A5043062345- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Pituitary Gland Disorders and Treatments
- Epigenetics and DNA Methylation
- Cardiac Valve Diseases and Treatments
- Head and Neck Surgical Oncology
- Infective Endocarditis Diagnosis and Management
- Growth Hormone and Insulin-like Growth Factors
- Spinal Fractures and Fixation Techniques
- Meningioma and schwannoma management
- Advanced Sensor and Energy Harvesting Materials
- Caveolin-1 and cellular processes
- Cancer Mechanisms and Therapy
- Cerebrospinal fluid and hydrocephalus
- Cardiovascular Function and Risk Factors
- Spinal Dysraphism and Malformations
- Neuroscience and Neural Engineering
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Neurosurgical Procedures and Complications
Southern Medical University
2016-2025
Nanfang Hospital
2016-2025
University of Illinois Urbana-Champaign
2025
Fudan University
2015-2025
Zhongshan Hospital
2019-2025
Sun Yat-sen University
2019-2025
The First Affiliated Hospital, Sun Yat-sen University
2019-2025
Second Affiliated Hospital of Shantou University Medical College
2025
Shantou University
2025
Pennsylvania State University
2022-2024
An accurate extraction of physiological and physical signals from human skin is crucial for health monitoring, disease prevention, treatment. Recent advances in wearable bioelectronics directly embedded to the epidermal surface are a promising solution future sensing. However, existing susceptible motion artifacts as they lack proper adhesion conformal interfacing with during motion. Here, we present ultra-conformal, customizable, deformable drawn-on-skin electronics, which robust due strong...
Chemoresistance to temozolomide (TMZ) is a major challenge in the treatment of glioblastoma (GBM). We previously found that miR-519a functions as tumor suppressor glioma by targeting signal transducer and activator transcription 3 (STAT3)-mediated autophagy oncogenic pathway. Here, we investigated effects on TMZ chemosensitivity GBM cells. Furthermore, underlying molecular mechanisms signaling pathways were explored.In present study, two stable TMZ-resistant cell lines successfully generated...
Glioblastoma, a common malignant intracranial tumor, has the most dismal prognosis. Autophagy was reported to act as survival-promoting mechanism in gliomas by inducing epithelial-to-mesenchymal transition (EMT). Here, we determined critical molecules involved autophagy-induced EMT and elucidated possible of chemoradiotherapy resistance tumor recurrence.We used isobaric tags for relative absolute quantitation identify proteins pathway mediating via autophagy inducer treatment, tested...
Temozolomide resistance remains a major obstacle in the treatment of glioblastoma (GBM). The combination temozolomide with another agent could offer an improved option if it overcome chemoresistance and prevent side effects. Here, we determined critical drug that cause ferroptosis GBM cells elucidated possible mechanism by which overcomes chemoresistance.Haloperidol/temozolomide synergism was assessed cell lines different dopamine D2 receptor (DRD2) expression vitro vivo. Inhibitors...
Glioma proliferation is a multistep process during which sequence of genetic and epigenetic alterations randomly occur to affect the genes controlling cell proliferation, death stability. microRNAs are emerging as important modulators multiple target genes, leading abnormal cellular signaling involving in cancers.In present study, we found that expression miR-195 was markedly downregulated glioma lines human primary tissues, compared normal astrocytes matched non-tumor associated tissues....
The epithelial-to-mesenchymal (-like) transition (EMT), a crucial embryonic development program, has been linked to the regulation of glioblastoma (GBM) progression and invasion. Here, we investigated role MIR517C/miR-517c, which belongs C19MC microRNA cluster identified in our preliminary studies, pathogenesis GBM. We found that MIR517C was associated with improved prognosis patients Furthermore, following treatment autophagy inducer temozolomide (TMZ) low glucose (LG), degraded KPNA2...
