A5101598095- Genetic Mapping and Diversity in Plants and Animals
- Wheat and Barley Genetics and Pathology
- Plant Stress Responses and Tolerance
- Genetics and Plant Breeding
- Air Quality and Health Impacts
- MicroRNA in disease regulation
- Plant Molecular Biology Research
- Rice Cultivation and Yield Improvement
- Photosynthetic Processes and Mechanisms
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Climate Change and Health Impacts
- RNA modifications and cancer
- Vitamin D Research Studies
- Crop Yield and Soil Fertility
- Bone health and osteoporosis research
- GABA and Rice Research
- Genetic factors in colorectal cancer
- Melamine detection and toxicity
- Zebrafish Biomedical Research Applications
- Environmental DNA in Biodiversity Studies
- Light effects on plants
- Cellular Mechanics and Interactions
- Genomics and Phylogenetic Studies
- Plant Reproductive Biology
Zhejiang A & F University
2017-2024
University of California, San Diego
2024
Zhejiang Chinese Medical University
2023-2024
ZheJiang Academy of Agricultural Sciences
2017
Huazhong Agricultural University
2007-2016
Washington University in St. Louis
2006-2013
University of Illinois Chicago
2009-2010
Aarhus University Hospital
2000
Significance New discoveries have been continuously made in recent years on the roles of noncoding RNAs regulating biological processes. Phased small-interfering (phasiRNAs) may be newest member discovered years. The photoperiod-sensitive male sterility (PSMS) rice is a very valuable germplasm that started era two-line hybrid rice. Here we show phasiRNAs generated by long-noncoding RNA PMS1T encoded Pms1 locus regulates PSMS This work provides case associating with trait, especially an...
Abstract Tumor metastasis is the dominant cause of death in cancer patients, including patients with oral tongue squamous cell carcinoma (TSCC). Previously, we reported that reduced miR‐138 level correlated enhanced metastatic potential TSCC cells. Here, demonstrate suppresses migration and invasion by regulating 2 key genes Rho GTPase signaling pathway: RhoC ROCK2. Direct targeting to specific sequences located 3′‐untranslated regions both ROCK2 mRNAs was confirmed using luciferase reporter...
Abstract Wheat is a major food crop worldwide. The plant architecture complex trait mostly influenced by height, tiller number, and leaf morphology. Plant height plays crucial role in lodging thus affects yield grain quality. In this study, wheat population was genotyped using Illumina iSelect 90K single nucleotide polymorphism (SNP) assay finally 22,905 high-quality SNPs were used to perform genome-wide association study (GWAS) for architectural traits employing four multi-locus GWAS...
Deregulations of microRNA have been frequently observed in tongue squamous cell carcinoma (TSCC), but their roles tumorigenesis are not entirely clear. Here, we reported the up‐regulation miR‐24 TSCC. MiR‐24 reduced expression RNA‐binding protein dead end 1 (DND1). Knockdown led to enhanced DND1. The direct targeting DND1 mRNA was predicted bioinformatically and confirmed by luciferase reporter gene assays. Furthermore, miR‐24‐mediated change suppressed cyclin‐dependent kinase inhibitor 1B...
Background: Observational studies suggest a potential association between atmospheric particulate matter 2.5 (PM2.5) and osteoporosis, but causal is unclear due to the presence of confounding factors. Methods: We utilized bone mineral density indices at four specific sites represent osteoporosis: femoral neck (FN-BMD), lumbar spine (LS-BMD), forearm (FA-BMD), heel (HE-BMD). The PM2.5 data was obtained from UK Biobank database, while datasets for FN-BMD, LS-BMD, FA-BMD were GEFOS dataset...
The fetal liver kinase 1 (FLK-1)(+) hemangioblast can generate hematopoietic, endothelial, and smooth muscle cells (SMCs). ER71/ETV2, GATA2, SCL form a core transcriptional network in development. Transient coexpression of these three factors during mesoderm formation stage mouse embryonic stem (ESCs) robustly enhanced generation by activating bone morphogenetic protein (BMP) FLK-1 signaling while inhibiting phosphatidylinositol 3-kinase, WNT signaling, cardiac output. Moreover, etsrp,...
Mitochondrial tumor suppressor gene 1 (MTUS1) has been recently identified as a candidate which resides in genomic region (8p22) that shows frequent loss of heterozygosity (LOH) several types. It suggested multiple promoters and alternative splicing lead to the expression 5 known MTUS1 transcript variants. Here, we characterized 5' untranslated regions different We also cloned functionally tested alternatively utilized contribute production Our results confirmed early hypothesis variants are...
Abstract As the progenitor of durum wheat ( Triticum Desf.) and common T. aestivum L.), wild emmer turgidum L. subsp. dicoccoides , TTD) has many valuable alleles for enlarging genetic pool wheat. Chromosome arm substitution lines (CASLs) are useful resources producing genome‐wide variations in background certain cultivars, with each CASL containing a pair an individual chromosome arms from donor parent. Therefore, CASLs can be used to identify broad range phenotypes that usually different...
High-altitude populations exhibit distinct cellular, respiratory, and cardiovascular phenotypes, some of which provide adaptive advantages to hypoxic conditions compared with sea-level ancestry. Studies performed in a history high-altitude residence, such as Tibetans, support the idea that many these phenotypes may be shaped by genomic features have been positively selected for throughout generations. We hypothesize traits observed Tibetans at high altitude also occur living intermediate...
qRT-PCR is one of the widely used methods for analysing expression levels specific genes, which requires reliable experimental results with aid stably-expressed reference genes. Although there are some common housekeeping many experiments have proved that these genes can change under different conditions. Heat stress key factors affecting rice yield and quality, relatively few reports be heat research. To find stably expressed stress, this experiment analysed 10 new candidate by to explore...
Abstract Background In observational studies, the 25-hydroxyvitamin D (25(OH)D) level in body has been found to be closely related Particulate matter air pollution (PM). this study, we employed two-sample Mendelian randomization method (MR) investigate and discuss potential causal relationship mode of influence. Methods PM data (PM 10 , 2.5−10 2.5, 2.5 absorbance) came from UKBiobank database 25(OH)D EBI database. The analysis was conducted utilizing three prominent methods (Inverse-variance...
Abstract Background: Wheat is a staple food crop worldwide. Plant height key factor in plant architecture as it plays crucial role lodging and thus affects yield quality. Genome-wide studies are mostly applied plants, due to its advanced genotyping technologies, identification of novel loci, improved statistical approaches. Results: In this study, the population was genotyped by using Illumina iSelect 90K single nucleotide polymorphism (SNP) assay finally 22,905 high-quality SNPs were used...