A5103074038- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Healthcare Systems and Practices
- Cancer Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Trauma and Emergency Care Studies
- Chronic Disease Management Strategies
- Peripheral Artery Disease Management
- Neurological Disorders and Treatments
- Blockchain Technology Applications and Security
- Global Cancer Incidence and Screening
- Cerebral Venous Sinus Thrombosis
- Glioma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Immune Response and Inflammation
- Retinal and Optic Conditions
- Heart Failure Treatment and Management
- Glaucoma and retinal disorders
- Orthopedic Surgery and Rehabilitation
- Neutropenia and Cancer Infections
- Colorectal and Anal Carcinomas
- Intracranial Aneurysms: Treatment and Complications
- Lung Cancer Diagnosis and Treatment
Cooper Medical School of Rowan University
2020-2025
Cooper University Hospital
2023-2024
B.J. Medical College
2024
New York University
2022-2023
University of Arkansas for Medical Sciences
2023
Johns Hopkins Medicine
2021-2022
Johns Hopkins University
2018-2022
Icahn School of Medicine at Mount Sinai
2019-2022
Meenakshi Medical College Hospital and Research Institute
2022
Stony Brook University
2022
Chronic immune activation is a major complication of antiretroviral therapy (ART) for HIV infection and can cause devastating reconstitution inflammatory syndrome (IRIS) in the brain. The mechanism T-cell this population not well understood. We found HIV-Tat protein IL-17–expressing mononuclear cells brain an individual with IRIS. Tat was also present CSF individuals virologically controlled on ART. Hence we examined if could directly activate T cells. transcriptionally dysregulated 94 genes...
Patients with glioblastoma die from local relapse despite surgery and high-dose radiotherapy. Resistance to radiotherapy is thought be due efficient DNA double-strand break (DSB) repair in stem-like cells able survive damage repopulate the tumor. We used clinical samples patient-derived stem (GSCs) confirm that DSB protein RAD51 highly expressed GSCs, which are reliant on RAD51-dependent after radiation. expression foci numbers fall when these move toward astrocytic differentiation. In...
Introduction: Thrombolytic therapy has been a standard part of treatment large vessel occlusion acute ischemic strokes. There is, however, insufficient evidence in literature to draw significant conclusions as the efficacy different thrombolytic agents with extremes age (elderly or young) minor stroke patients. The objective is describe rates clinical improvement patients various across ages. Methods: A registry between 1/2017 - 9/2023 was retrospectively reviewed. Patients National...
Introduction: First pass effect (FPE) in endovascular thrombectomy (EVT) is associated with favorable treatment course and recovery, making it an important prognostic indicator for patients undergoing EVT. Atrial fibrillation (AF) related strokes have been shown to be greater rates of FPE acute large vessel occlusions; however, the association between AF medium occlusions (MeVO) unknown. We aimed assess achieving MeVO. Methods: A prospectively-maintained retrospective registry adult ischemic...
Background First-pass effect (FPE) in endovascular thrombectomy (EVT) is strongly associated with clinically favorable outcomes. Atrial fibrillation (AF)-related strokes have been shown to be greater rates of FPE acute large vessel occlusions (LVOs). In this study, we aimed assess the association between AF and achieving medium (MeVOs). Methods A prospectively maintained registry adult ischemic stroke patients at a comprehensive center October 2019 2023 was retrospectively screened for...
Abstract Background The etiology and immunopathology of multiple sclerosis (MS) is not well understood. It recognized that although autoreactive T cells are the main early mediators disease, other cell types, including innate immune system contribute to MS pathogenesis. objective this study was determine if Toll-like receptor (TLR) signaling functionally altered in patients with MS. Findings Peripheral blood mononuclear from healthy donors relapsing remitting were stimulated specific...
Background In large vessel occlusion (LVO) stroke patients transferred to a comprehensive center for thrombectomy, spontaneous reperfusion may occur during transport, and anecdotally more frequently in via helicopter than by ground. This pattern has been often observed conjunction with tenecteplase (TNK) treatment prior transport. We aim explore the “chopperlysis” effect—how particularly thrombolytics, affect clinical outcomes. Methods A single thrombectomy capable (TCC) registry of was...
Introduction The emergence and rapid spread of the coronavirus disease 2019 (COVID-19) pandemic have revealed limitations in current healthcare systems to handle patient records securely transparently, novel protocols are required address these shortcomings. An attractive option is use Ethereum smart contracts secure storage medical concomitant data logs. an open-source platform that can be used construct contracts, which collections code allow transactions under certain parameters...
Introduction Hyper-cytokinemia is a dreaded complication of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection and an important predictor mortality in disease 2019 (COVID-19). The current evidence at best still ambiguous for use tocilizumab cytokine storm COVID-19. Moreover, the factors that are associated with beneficial response from unknown We aimed to study clinical outcomes especially vis-à-vis laboratory characteristics patients administered identify predictors...
BACKGROUND: Thrombectomy for basilar artery occlusion (BAO) has proven efficacy in patients with moderate-to-severe deficits, but unclear benefits those mild symptoms. METHODS: Using an observational cohort design, the US National Inpatient Sample (2018–2020) was queried adult and Institutes of Health Stroke Scale (NIHSS) <10 treated thrombectomy versus medical management. The primary outcome routine discharge (to home or self-care) evaluated using multivariable logistic regression...
Background Prior studies have shown benefit for endovascular therapy (EVT) in patients with large‐vessel occlusion and severe deficits, as captured by the National Institutes of Health Stroke Scale (NIHSS). However, EVT NIHSS score <6 is unclear. Methods We queried Inpatient Sample (2018–2020) a internal carotid or middle cerebral artery an <6, compared outcomes between treated versus best medical management, using propensity matching. The primary outcome was routine discharge (home...
Introduction: Tenecteplase (TNK) is increasingly being utilized for IV thrombolysis in acute ischemic stroke, including patients with large vessel occlusion (LVO) prior to transfer an endovascular thrombectomy (EVT) capable center (TCC). However, there limited data regarding factors that influence functional outcome between the time of TNK administration and TCC arrival. The purpose this analysis characterize effect arrival method on effectiveness improve patient outcomes. Methods: A...