Rationale: Glioblastoma (GBM) is the most common and aggressive brain tumor, characterized by its propensity to invade surrounding parenchyma. The effect of extracellular high-mobility group box 1 (HMGB1) protein on glioblastoma progression still controversial. p62 overexpressed in glioma cells, has been associated with malignant features poor prognosis GBM patients. Hence, this study aimed clarify role HMGB1-induced epithelial-mesenchymal transition (EMT) both vitro vivo. Methods:...
In recent years, the transsphenoidal approach has been extensively used surgically to treat parasellar, suprasellar, clival, and even petrous lesions. Extended pneumatization of sphenoid sinus (SS) is considered an indispensable element for extended (ETS) approach. Because most anatomical studies ETS use Caucasian subjects, present study aims clarify pneumatic extension types in Chinese individuals as well any differences from those Caucasians analyze these with respect application A total...
The growth pattern of craniopharyngiomas (CP) is yet to be understood due challenges arising from the diversity morphological features that exist. This in turn has had implications on development safe surgical strategies for management these lesions. aim this study propose a classification CP based their tumor-membrane relationship. It hoped will contribute better understanding morphology and prediction intraoperative classification.Histological techniques were used eight fetuses. Following...
OBJECT Craniopharyngiomas (CPs) are rare epithelial tumors that often associated with an enigmatic and unpredictable growth pattern. Understanding the patterns of these has a direct impact on surgical planning may enhance safety radical tumor removal. The aim this study was to analyze treatment CPs focus involvement hypothalamopituitary axis relationship arachnoid membrane surrounding structures. METHODS Clinical data from 226 consecutive patients primary CP were retrospectively reviewed....
A versatile dual-functional polydimethylsiloxane (PDMS) sponge Surface Enhanced Raman Scattering (SERS) substrate has been fabricated for the on-site detection of pesticide residues both on surface and in solution with minimum or no sample pretreatment.
Accurate anatomical matching for patient-specific electromyographic (EMG) mapping is crucial yet technically challenging in various medical disciplines. The fixed electrode construction of multielectrode arrays (MEAs) makes it nearly impossible to match an individual's unique muscle anatomy. This mismatch between the MEAs and target muscles leads missing relevant activity, highly redundant data, complicated placement optimization, inaccuracies classification algorithms. Here, we present...
Acute Stanford type A aortic dissection (ATAAD) is characterized by intimal tearing and false lumen formation containing large amounts of erythrocytes with heme. Heme oxygenase 1 (HO-1) the key enzyme to degrade heme for iron accumulation further ferroptosis. The current study aimed at investigating role HO-1 in progression ATAAD.Bioinformatic analyses experimental validation were performed reveal ferroptosis expression ATAAD. Human vascular smooth muscle cell (HA-VSMC) was used explore...
OBJECT Craniopharyngiomas are associated with a high rate of recurrence. The surgical management recurrent lesions has been among the most challenging neurosurgical procedures because craniopharyngioma's complex topographical relationship surrounding structures. aim this study was to define determinative role site origin on growth pattern and clinical features craniopharyngiomas. METHODS authors performed retrospective analysis 52 patients who had undergone uniform treatment by single...
Background: Hydrogen sulfide (H 2 S) has shown promising therapeutic benefits in reversing a variety of pathophysiological processes cardiovascular system, including myocardial ischemia–reperfusion (IR) injury. However, the achievement controlled and sustained release H S been technical bottleneck that limits clinical application gas molecule. Methods: The current study describes development mesoporous iron oxide nanoparticles (MIONs) which were loaded with diallyl trisulfide (DATS), donor...
Abstract The dissimilarity of material composition in existing stretchable electronics and biological organisms is a key bottleneck, still yet to be resolved, toward seamless integration between species. For instance, human or animal tissues skins are fully made out soft polymer species, while composed rigid inorganic materials, either purely partially. Soft polymeric materials with intrinsic softness stretchability sought after therefore proposed address this technical challenge. Here,...