A5100705928- Autophagy in Disease and Therapy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advanced ceramic materials synthesis
- Heme Oxygenase-1 and Carbon Monoxide
- Liver Disease and Transplantation
- RNA Interference and Gene Delivery
- Polyamine Metabolism and Applications
- Fatty Acid Research and Health
- Parasitic Infections and Diagnostics
- Endoplasmic Reticulum Stress and Disease
- Advanced materials and composites
- RNA modifications and cancer
- Herpesvirus Infections and Treatments
- Bioactive Compounds and Antitumor Agents
- Silymarin and Mushroom Poisoning
- Liver Disease Diagnosis and Treatment
- Veterinary Oncology Research
- Speech Recognition and Synthesis
- interferon and immune responses
- Bioactive Natural Diterpenoids Research
- Enzyme Production and Characterization
- Agriculture, Soil, Plant Science
- Coccidia and coccidiosis research
- Digital Radiography and Breast Imaging
- Genomics, phytochemicals, and oxidative stress
Korea University
2024
Yale University
2017-2024
Yeungnam University
2023
Pusan National University
2011-2022
Electronics and Telecommunications Research Institute
2002-2022
Korea Institute of Ceramic Engineering and Technology
2012-2022
Pulmonary and Critical Care Associates
2022
SleepMed
2022
University of Mississippi Medical Center
2020
Kangbuk Samsung Hospital
2020
Recently, the interplay between autophagy and apoptosis has become an important factor in chemotherapy for cancer treatment. Inhibition of may be effective strategy to improve treatment chemo-resistant by consistent exposure chemotherapeutic drugs. However, no reports have clearly elucidated underlying mechanisms. Therefore, this study, we assessed whether salinomycin, a promising anticancer drug, induces potential antitumor mechanisms prostate cells. Cell viability assay, Western blot,...
// Sang-Hun Kim 1, 2 , Kwang-Youn 3 Sul-Gi Park 1 Sun-Nyoung Yu Young-Wook Hyo-Won Nam Hyun-Hee An Young-Woo 4 and Soon-Cheol Ahn 5 Department of Microbiology & Immunology, Pusan National University School Medicine, Yangsan 50612, Republic Korea Section Pulmonary, Critical Care Sleep Internal Yale New Haven, Connecticut 06510, USA Korean Medicine Application Center, Institute Oriental Daegu 41062, Herbal Formula, Medical Research Center (MRC-GHF), College Haany University, Gyeongsan...
Monensin is a carboxyl polyether ionophore that potently inhibits the growth of various cancer cells. Recently, anticancer effects monensin have been recognized based on its ability to induce apoptosis in However, effect and mechanism action yet be investigated, especially against human prostate cells.Cell viability assay, western blot, cell-cycle arrest, annexin V/propidium iodide reactive oxygen species (ROS) production intracellular Ca2+ flux were assayed.In this study, significantly...
Tissue repair requires a highly coordinated cellular response to injury. In the lung, alveolar type 2 cells (AT2s) act as stem replenish both themselves and 1 (AT1s); however, complex orchestration of cell activity after injury is poorly understood. Here, we establish longitudinal imaging AT2s in murine intact tissues ex vivo order track their dynamic behavior over time. We discover that large fraction become motile following provide direct evidence for migration between units....
The limited treatment option for recurrent prostate cancer and the eventual resistance to conventional chemotherapy drugs has fueled continued interest in finding new anti-neoplastic agents of natural product origin. We previously reported anti-proliferative activity deoxypodophyllotoxin (DPT) on human cells. Using PC-3 cell model cancer, present study reveals that DPT induced apoptosis via a caspase-3-dependent pathway is activated due dysregulated mitochondrial function. DPT-treated cells...
Salinomycin is a monocarboxylic polyether antibiotic, which widely used as an anticoccidial agent. The anticancer property of salinomycin has been recognized and based on its ability to induce apoptosis in human multidrug resistance (MDR). present study investigated whether reverses MDR towards chemotherapeutic agents doxorubicin‑resistant MCF‑7/MDR breast cancer cells. results demonstrated that doxorubicin‑mediated cytotoxicity was significantly enhanced by the cells, this occurred...
Silibinin, a biologically active compound of milk thistle, has chemopreventive effects on cancer cell lines. Recently it was reported that silibinin inhibited tumor growth through activation the apoptotic signaling pathway. Although various evidences showed multiple pathways in apoptosis, there were no reports to address clear mechanism ROS-mediated pathway prostate PC-3 cells. Several studies suggested reactive oxygen species (ROS) play an important role cascades, but primary source ROS...
Background/Aim: Chemotherapy is a critical option for cancer treatment. However, consistent exposure to chemotherapeutic drugs promotes chemoresistance in cells through diverse mechanisms. Accordingly, we investigated whether salinomycin, monocarboxylic ionophore, could induce apoptosis aggressive breast or not, as well its underlying mechanism. Materials and Methods: Using salinomycin on two cell lines, MCF-7 MDA-MB-231 cells, viability, annexin V/propidium iodide staining, acridine orange...
Chronic obstructive pulmonary disease (COPD) is characterized by chronic injury and oxidative stress leading to progressive lung tissue destruction. Emerging evidence suggests that regulated cell death pathways, particularly ferroptosis, contribute COPD pathology. We previously identified the response protein known ferroptosis inhibitor nuclear 1 (NUPR1) as markedly downregulated in from patients. Here, we demonstrate NUPR1 inhibition exacerbates iron accumulation, enhances lipid...
Influenza viruses can result in significant lung injury with morbidity and mortality. In this study, we evaluated the impact of cigarette smoke (CS) exposure on pulmonary fibroblastic response after influenza infection. We used a murine model which animals were exposed to CS or room air subsequently infected H1N1 virus. Inflammatory fibrotic responses measured at different time points Primary fibroblasts isolated from lungs mice their characteristics evaluated. Exposure significantly...
Idiopathic pulmonary fibrosis (IPF) is a chronic lung condition characterized by the abnormal regulation of extracellular matrix (ECM) and epithelial-mesenchymal transition (EMT). In this study, we investigated potential rutin, natural flavonoid, in attenuating transforming growth factor-β (TGF-β)-induced ECM EMT through inhibition TGF-β type I receptor (TβRI)-mediated suppressor mothers against decapentaplegic (SMAD) signaling pathway. We found that non-toxic concentrations rutin attenuated...
Abstract Intracellular infiltration of bacteria into host cells complicates medical and surgical treatment bacterial joint infections. Unlike soft tissue infections, septic arthritis infection‐associated inflammation destroy cartilage that does not regenerate once damaged. Herein, we show glycolytic pathways are shared by methicillin‐resistant Staphylococcus aureus (MRSA) proliferation inflammatory machinery in arthritis. MRSA readily penetrates induces proinflammatory cascades persist after...
Encephalitozoon cuniculi is a microsporidian parasite commonly found in rabbits that can infect humans, causing encephalitozoonosis. The prevalence of encephalitozoonosis not well documented, even when many clinics suspect pet as being highly infected. This study investigated the seropositivity E. using ELISA. examination 186 ELISA showed 22.6% (42/186) were seropositive against cuniculi. In analysis with healthy status, all 42 sera collected from clinically normal rabbits. Moreover, gender...