A5022228695- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Cerebrospinal fluid and hydrocephalus
- Musculoskeletal pain and rehabilitation
- Glioma Diagnosis and Treatment
- Spinal Hematomas and Complications
- Vascular Malformations Diagnosis and Treatment
- Epilepsy research and treatment
- Social Media in Health Education
- Cerebral Venous Sinus Thrombosis
- Osteoarthritis Treatment and Mechanisms
- Innovations in Medical Education
- Intracranial Aneurysms: Treatment and Complications
- Teratomas and Epidermoid Cysts
- Antifungal resistance and susceptibility
- Venous Thromboembolism Diagnosis and Management
- Pain Mechanisms and Treatments
- Neurosurgical Procedures and Complications
- Ethics in medical practice
- Pharmacological Effects and Toxicity Studies
- Surgical site infection prevention
- Ethics in Clinical Research
- Meningioma and schwannoma management
- Scoliosis diagnosis and treatment
King Abdulaziz University
2014-2025
McGill University
2015-2025
Shriners Hospitals for Children - Canada
2025
Deleted Institution
2023
Montreal Neurological Institute and Hospital
2018-2022
McGill University Health Centre
2017-2022
Montreal General Hospital
2022
Jewish General Hospital
2016-2018
King Abdulaziz Hospital
2014
Mayo Clinic in Arizona
1989
Tryptase, a neutral protease of human mast cells, is potentially important indicator cell involvement in various clinical conditions. The current study examined the time course appearance and disappearance tryptase circulation after an anaphylactic event stability both endogenous exogenous terms freeze-thawing temperature. peak level experimentally induced systemic reaction occurred 1-2 h initiating bee sting each three subjects, contrast to histamine levels which peaked at 5-10 min. In some...
The cartilaginous endplates (CEPs) are thin layers of hyaline cartilage found adjacent to intervertebral discs (IVDs). In addition providing structural support, CEPs regulate nutrient and metabolic exchange in the disc. IVD pathogenesis, CEP undergoes degeneration calcification, compromising availability disc cell metabolism. mechanism(s) underlying biochemical changes currently unknown. Since calcification is often observed later stages degeneration, we hypothesised that elevations free...
Abstract Surgical site infections (SSIs) are common complications after spinal surgery that result in increased morbidity, mortality, and healthcare costs. It was estimated SSIs resulted a 4-fold increase health care The reported SSI rate following remains highly variable between approximately 0.5% 18%. In this study, we aimed to estimate the identify possible risk factors for our Saudi patient population. We conducted single-center, retrospective case–control study Arabia included patients...
Abstract Children with Christianson syndrome (CS), an X-linked neurodevelopmental disorder caused by loss-of-function mutations in the alkali cation/proton exchanger SLC9A6/NHE6, display severe cognitive impairments, mutism, and sensory abnormalities such as hyposensitivity to pain. However, it is unclear whether these children other their pain result of elevated threshold or a complete insensitivity To better characterize this disorder, we used combination mouse model CS questionnaires...
Pain in lower back is a common condition reported by astronauts, both during and after space missions. Investigating the alterations spine mechanisms driving these changes essential for deeper understanding of how microgravity impacts human spine. This knowledge could also open pathways therapeutic or preventive interventions. Nevertheless, there limited evidence regarding intervertebral discs (IVDs) due to travel. In this study, 2 astronauts were enrolled Before flight, magnetic resonance...
Invasive sinonasal aspergillosis is a silently progressive disease that, left untreated, may invade the adjacent intracranial and intra-orbital compartments incurring serious morbidity.To evaluate our results of collaborative surgical management plans for patients with invasive orbitocranial extension.Retrospective study.Between years 2000 2012, 12 Aspergillus sinusitis extension were treated at institution. Preoperative CT MRI scans done in all cases cerebral angiography two subarachnoid...
