a survey of spirochaetes living in the gastrointestinal tract ruminants. Comparative analysis 16S rRNA gene sequence data indicated that Ru1T clustered within genus Treponema but shared at most 86.1 % similarity with other recognised species . Further phylogenetic based on partial recombinase (recA) comparisons, together phenotypic characterization, also demonstrated divergence from Microscopically, appeared as very small, highly motile,...

Contagious ovine digital dermatitis (CODD) is a severe and common infectious foot disease of sheep significant animal welfare issue for the industry in UK some European countries. The etiology pathogenesis are incompletely understood. In this longitudinal, experimental study, CODD was induced 18 sheep, first time, clinical lesion development associated microbiological changes affected feet described over resulting completely new understanding etiopathogenesis CODD. majority lesions (83.9%)...

Background Non‐healing bovine foot lesions, including non‐healing white line disease, sole ulcer and toe necrosis, are an increasingly important cause of chronic lameness that poorly responsive to treatment. Recent studies have demonstrated a high‐level association between these lesions the Treponema phylogroups implicated in digital dermatitis (BDD). However, polymicrobial aetiology involving other gram‐stain‐negative anaerobes is suspected. Methods A PCR‐based bacteriological survey...

Here, we report the first complete genomes of three cultivable treponeme species from bovine digital dermatitis (DD) skin lesions, two comparative human treponemes, considered indistinguishable DD species, and a gastrointestinal (GI) isolate. Key genomic differences between treponemes implicate microbial mechanisms that enhance knowledge how DD, severe disease ruminants, has emerged into prolific, worldwide disease. Bovine have additional oxidative stress genes compared to nearest...

Abstract Background Bovine digital dermatitis (BDD) is an infectious foot disease found commonly in dairy herds. Foot-trimming important husbandry procedure for reducing the ensuing lameness; however, epidemiological, and microbiological studies have identified this as a risk activity transmitting BDD. Three disinfectants previously been laboratory work effective removing viable BDD-associated Treponema spp., from hoof knife blades. The present study enrolled 133 cattle with BDD lesions,...

Leptospirosis is a zoonotic bacterial disease affecting mammalian species worldwide. Cattle are major susceptible host; infection with pathogenic Leptospira spp. represents public health risk and results in reproductive failure reduced milk yield, causing economic losses. The characterisation of outer membrane proteins (OMPs) from disease-causing bacteria dissects pathogenesis underpins vaccine development. As most leptospire research has focused on interrogans, this study aimed to...

A Gram-stain-negative, obligatory anaerobic spirochete, CHPAT, was isolated from the rectal tissue of a Holstein–Friesian cow. On basis 16S rRNA gene comparisons, CHPAT most closely related to human oral Treponema parvum , with 88.8 % sequence identity. Further characterisation on recA analysis, cell morphology, pattern growth and physiological profiling identified marked differences respect other recognised species genus . Microscopically, helical cells measured approximately 1–5 µm long...

Abstract Contagious ovine digital dermatitis (CODD) is a significant disease of the foot characterised by severe lameness and progressive separation hoof horn capsule from underlying tissue. Similar to bovine (BDD), pathogenic members genus Treponema including medium phylogroup, phagedenis phylogroup pedis are frequently found together in CODD lesions. To date, was only described Ireland United Kingdom. In northern Germany, cases an unusually presented sheep flock that had been affected...

Bovine digital dermatitis (BDD), an infectious disease of the bovine foot with a predominant treponemal etiology, is leading cause lameness in dairy and beef herds worldwide. BDD poorly responsive to antimicrobial therapy exhibits relapsing clinical course; effective vaccine therefore urgently sought. Using reverse vaccinology approach, present study surveyed genomes three BDD-associated Treponema phylogroups for putative β-barrel outer membrane proteins considered their potential as...

Contagious ovine digital dermatitis (CODD) causes a severe, infectious foot disease and lameness of sheep, is common within the UK now also emerging in other countries. As well as causing severe animal welfare issues, huge economic losses emerge from due to weight loss/lack gain, veterinary treatments. CODD lesion progress measured, with scoring system 1 (early lesions) 5 (healed). Here, using samples an experimental flock infected by natural means, were taken stage lesions, post treatment,...

Keratoma is an aberrant keratin mass thought to originate from epidermal horn-producing cells interposed between the stratum medium of hoof wall and underlying third phalanx. The cause unknown, although presence keratomas frequently associated with chronic irritation, focal infection, or trauma. A total 167 donkeys were presented in this study. diagnosis a keratoma was based on clinical signs, radiography, histopathologic examination. Surgical excision attempted all lameness unless...

Abstract Background: Contagious Ovine Digital Dermatitis (CODD) is an emerging and common infectious foot disease of sheep which causes severe welfare economic problems for the industry. The aetiology not fully understood control problematic. aim this study was to investigate polybacterial aetiopathogenesis CODD effects antibiotic treatment, in a longitudinal experimentally induced outbreak using 16S rRNA gene amplicon sequencing approach. Results: 15/30 experimental sheep. During...

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Here we report an outbreak of atypical, ulcerative dermatitis in North Country mule lambs, located South Gloucestershire, UK. The lesions, which appeared to be contagious, occured between the coronary band and carpal joint as a focal, well demarcated, circular, dermatitis. Histopathological examination lesion biopsies revealed areas ulceration, epidermal hyperplasia, suppurative granulation tissue. Clumped keratohyalin granules intracellular keratinocyte oedema (ballooning degeneration) were...

Abstract This research communication reports the results from questionnaires used to identify impact of recent into disinfection cattle foot-trimming equipment prevent bovine digital dermatitis (BDD) transmission on (a) biosecurity knowledge and (b) hygiene practice foot health professionals. An initial questionnaire found that more than half participating farmers, veterinary surgeons commercial foot-trimmers were not considering hand or hoof-knife in their working practices. The following...

Lameness in sheep is one of the most serious issues on farms UK and worldwide, affecting over 90% all flocks. Despite its severity prevalence, there are knowledge gaps regarding transmission routes bacterial pathogens associated with infectious lameness sheep. As larvae Lucilia sericata commonly found foot lesions lame sheep, it was hypothesised that flies or their could harbour bacteria. This study examined gut contents obtained from compared them to control collected infested cat food same...