A5082119936- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Brucella: diagnosis, epidemiology, treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- RNA Research and Splicing
- Cardiovascular and Diving-Related Complications
- HIV Research and Treatment
- Streptococcal Infections and Treatments
- Zoonotic diseases and public health
- Healthcare and Environmental Waste Management
- Liver Disease and Transplantation
- Inflammasome and immune disorders
- Viral Infections and Vectors
- Hepatitis Viruses Studies and Epidemiology
- Air Quality and Health Impacts
- Global Public Health Policies and Epidemiology
- RNA and protein synthesis mechanisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiac Arrest and Resuscitation
- Asthma and respiratory diseases
- Animal Disease Management and Epidemiology
- RNA modifications and cancer
Alexandria University
2015-2024
The Ohio State University
2019-2022
Gladstone Institutes
2021
University of California, San Francisco
2021
Architecture et Réactivité de l'arN
2014-2016
Université de Strasbourg
2014-2016
Centre National de la Recherche Scientifique
2014-2016
Kumamoto University
2015
The HIV-1 Pr55Gag precursor specifically selects genomic RNA (gRNA) from a large variety of cellular and spliced viral RNAs (svRNAs), however the molecular mechanisms this selective recognition remains poorly understood. To gain better understanding process, we analyzed interactions between panel (vRNA) fragments encompassing main packaging signal (Psi) its flanking regions by fluorescence spectroscopy. We showed that gRNA harbors high affinity binding site which is absent svRNA species,...
MicroRNAs (miRNAs) are about 22-nucleotide (nt) noncoding RNAs forming the effector complexes with Argonaute (AGO) proteins to repress gene expression. Although tiny (tyRNAs) shorter than 19 nt have been found bind plant and vertebrate AGOs, their biogenesis remains a long-standing question. Here, our in vivo vitro studies show several 3′→5′ exonucleases, such as interferon-stimulated 20 kDa (ISG20), three prime repair exonuclease 1 (TREX1), ERI1 (enhanced RNAi, also known 3′hExo), capable...
The study relevance is associated with remote negative effects produced by diving on health and related to high fatality rates. Research cardiovascular risk assessment (CVRA) in divers scarce. We aimed evaluate the accuracy of some novel biomarkers versus an established estimator CVRA among professional divers. A comparative cross-sectional was conducted a total 50 equal number marine seafarers. Participants were clinically evaluated subjected electrocardiography (ECG), basic biochemical...
The study relevance is associated with remote negative effects produced by diving on health and related to high fatality rates. Research cardiovascular risk assessment (CVRA) in divers scarce. We aimed evaluate the accuracy of some novel biomarkers versus an established estimator CVRA among professional divers. A comparative cross-sectional was conducted a total 50 equal number marine seafarers. Participants were clinically evaluated subjected electrocardiography (ECG), basic biochemical...
Solid-waste management is associated with several health hazards, particularly parasitic infection. The objective of the study was to determine association between risk factors and occurrence intestinal infections (potentially pathogenic) among municipal waste collectors in Alexandria, Egypt. A cross-sectional survey conducted main municipality company Alexandria. total 346 solid-waste workers (MSWWs) interviewed using an in-depth questionnaire. type handlers determined formol–ether...
Written personalized asthma action plans are recommended as part of patient education and self-management.To enable asthmatic adults to proactively self-manage bronchial sustain quiescent status through utilization the Asthma Action Plan (AAP), establish a feasible asthmatic/care taker-health care provider communication.Randomized controlled trial with cluster sampling by pulmonologists.The study comprised 320 chronic patients attending chest department at main health insurance hospital in...
Brucellosis is a highly contagious zoonosis affecting humans and wide range of domesticated wild animal species. An important element for effective disease containment to improve knowledge, attitudes practices (KAP) afflicted communities. This study aimed assess the KAP related brucellosis at human-animal interface in an endemic area Egypt identify risk factors human infection. A matched case-control was conducted central fever hospitals located six governorates northern Egypt. Face-to-face...
Background More than ten million Egyptians are infected with HCV. Every one of them is going to infect about three four persons every year. Treating those patients a matter national security. A dramatic improvement in hepatitis C virus (HCV) infection treatment was achieved the last five years. new era direct-acting antivirals now dawning Egypt. Objective(s) We share this report our clinical experience treating chronic HCV Egyptian Sofosbuvir based regimens evaluate its safety and efficacy...
Background: Metabolic syndrome (MetS) is a cluster of cardiometabolic disturbances that increases the risk cardiovascular diseases (CVD) and type 2 diabetes mellitus (DM). The early identification high-risk individuals key for halting these conditions. world facing growing epidemic MetS although magnitude in Egypt unknown. Objectives: To describe its determinants among apparently healthy residing urban rural communities to establish model prediction. Methods: A cross-sectional study was...
Fever of unknown origin (FUO) is one the most challenging diagnostic dilemmas in field infectious diseases and tropical medicine. Clinicians should use frequency distribution disorders causing FUO to guide their approach patients with prolonged, unexplained fevers meeting definition FUO.The present study was undertaken examine etiologies, clinico-epidemiologic profile, prognosis classical reporting Alexandria Hospital Egypt. Records 979 admitted fever hospital (from January 2009 2010)...
Introduction: Travel health practice and research in Egypt lag behind both needs demands. This study was done two parts to assess travel knowledge, attitude, (KAP) among Egyptian travelers. Methods: survey conducted at the departure halls of Cairo International Airport included 1500 travelers Africa (excluding North Africa), Southeast Asia, Latin America. An interview questionnaire used measure KAP inquiring about different aspects pre-travel health. Subjective evaluations services...
Fibrocytes (fibroblastic leukocytes) are recently identified as unique hematopoietic cells with features of both macrophages and fibroblasts. known to contribute the remodeling or fibrosis various injured tissues. However, their role in viral infection is not fully understood. In this study, we show that differentiated fibrocytes phenotypically distinguishable from but can be infected HIV-1. Importantly, exhibited persistently cell-like phenotypes, degree which was more apparent than...
Abstract Background Brucellosis is a highly contagious zoonosis affecting human and almost all domestic species. It multi-burdens disease leading to severe economic losses due disability in humans addition abortion, infertility reduced milk production animals. An Important element for effective prevention control of brucellosis improve knowledge, attitude practices the community. Objective(s) This study aimed assess attitudes (KAP) related at human-animal interface determine risk factors...
Rheumatic heart disease (RHD) as a chronic sequela of repeated episodes acute rheumatic fever (ARF), remains cause cardiac morbidity in Egypt although it is given full attention through national RHD prevention and control program. The present report reviews our experience with subjects presenting ARF or its sequelae single centre describes the pattern over last decade. A cross-sectional study was conducted El-Mahalla between 2006 2018. total 17014 individual were enrolled evaluated....
Professional divers are exposed to unique multifactorial hazards in their working environment and adverse cardiovascular effects such as ischemia, arrhythmia, stroke, death associated with professional diving. Cardiovascular events aggravated by diving-induced oxidative stress account for one-fourth of diving fatalities. This study aimed measure a group Alexandria, Egypt using panel biomarkers. A comparative cross-sectional was conducted between June 2017 May 2018 at the General Naval...
Asymptomatic patients with HCV infection identified through screening program could benefit not only from treatment but also other interventions such as counseling to maintain health and avoid risk behaviors. This might prevent the spread of result in significant public benefits. However, mass would quickly deplete resources. work aims develop a brief assessment questionnaire that inquires initially about wide range factors found be potentially associated order identify few most questions...