A5038027662- Animal Behavior and Welfare Studies
- Animal Disease Management and Epidemiology
- Animal Virus Infections Studies
- Veterinary Oncology Research
- Nail Diseases and Treatments
- Poxvirus research and outbreaks
- Microbial infections and disease research
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Syphilis Diagnosis and Treatment
- Insect symbiosis and bacterial influences
- Parvovirus B19 Infection Studies
- Plant and Fungal Interactions Research
- Vector-borne infectious diseases
- Reproductive tract infections research
- Parasite Biology and Host Interactions
- Forensic Entomology and Diptera Studies
- Wound Healing and Treatments
- Mycobacterium research and diagnosis
- Food Allergy and Anaphylaxis Research
- Insect and Pesticide Research
- Parasites and Host Interactions
- Mast cells and histamine
- Leptospirosis research and findings
University of Lincoln
2018-2024
University of Liverpool
2011-2024
ABSTRACT Since 2008, a large increase in the numbers of cases lameness have been seen wild North American elk ( Cervus elaphus ) from Washington State, USA. The most recent manifested as foot lesions similar both clinically and pathologically to those digital dermatitis (DD) cattle sheep, disease with bacterial etiopathogenesis. To determine whether same bacteria considered responsible for DD are associated lameness, lesion samples were subjected isolation studies PCR assays three...
Contagious ovine digital dermatitis (CODD) is an important foot disease in sheep, with significant animal welfare and economic implications. It thought that CODD emerged from bovine (BDD) via treponemal bacteria. With wildlife species such as elk now suffering a CODD-like disease, it imperative to clarify these etiologies. A large investigation into association warranted. lesions (n = 58) healthy sheep tissues 56) were analyzed by PCR for the three BDD-associated Treponema phylogroups two...
A UK dairy goat herd was assessed after reports of a severe lameness problem unknown aetiology. prevalence estimate produced and individual clinical examination 15 randomly selected lame goats performed. Fifteen animals had foot lesions closely resembling contagious ovine digital dermatitis (CODD) in sheep. Eight the examined presented with typical CODD seven showed what appeared to be more under‐running sole. Ten biopsy samples were obtained from tested by PCR for three previously isolated...
Canine parvovirus (CPV) and canine enteric coronavirus (CECoV) are often cited as causes of diarrhoea in dogs. This study aimed to determine the prevalence CPV CECoV dogs presenting with severe PDSA PetAid hospitals throughout UK. A total 355 samples were collected from between 2006 2008. All tested for using a long range PCR RT‐PCR. The was 58 per cent (95 confidence interval [CI] 52 63 cent), some evidence regional variation. 7.9 CI 5.1 10.7 cent). Analysis showed that animals no history...
ABSTRACT Canine parvovirus type 2 (CPV-2) is a severe enteric pathogen of dogs, causing high mortality in unvaccinated dogs. After emerging, CPV-2 spread rapidly worldwide. However, there now some evidence to suggest that international transmission appears be more restricted. In order investigate the and evolution both nationally relation global situation, we have used long-range PCR amplify sequence full VP2 gene 150 canine parvoviruses obtained from large cross-sectional sample dogs...
ABSTRACT Treponema species are implicated in many diseases of humans and animals. Digital dermatitis (DD) treponemes reported to cause severe lesions cattle, sheep, pigs, goats, wild elk, causing substantial global animal welfare issues economic losses. The fastidiousness these spirochetes has previously precluded studies investigating within-phylogroup genetic diversity. An archive that we isolated enabled multilocus sequence typing quantify the diversity population structure DD treponemes....
Treponeme-associated foot disease has been described in cattle with digital dermatitis and sheep contagious ovine dermatitis. In this study, severe lesions dairy goats associated treponemes (i.e. Treponema medium, phagedenis pedis) were characterized macroscopically, radiographically histologically. The main macroscopic lesion was of extensive solar ulceration or without exophytic papilliform hyperkeratosis. Radiographically, the distal phalanx sesamoid bones severely damaged remodelled....
A recent outbreak of ischaemic teat necrosis (ITN) on mainland UK has resulted in large economic losses for dairy farmers. Typical cases start as an area dry, thickened and encrusted skin the medial aspect base teat, where joins udder, often with a fetid odour. The erosion spreads down causing intense irritation, which turn leads to more severely affected animals removing entire teat. Due severity ITN substantial costs industry, analyses were undertaken ascertain if infectious agent might be...
