A5102860871- Pharmaceutical and Antibiotic Environmental Impacts
- Plant Disease Resistance and Genetics
- Plant Disease Management Techniques
- Plant Virus Research Studies
- Wastewater Treatment and Nitrogen Removal
- Digital Imaging for Blood Diseases
- Water Treatment and Disinfection
- Plant Pathogens and Fungal Diseases
- Melanoma and MAPK Pathways
- Biochemical and Molecular Research
- Epigenetics and DNA Methylation
- Polyamine Metabolism and Applications
- Insect-Plant Interactions and Control
- Constructed Wetlands for Wastewater Treatment
- Plant Physiology and Cultivation Studies
- Berry genetics and cultivation research
- Steroid Chemistry and Biochemistry
- DNA Repair Mechanisms
- Genomics, phytochemicals, and oxidative stress
- CRISPR and Genetic Engineering
- Hippo pathway signaling and YAP/TAZ
- Receptor Mechanisms and Signaling
- Pancreatic function and diabetes
- Parasitic Infections and Diagnostics
- Leaf Properties and Growth Measurement
Federal Institute of Hydrology
2018-2022
Pratt Institute
2022
Duke University
2022
Wake Forest University
2018-2022
Atrium Health Wake Forest Baptist
2018-2021
Friedrich-Alexander-Universität Erlangen-Nürnberg
2021
Freie Universität Berlin
2021
Luxembourg Institute of Science and Technology
2021
Flemish Institute for Technological Research
2021
Fraunhofer Institute for Ceramic Technologies and Systems
2021
In an earlier study for identifying quantitative trait loci (QTLs) a maize ( Zea mays L.) population generated from the cross B73 × Mo17, major effect on grain yield and related traits was detected chromosome 5. This chromosomal region has also shown significant associations with in several other studies. These findings have, thus, provided impetus to further characterize this segment. A set of BC 2 S 1 lines created, each containing intrugressed segment Mo17 background. reciprocal lines,...
Polyamine inhibition for cancer therapy is, conceptually, an attractive approach but has yet to meet success in the clinical setting. The aryl hydrocarbon receptor (AHR) is central transcriptional regulator of xenobiotic response. Our study revealed that AHR also positively regulates intracellular polyamine production via direct activation 2 genes, ODC1 and AZIN1, which are involved biosynthesis control, respectively. In patients with multiple myeloma (MM), levels were inversely correlated...
Nanoparticles occur in various environments as a consequence of man-made processes, which raises concerns about their impact on the environment and human health. To allow for proper risk assessment, precise statistically relevant analysis particle characteristics (such size, shape, composition) is required that would greatly benefit from automated image procedures. While deep learning shows impressive results object detection tasks, its applicability limited by amount representative,...
Abstract Physiological changes in GTP levels live cells have never been considered a regulatory step of RAC1 activation because intracellular concentration (determined by chromatography or mass spectrometry) was shown to be substantially higher than the vitro dissociation constant (RAC1-GTP Kd). Here, combining genetically encoded biosensors and activity biosensor, we demonstrated that fluctuating around RAC1-GTP Kd correlated with cells. Furthermore, co-localized protrusions invading...
The dnaN159 allele encodes a temperature-sensitive mutant form of the β sliding clamp (β159). SOS-induced levels DNA polymerase IV (Pol IV) confer UV sensitivity upon strain, while Pol ∼4-fold higher than those induced by SOS response severely impede its growth. Here, we used mutations in that disrupted specific interactions with to test our hypothesis these phenotypes were result gaining inappropriate access replication fork via III*-Pol switch relying on both rim and cleft clamp. Our...
Resistance to the proteasome inhibitor bortezomib (BTZ) represents a major obstacle in treatment of multiple myeloma (MM). The contribution lipid metabolism resistance MM cells BTZ is mostly unknown. Here we report that levels fatty acid elongase 6 (ELOVL6) were lower from BTZ-nonresponsive vs BTZ-responsive patients and cultured selected for compared with parental counterparts. Accordingly, depletion ELOVL6 suppressed BTZ-induced endoplasmic reticulum (ER) stress cytotoxicity, whereas...