This study aims to glean patient and caregiver perspectives surrounding deep brain stimulation (DBS) in children youth through an analysis of patterns social media usage.The authors performed a comprehensive search the Twitter Application Programming Interface (API) database for all tweets about DBS use youth, with no date restriction. Data pertaining each tweet were extracted analysis. Results analyzed using qualitative quantitative methodologies. These included thematic tweets, accounts,...
Link N (DHLSDNYTLDHDRAIH) is a peptide that occurs naturally in the intervertebral discs (IVDs) and cartilage as result of proteolytic cleavage protein. Several studies have identified growth factor capable stimulating matrix synthesis these tissues. We recently discovered annulus fibrosus cells can release an enzyme (possibly cathepsin K) further cleave resulting eight amino acid peptide, we called short (sLink N). Separately, developed validated organ culture model has vertebrae attached...
Primary central nervous lymphoma (PCNSL) is a rare variant of extranodal non-Hodgkin's with especially poor prognosis. The diagnosis usually encountered in immunodeficient patients but also encountered, albeit uncommonly, the immunocompetent. We present 50-year-old male who developed signs and symptoms increased intracranial pressure. Imaging revealed presence fourth ventricle mass obstructive hydrocephalus. First, patient underwent emergency endoscopic third ventriculostomy followed, few...
Myelopathy at the level of atlas is rarely encountered by practicing spine surgeon. Due to region's unique anatomy, compression cord this either caused a large compressing lesion or an abnormally stenotic canal. We describe rare instance congenitally canal due hypoplastic intact posterior arch atlas, coexisting with extremely ossified transverse ligament atlas. The coexistence these two lesions has only been documented thrice before. clinical presentation, imaging findings, and favorable...
Degenerative cervical myelopathy (DCM) is a progressive neurologic condition caused by age-related degeneration of the spine. Social media has become crucial part many patients' lives; however, little known about social use pertaining to DCM.This manuscript describes landscape and DCM in patients, caretakers, clinicians, researchers.A comprehensive search entire Twitter application programing interface database from inception March 2022 was performed identify all tweets myelopathy. Data on...
Abstract Background Unilateral laminotomy with bilateral spinal canal decompression has gained popularity recently. Aim To systematically review the literature of unilateral for lumbar stenosis (LSS) aiming to assess outcomes and complications different techniques described in literature. Methods On August 7, 2022, Pubmed EMBASE were searched by 2 reviewers independently, all relevant studies published up date considered based on predetermined inclusion exclusion criteria. The subject...
Abstract Background Extracellular vesicles (EVs) function as biomarkers and are crucial in cell communication regulation, with therapeutic potential for intervertebral disc (IVD)‐related low back pain (LBP). EV cargo is often affected by tissue health, which may affect the potential. There currently limited knowledge of how IVD cell‐derived EVs varies health differences proteomic profile predicted biological functions. Methods Our study purified from human conditioned media size‐exclusion...
The quality of healthcare outcomes and patient satisfaction are affected by communication skills professionalism the physician. Medical curricula have substantial influence on physicians' perception professionalism.The aim this study was to determine impact medical curriculum values residents at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, their opinions identify sources that they describe as most influential in shaping views.This cross sectional conducted 2010/2011. A modified...
Objective: The study objective was to investigate patients' attitudes toward clinical trial participation and the barriers participation. We also aimed estimate proportion of patients willing participate in trials.Methods: conducted a survey on who were scheduled have minor or major surgery at King Abdulaziz University Hospital between May 2018 December 2018. used questionnaire that comprised 27 multiple-choice questions assess knowledge Data analyzed using Statistical Package for Social...
Cerebellar hemorrhage remote from the operative site is an unpredictable and rare complication in neurosurgery, with reported rates of morbidity mortality literature 8.4% 7.8%, respectively. The range procedures associated cerebellar diverse includes both supratentorial spinal that entail significant cerebral fluid loss or resection content. We present here first documented case after controlled drainage by ventriculoperitoneal shunt, discuss proposed pathophysiology treatment. a...