A5039747154- Inhalation and Respiratory Drug Delivery
- Medical Imaging Techniques and Applications
- Refrigeration and Air Conditioning Technologies
- Radiomics and Machine Learning in Medical Imaging
- Air Quality Monitoring and Forecasting
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Atomic and Subatomic Physics Research
- Hemodynamic Monitoring and Therapy
- Advanced X-ray and CT Imaging
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
- Heat Transfer and Optimization
- Cardiac Imaging and Diagnostics
- Pediatric Urology and Nephrology Studies
- Aerosol Filtration and Electrostatic Precipitation
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiation Dose and Imaging
- Phase Equilibria and Thermodynamics
- Radiopharmaceutical Chemistry and Applications
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Function and Risk Factors
- Radioactive Decay and Measurement Techniques
- Medical Imaging and Pathology Studies
National Institute of Environmental Health Sciences
2025
University Hospital Southampton NHS Foundation Trust
2010-2024
NIHR Biomedical Research Centre at The Royal Marsden and the ICR
2023-2024
National Institute for Health Research
2024
NIHR Southampton Respiratory Biomedical Research Unit
2011-2016
Air Liquide (France)
2015
University of Southampton
1977-2014
British Nuclear Medicine Society
2004-2014
Weatherford College
2014
University of Rochester
2013
These guidelines have been adopted by the British Nuclear Medicine Society.
Anagrelide is a member of the imidazo (2,1-b) quinazolin-2-one series compounds, with powerful antiaggregating effect on platelets. During studies in humans, anagrelide small doses has produced thrombocytopenia. We therefore evaluated it treatment thrombocytosis, and to date, platelet levels 15 17 patients primary thrombocythemia, 2 polycythemia vera 1 patient chronic granulocytic leukemia thrombocytosis have been well controlled use this agent. Induction 1.0 1.5 mg given orally every six...
Describes a general method for the measurement of radioactivity in an organ using anterior, posterior and lateral views. Its application to liver colloid imaging is described as liver/spleen ratio widely used indication cirrhosis.
A technique is described for using computed tomography (CT) images attenuation correction and quantification in SPECT. The CT are aligned with the corresponding SPECT slices Hounsfield units converted to linear coefficient values radionuclide. map thus produced used provide required reconstruction. has been evaluated both a non-anatomical an anatomical phantom giving mean accuracy quantifying activity of various features phantoms 2.6% (range 0.3%-4.0%). value performing scatter prior...
A novel gamma-ray camera is proposed that based on the Compton effect. The basis of device a segmented semiconductor detector which able to locate successive interaction points in multicollision trajectories and associated energy losses. In this way, conic section can be computed an image plane for each emission from point source object. An overall constructed by summation individual ellipses. effect measurement errors investigated theoretically simulation, leads favourable estimates...
Two-dimensional (2D or planar) imaging with (99m)Tc radiolabels enables quantification of whole-lung and regional lung depositions for orally inhaled drug products. This article recommends standardized methodology 2D studies. Simultaneous anterior posterior a dual-headed gamma camera is preferred, but single-headed also acceptable. Correction raw data the effects ray attenuation considered essential accurate quantification, instance, using transmission scanning flood-field source (57)Co....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural Studies by Nuclear Magnetic Resonance. II. Aldehyde 2,4-DinitrophenylhydrazonesGerasimos J. Karabatsos, Bernard L. Shapiro, Floie M. Vane, John S. Fleming, and Jane RatkaCite this: Am. Chem. Soc. 1963, 85, 18, 2784–2788Publication Date (Print):September 1, 1963Publication History Published online1 May 2002Published inissue 1 September 1963https://pubs.acs.org/doi/10.1021/ja00901a025https://doi.org/10.1021/ja00901a025research-articleACS...
Regional cerebral blood flow, volume, fractional oxygen extraction and consumption were measured by positron emission tomography in six patients with sickle cell disease to see how delivery the brain is maintained presence of both anemia a low affinity hemoglobin. Both regional flow volume found be markedly increased compared values obtained from 14 normal subjects same age range. The mean was not significantly different two groups. Mean groups also but individual atrophy on CT-scans three...
A scintillation camera with digital data store has been used to assess renal function. Analysis of the renogram by deconvolution, using an on-line computer, shows promise as a means expressing function in terms tubular transit times for 123I-Hippuran.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA nuclear magnetic resonance study of .sigma.-cyclopentadienyl(triethylphosphine)copper(I)George M. Whitesides and John S. FlemingCite this: J. Am. Chem. Soc. 1967, 89, 12, 2855–2859Publication Date (Print):June 1, 1967Publication History Published online1 May 2002Published inissue 1 June 1967https://pubs.acs.org/doi/10.1021/ja00988a011https://doi.org/10.1021/ja00988a011research-articleACS PublicationsRequest reuse permissionsArticle...
Abstract Clinical research on the deposition of inhaled substances (e.g. medications, airborne contaminants, fumes) in lungs necessitates anatomical models airways. Current conducting airway lack three‐dimensional (3D) reality as little information is available literature distribution airways space. This a limitation to assessment or predictions particle relation subject’s anatomy. Detailed full topology and morphology thus required model tree realistically. paper presents length, diameter,...
Summary Conventional creatinine clearances involving urine collections over 2, 4 and 24 hours clearance predicted from plasma concentrations without collection were compared to glomerular filtration rate (GFR) estimated by 99mTc DTPA in 171 patients with a wide range of GFR. All methods had standard errors the estimate GFR greater than predictions formulae. Predictions formulae coefficients variation approximately 23% when isotopically determined Creatinine these equations stable renal...
Abstract Aerosols of nedocromil sodium labelled with 99Tcm were delivered on 20 separate occasions to healthy male volunteers. Planar and single photon emission computerized tomography (SPECT) gamma scintigraphy immediately performed assess the pulmonary regional distribution aerosol. On a occasion volunteers imaged using X-ray computed (CT). Alignment SPECT CT images was marked anatomical features anterior lateral skin outlines. provided data for attenuation correction used define lung...
1. Simultaneous radioisotopic (99Tc-DTPA) gastric emptying measurements and paracetamol pharmacokinetic studies were performed in eight healthy male volunteers with without levodopa (125 mg orally). 2. In the absence of gamma camera imaging showed rapid mono or biexponential all subjects plasma concentration-time curves for displayed a single major peak. 3. presence time to 90% was prolonged from 32 +/- 24 min 81 20 (P less than 0.01). Gastric interrupted by plateau phase six this pattern...