A5080586067- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Bariatric Surgery and Outcomes
- Diabetes Treatment and Management
- Diabetes Management and Research
- Nutrition and Health Studies
- Diabetes and associated disorders
- Body Contouring and Surgery
- Gestational Diabetes Research and Management
- Innovations in Medical Education
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition, Genetics, and Disease
- Clinical Reasoning and Diagnostic Skills
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diet and metabolism studies
- Medical Education and Admissions
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Diabetes Management and Education
- Intellectual Property Rights and Media
- Obesity and Health Practices
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
- Genetic Associations and Epidemiology
- Gut microbiota and health
Jagiellonian University
2016-2025
Krakow Cardiovascular Research Institute
2011-2024
Cracow University of Technology
2024
Szpital Uniwersytecki w Krakowie
2019
Addenbrooke's Hospital
2010
Gastrointestinal tract microbiota, particularly bacterial microflora, seem to have a different qualitative and quantitative composition in both type 1 (T1DM) 2 diabetes (T2DM) mellitus cases as compared non-diabetic individuals. So far, there are no data from research concerning the prevalence of fungi, most common genus, i.e. Candida, which important components human colon microflora. We aimed examine whether changes Candida fungi feces patients with T1DM T2DM healthy controls.Overall, we...
Clinical reasoning entails the application of knowledge and skills to collect integrate information, typically with goal arriving at a diagnosis management plan based on patient's unique circumstances preferences. Evidence-informed, structured, explicit teaching assessment clinical in educational programs medical other health professions remain unmet needs. We herein summarize recommendations for learning objectives (LOs), as derived from consensus approach among European US researchers...
The studies on microbiome in the human digestive tract indicate that fungi could also be one of external factors affecting development diabetes. aim this study was to evaluate quantitative and qualitative mycobiome composition colon adults with type 1 (T1D), n = 26 2 (T2D) diabetes, 24 compared control group, 26. gut characterized stool samples using analysis whole internal transcribed spacer (ITS) region fungal rDNA gene cluster by next-generation sequencing (NGS) increased sensitivity. At...
SGLT2 inhibitors are a new class of oral hypoglycemic agents used in type 2 diabetes (T2DM). Their effectiveness maturity onset the young (MODY) is unknown. We aimed to assess response single dose 10 mg dapagliflozin patients with Hepatocyte Nuclear Factor 1 Alpha (HNF1A)-MODY, Glucokinase (GCK)-MODY, and diabetes. examined 14 HNF1A-MODY, 19 GCK-MODY, 12 patients. All studied individuals received morning added their current therapy To we analyzed change urinary glucose creatinine ratio serum...
The expansion of medical schools is one the proposed solutions to shortages in health workforces. Poland has been struggling with limited human resources healthcare for years. aim study was provide an analysis current situation education and describe impact government's ongoing measures a new influx doctors. A retrospective, cross-sectional presents descriptive comparative official governmental documents, showing latest legal amendments, changes admission limits, geographical distribution...
Little is known about the impact of sleep duration and late-night snacking on glycemic control in patients with type 1 diabetes using insulin pumps. The aim present study was to examine whether eating habits short are associated continuous subcutaneous infusion-treated diabetic patients.We included 148 consecutive adult subjects an pump (100 women 48 men). Participants completed a questionnaire regarding (classified as if ≤6 h) snacking. Other sources information medical records data from...
To investigate the utility of biomarkers maturity-onset diabetes young (MODY), high-sensitivity C-reactive protein (hsCRP), and 1,5-anhydroglucitol (1,5-AG) in conjunction with other clinical laboratory features to improve diagnostic accuracy provide a algorithm for HNF1A MODY.We examined 77 patients MODY, 88 GCK MODY mutations, 99 type 1 diabetes, 92 2 diabetes. In addition 1,5-AG hsCRP, we considered body mass index (BMI), fasting glucose, serum C-peptide as potential biomarkers. Logistic...
Available clinical data on the influence of baseline HbA1c postoperative morbidity and readmission after laparoscopic sleeve gastrectomy is scarce. This prompted us to conduct a multicenter retrospective study evaluating chronic hyperglycemia course among patients undergoing (SG). We aimed investigate levels outcomes in SG. conducted cohort consecutive who underwent SG from March 2017 2018 seven referral centers for bariatric surgery. Exclusion criteria were revision surgeries, different...
