A5079918879- Mast cells and histamine
- Food Allergy and Anaphylaxis Research
- Renin-Angiotensin System Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal Diseases and Glomerulopathies
- Drug-Induced Adverse Reactions
- Sexual function and dysfunction studies
- Amino Acid Enzymes and Metabolism
- Pneumocystis jirovecii pneumonia detection and treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cellular transport and secretion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Urticaria and Related Conditions
RELX Group (United States)
2020
Centre de Recherche sur l'Inflammation
2017-2019
Inserm
2013-2019
Université Paris Cité
2013-2019
Sorbonne Paris Cité
2013-2019
Centre National de la Recherche Scientifique
2014-2019
Délégation Paris 7
2013-2017
Abstract Mast cell degranulation requires N-ethylmaleimide–sensitive factor attachment protein receptors (SNARE) and mammalian uncoordinated18 (Munc18) fusion accessory proteins for membrane fusion. However, it is still unknown how their interaction supports In this study, we found that small interfering RNA–mediated silencing of the isoform Munc18-2 in mast cells inhibits cytoplasmic secretory granule (SG) release but not CCL2 chemokine secretion. Silencing its SNARE-binding partner...
Abstract Ischemia–reperfusion injury (IRI) is an important cause of acute kidney that can lead to end-stage renal failure. Although the ensuing inflammatory response restore homeostasis, a consecutive maladaptive repair and persistent inflammation represent risk factors for postischemic chronic disease development. In this study, we investigated role mast cells in both early late phases experimental models IRI using our recently developed mouse model allows conditional ablation cells....
Obstructive nephropathy constitutes a major cause of pediatric renal progressive disease. The mechanisms leading to disease progression are still poorly understood. Kidney fibrotic lesions reproduced using model partial unilateral ureteral obstruction (pUUO) in newborn mice. Based on data showing significant mast cell (MC) infiltration patients, we investigated the role MC and murine MCPT4, MC-released chymase, pUUO MC- (Wsh/sh), MCPT4-deficient (Mcpt4-/-), wild-type (WT) Measurement kidney...