A novel bacterium, strain Ru1T, was encountered during a survey of spirochaetes living in the gastrointestinal tract ruminants. Comparative analysis 16S rRNA gene sequence data indicated that Ru1T clustered within genus Treponema but shared at most 86.1 % similarity with other recognised species . Further phylogenetic based on partial recombinase (recA) comparisons, together phenotypic characterization, also demonstrated divergence from Microscopically, appeared as very small, highly motile,...
Contagious ovine digital dermatitis (CODD) is a severe and common infectious foot disease of sheep significant animal welfare issue for the industry in UK some European countries. The etiology pathogenesis are incompletely understood. In this longitudinal, experimental study, CODD was induced 18 sheep, first time, clinical lesion development associated microbiological changes affected feet described over resulting completely new understanding etiopathogenesis CODD. majority lesions (83.9%)...
Abstract A 2022 canine gastroenteritis outbreak in the United Kingdom was associated with circulation of a new enteric coronavirus closely related to 2020 variant an additional spike gene recombination. The variants are unrelated coronavirus–like viruses human disease but represent model for population adaptation.
Bovine hock lesions present a serious welfare and production issue on dairy farms worldwide. Current theories suggest that trauma is an important factor in the formation of lesions, although infection may also play role increasing their severity duration.Digital dermatitis (DD) cows are strongly associated with specific treponeme bacteria which opportunistic invaders other skin regions. Hock were tested to ascertain if they too contained treponemes.Swab tissue samples taken from two South...
Both contagious ovine digital dermatitis (CODD) and bovine (BDD) are causes of infectious lameness in sheep cattle, respectively, strongly associated with the presence specific treponemes, three different cultivable phylogroups commonly isolated: Treponema medium , phagedenis pedis . The aim this study was to investigate potential transmit CODD‐associated species via gloves used when handling visibly clinically affected animals. feet without CODD were handled as part routine examination...
Background Contagious ovine digital dermatitis ( CODD ) is an important cause of infectious lameness in sheep the UK and Ireland has a severe impact on welfare affected individuals. The three treponemal phylogroups Treponema medium/Treponema vincentii ‐like, phagedenis ‐like pedis spirochaetes have been associated with clinical lesions are considered to be necessary disease. There scant data antimicrobial susceptibility treponemes cultured from lesions. Objective aim this study was determine...
Here, we report the first complete genomes of three cultivable treponeme species from bovine digital dermatitis (DD) skin lesions, two comparative human treponemes, considered indistinguishable DD species, and a gastrointestinal (GI) isolate. Key genomic differences between treponemes implicate microbial mechanisms that enhance knowledge how DD, severe disease ruminants, has emerged into prolific, worldwide disease. Bovine have additional oxidative stress genes compared to nearest...
Avian endoparasites play important roles in conservation, biodiversity and host evolution. Currently, little is known about the epidemiology of intestinal helminths protozoans infecting wild birds Britain Ireland. This study aimed to determine rates parasite prevalence, abundance infection intensity passerines. Fecal samples (n = 755) from 18 bird families were collected 13 sites across England, Wales Ireland March 2020 June 2021. A conventional sodium nitrate flotation method allowed...
A Gram-stain-negative, obligatory anaerobic spirochete, CHPAT, was isolated from the rectal tissue of a Holstein–Friesian cow. On basis 16S rRNA gene comparisons, CHPAT most closely related to human oral Treponema parvum , with 88.8 % sequence identity. Further characterisation on recA analysis, cell morphology, pattern growth and physiological profiling identified marked differences respect other recognised species genus . Microscopically, helical cells measured approximately 1–5 µm long...
This short study describes the occurrence of pathogenic Leptospira spp. in two major wet markets Kota Bharu, Kelantan, Malaysia.30 rodents (20 rats and 10 shrews) were caught 2 markets, a postmortem was performed to extract both kidneys. Molecular diagnosis via polymerase chain reaction (PCR) conducted detect leptospiral DNA using universal primers, respectively.The results showed that 20/28 (72%) rat samples detected positive for spp, all shrews negative. Further sequencing analysis...
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