Master transcription factor MyoD can initiate the entire myogenic gene expression program which differentiates proliferating myoblasts into multinucleated myotubes. We previously demonstrated that histone methyltransferase KMT1A associates with and inhibits in myoblasts, must be removed to allow differentiation proceed. It is known pro-myogenic signaling pathways such as PI3K/AKT p38α MAPK play critical roles enforcing associations between transcriptional activators, while removing...
Due to the low environmental concentrations and substance-specific behavior of trace organic chemicals (TOrCs), general mechanistic insights can hardly be gained from biotransformation studies with individual substances. In this study, we aimed identify prevalent enzymatic reactions under different redox substrate conditions in a well-defined laboratory-scale column system. Biotransformation first column, which was characterized by relatively high biomass rapid depletion dissolved oxygen,...
Three randomly amplified polymorphic DNA (RAPD) markers (E07, G17, and 596) linked to the Fom-2 gene, which confers resistance race 0 1 of Fusarium oxysporum f. sp. melonis , were evaluated by RAPD-polymerase chain reaction for their linkage wilt resistance/susceptibility in diverse melon cultigens (48 resistant, 41 susceptible). Primer 596 was identified multiple disease-resistant breeding line MR-1, whereas E07 G17 susceptible `Vedrantais'. The RAPD (1.25 kb) (1.05 correctly matched...
We conducted a field screening of melon ( Cucumis melo L.) cultigens to identify potential sources host-plant resistance Monosporascus cannonballus Pollack & Uecker. Seed were sown in Speedling trays with inoculated or noninoculated media. Plants transplanted into known be highly infested M. . Cultigens arranged randomized complete block three replications each treatment (fumigated/noninoculated, nonfumigated/inoculated). Vine decline (1 = no symptoms 5 dead vines) was rated at 78 and 90...
The fungus Monosporascus cannonballus Pollock and Uecker infects melon ( Cucumis melo L.) roots causes root rot/vine decline disease, which has reduced productivity of commercial muskmelon honeydew cultivars in South Texas. To assess the impact on several traits, two greenhouse experiments were carried out over seasons. A comparison inoculated vs. control systems was with four representing both susceptible (`Magnum 45' `Caravelle') tolerant types (`Deltex' `Doublon'). sand medium 50–60...
RNA processing and transport are mediated by cotranscriptionally assembled ribonucleoprotein (RNP) complexes. RNPs have been postulated to help specify coordinated gene expression, but the requirements for specific RNP complexes in mammalian development tissue homeostasis not extensively evaluated. THO is an evolutionarily conserved complex that links transcription with nuclear export. essential Saccharomyces cerevisiae viability, it early mouse embryonic development. Embryonic lethality has...
Biofiltration processes help to remove trace organic chemicals (TOrCs) both in wastewater and drinking water treatment systems. However, the detailed TOrCs biotransformation mechanisms as well underlying drivers behind variability of site specific transformation remain elusive. In this study, we used laboratory batch incubations investigate 51 eight bioactive filter materials different origins treating a range waters, from effluents water. Microscopy, 16S rRNA amplicon whole metagenome...
Alveolar rhabdomyosarcoma (aRMS) is an aggressive subtype of the most common soft tissue cancer in children. A hallmark aRMS tumors incomplete myogenic differentiation despite expression master regulators such as MyoD. We previously reported that histone methyltransferase KMT1A suppresses MyoD function to maintain undifferentiated state cells, and loss sufficient induce suppress malignant phenotypes these cells. Here, we develop a chemical compound screening approach using MyoD-responsive...
Two field studies were conducted to compare bentazon tolerance in “Bohemian Chili” (BCH) and “Keystone Resistant Giant” (KRG) with other pepper cultivars plant introductions (PIs). In the first study, BCH, KRG, “Santaka” (SA), “Sweet Banana” (SB) treated five rates of from 1.1 9.0 kg ai/ha. Based on foliar injury, ranked BCH = SA < KRG SB; based yield bentazon, they ≤ SB BCH. second response SA, SB, PIs 4.5 kg/ha showed that 3 (127445, 163187, 246123) tolerated similarly SA.