Objective Mutations in the glucokinase ( GCK ) gene, along with hepatocyte nuclear factor 1A HNF1A gene mutations, are most frequent cause of maturity-onset diabetes young (MODY). GCK-MODY patients typically characterized by a moderate fasting hyperglycemia; however, little is known about atherosclerosis and intermediate-related phenotypes these subjects. Design To examine carotid artery intima-media thickness (IMT) endothelial function assessed brachial flow-mediated dilatation (FMD)...
Mutations in the glucokinase ( GCK) gene result maturity-onset diabetes of young (MODY). Pharmacotherapy is not effective GCK MODY. Thus, nutritional intervention seems to be only therapeutic option. This study evaluated effect quantity dietary carbohydrate on glucose levels 10 mutation carriers: seven with MODY and three prediabetes. All patients were exposed high-carbohydrate diets for 2 days then switched low-carbohydrate (60% versus 25% daily calorie intake) another days, after a 1-day...
Few investigations have been conducted that compared blood glucose in patients with diabetes mellitus (DM2) and morbid obesity who had undergone laparoscopic sleeve gastrectomy (LSG) or gastric bypass (LRYGB). We aimed to compare the effects of these procedures using continuous monitoring (CGM). prospectively studied qualified for LSG LRYGB. The inclusion criteria were DM2 ≤ 5 years, which taking oral anti-diabetic drugs, no metabolism disorder; obesity. CGM was performed between admission...
This study describes a 10-year follow-up of large international multicenter cohort patients with KCNJ11 permanent neonatal diabetes. It addresses key questions relating to long-term efficacy and safety sulfonylureas in these patients.
Perioperative care and follow-up after bariatric surgery (BS) engage various medical professionals. It is key for them to be well informed about these procedures. However, knowledge attitudes may not satisfactory enough provide proper care. We aimed assess perceptions of BS among diabetologists internists. A total 34 30 internists completed the electronic questionnaire. There were no differences in self-estimated between them, except regarding items related treatment diabetes metabolic...
Abstract Aim The impact of maturity onset diabetes the young (MODY) on quality life (QoL) has never been examined. We assessed disease QoL among patients with HNF1A-MODY and GCK mutation carrier status. Methods study included 80 89 gene carriers. also examined 128 type 1 (T1DM) for comparison. Diabetes-specific was using Audit Diabetes Dependent Quality Life questionnaire. Results GCK-MODY groups had similar mean age (41.7 vs. 38.0 years, respectively) BMI (24.1 24.3 kg/m 2 ), whereas T1DM...
We aimed to assess the impact of change 1-hour postprandial glycemic target from < 6.7 mmol/L (120 mg/dL) 7.8 (140 on gestational diabetes mellitus (GDM) treatment and pregnancy outcomes.
Maturity-onset diabetes of the young (MODY) accounts for 1-2% all cases. Unfortunately, circa 90% MODY cases are misdiagnosed as type 1 or 2 diabetes. A proper genetic diagnosis based on automatic sequencing is crucial use a tailored treatment. However, this method still expensive and, thus, patients' selection testing should be performed precisely. In 2012, an easy-to-use tool was developed in Exeter, UK, to support British population. The aim study assess utility Probability Calculator...
Bariatric surgery has proven to be the most efficient treatment for obesity and type 2 diabetes mellitus (T2DM). Despite detailed qualification, desirable outcome after an intervention is not achieved by every patient. Various risk prediction models of remission metabolic have been established facilitate decision-making process. The purpose study validate performance available scores a year surgical determine optimal model.A retrospective analysis comprised 252 patients who underwent...
The most common form of maturity-onset diabetes the young (MODY) is caused by mutations in hepatocyte nuclear factor 1A (HNF1A) gene. However, HNF1A mutation-carriers are initially misdiagnosed with type 1 (T1DM) or 2 (T2DM) mellitus; hence, they often receive nonoptimal treatment. aim our study was to test newly proposed clinical criteria for identification MODY patients a diagnosis T1DM T2DM. To achieve this, following preselect screening were used: T1DM: TDIR (total daily insulin...