A5083884637- Plant Reproductive Biology
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Sphingolipid Metabolism and Signaling
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Plant Surface Properties and Treatments
- Lipid Membrane Structure and Behavior
- Insect and Arachnid Ecology and Behavior
- PI3K/AKT/mTOR signaling in cancer
- Assisted Reproductive Technology and Twin Pregnancy
- Inhalation and Respiratory Drug Delivery
- Medical Imaging and Pathology Studies
- Advanced MRI Techniques and Applications
- Plant Parasitism and Resistance
- Neurotransmitter Receptor Influence on Behavior
- Congenital heart defects research
- Atomic and Subatomic Physics Research
- Animal Genetics and Reproduction
- Neonatal Respiratory Health Research
- Plant nutrient uptake and metabolism
- Reproductive Biology and Fertility
- Asthma and respiratory diseases
- Bipolar Disorder and Treatment
- Advanced NMR Techniques and Applications
- Reproductive Health and Technologies
Idorsia (Switzerland)
2018-2025
Siemens Healthcare (Germany)
2023
University of Zurich
1999-2017
Carnegie Institution for Science
2016
Carnegie Department of Plant Biology
2004-2016
Actelion (Switzerland)
2016
California Institute of Technology
2005-2007
Stanford University
2004
Nara Institute of Science and Technology
2004
University of Fribourg
2000
In plants, members of microRNA (miRNA) families are often predicted to target the same or overlapping sets genes. It has thus been hypothesized that these miRNAs may act in a functionally redundant manner. This hypothesis is tested here by studying effects elimination all three MIR164 family from Arabidopsis. was found loss miR164 activity leads severe disruption shoot development, contrast effect mutation any single gene. indicates indeed redundant. Differences expression patterns...
Sexual reproduction is a salient aspect of plants, and elaborate structures, such as the flowers angiosperms, have evolved that aid in this process. Within flower corresponding sex organs, anther ovule, form male female sporangia, pollen sac nucellus, respectively. However, despite their central role for sexual little known about mechanisms control establishment these important structures. Here we present identification molecular characterization NOZZLE (NZZ) gene flowering plant Arabidopsis...
A major structural component of the cuticle plants is cutin. Analysis function cutin in vivo has been limited because no mutants with specific defects have characterized. Therefore, transgenic Arabidopsis were generated that express and secrete a cutinase from Fusarium solani f sp pisi. expressing extracellular space showed an altered ultrastructure enhanced permeability to solutes. In addition, pollen could germinate on fully differentiated leaves cutinase-expressing but not control leaves....
The biogenic amine serotonin (5-HT) is a multi-faceted hormone that synthesized from dietary tryptophan with the rate limiting step being catalyzed by enzyme hydroxylase (TPH). therapeutic potential of peripheral 5-HT synthesis inhibitors has been demonstrated in number clinical and pre-clinical studies diseases including carcinoid syndrome, lung fibrosis, ulcerative colitis obesity. Due to long half-life blood lung, changes steady-state levels are slow manifest themselves. Here,...
In the progression phase of idiopathic pulmonary fibrosis (IPF), normal alveolar structure lung is lost and replaced by remodeled fibrotic tissue bronchiolized cystic airspaces. Although these are characteristic features IPF, knowledge specific interactions between pathological processes limited. Here, interaction epithelial mesenchymal cells was investigated in a coculture model human primary airway (EC) fibroblasts (FB). Single-cell RNA sequencing revealed that starting EC population...
The gravitropism defective 2 (grv2) mutants of Arabidopsis show reduced shoot phototropism and gravitropism. Amyloplasts in the endodermal cells grv2 do not sediment to same degree as wild type. GRV2 gene encodes a 277-kD polypeptide that is 42% similar Caenorhabditis elegans RME-8 protein, which required for endocytosis. We hypothesize defect endocytosis may affect both initial gravity sensing via amyloplasts sedimentation subsequent more general tropic growth response.
Abstract Plant lateral organs exhibit proximal-distal and adaxial-abaxial polarity. In Arabidopsis, abaxial cell fate is regulated in part by putative transcription factors of the YABBY family, such as FILAMENTOUS FLOWER (FIL) INNER NO OUTER (INO), a mechanism that currently not fully understood. NOZZLE (NZZ) encodes plant-specific nuclear protein. Genetic evidence has shown NZZ involved positive feedback regulation INO, thereby acting both temporal spatial repressor INO transcription. This...
Pulmonary fibrosis encompasses different chronic interstitial lung diseases, and the predominant form, idiopathic pulmonary fibrosis, remains to have a poor prognosis despite 2 approved therapies. Although exact pathobiological mechanisms are still incompletely understood, epithelial injury aberrant wound healing responses contribute gradual change in architecture functional impairment. Lysophosphatidic acid (LPA)-induced lysophosphatidic receptor 1 (LPA1) signaling was proposed be driver of...
Pathological features of pulmonary fibrosis include accumulation myofibroblasts and increased extracellular matrix (ECM) deposition in lung tissue. Contractile α-smooth muscle actin (α-SMA)-expressing that produce secrete ECM are key effector cells the disease therefore represent a viable target for potential novel anti-fibrotic treatments. We used primary normal human fibroblasts (NHLF) two high-throughput screening assays to discover molecules inhibit or revert fibroblast-to-myofibroblast...
Cytokinesis in plants involves the formation of unique cellular structures such as phragmoplast and cell plate, both which are required to divide after nuclear division. In order isolate genes that involved de novo wall formation, we performed a large-scale, microscope-based screen for Arabidopsis mutants severely impair cytokinesis embryo. We recovered 35 mutations form abnormally enlarged cells with multiple, often polyploid nuclei incomplete walls. These represent seven genes, four have...
A major structural component of the cuticle plants is cutin.Analysis function cutin in vivo has been limited because no mutants with specific defects have characterized.Therefore, transgenic Arabidopsis were generated that express and secrete a cutinase from Fusarium solani f sp pisi .Arabidopsis expressing extracellular space showed an altered ultrastructure enhanced permeability to solutes.In addition, pollen could germinate on fully differentiated leaves cutinase-expressing but not...
The Iseult project started in 2001 and is a collaborative effort involving CEA the University of Freiburg academics, Guerbet, Siemens Healthineers Bruker Biospin as industrial partners. One central aspect has been design by whole-body magnet 11.7T field strength with 90-cm wide bore. After nearly 20 years research development, prototyping, integration tests, first images have acquired this unique MRI scanner. Some key validation results are presented here.