A5074473858- Meta-analysis and systematic reviews
- Nutritional Studies and Diet
- Parathyroid Disorders and Treatments
- Obesity, Physical Activity, Diet
- Health Systems, Economic Evaluations, Quality of Life
- Diet and metabolism studies
- Genetic Syndromes and Imprinting
- Consumer Attitudes and Food Labeling
- Food Security and Health in Diverse Populations
- Health Policy Implementation Science
- Nutrition and Health in Aging
- Health and Medical Research Impacts
- Bone health and osteoporosis research
- Sex and Gender in Healthcare
- Genetics, Aging, and Longevity in Model Organisms
- Genetic and Kidney Cyst Diseases
- Muscle metabolism and nutrition
- Mental Health Research Topics
- Child Nutrition and Water Access
- Magnesium in Health and Disease
- Folate and B Vitamins Research
- Birth, Development, and Health
- Advanced Causal Inference Techniques
- Vitamin C and Antioxidants Research
- Statistical Methods in Clinical Trials
Indiana University Bloomington
2019-2025
Indiana University
2021-2024
Purdue University West Lafayette
2017-2022
State Street (United States)
2017
University of Wisconsin–Stout
2014
Importance Publishing study protocols might reduce research waste because of unclear methods or incomplete reporting; on the other hand, there be few additional benefits publishing for registered trials that are never completed published. No has investigated proportion published associated with results. Objective To estimate trial which not Design, Setting, and Participants This cross-sectional used stratified random sampling to identify clinical between January 2011 August 2022 indexed in...
Abstract Complete and transparent reporting of randomized controlled trial publications (RCTs) is essential for assessing their credibility. We aimed to develop text classification models determining whether RCT report CONSORT checklist items. Using a corpus annotated with 37 fine-grained items, we trained sentence (PubMedBERT fine-tuning, BioGPT in-context learning GPT-4) compared performance. assessed the impact data augmentation methods (Easy Data Augmentation (EDA), UMLS-EDA, generation...
Randomized controlled trials (RCTs) can produce valid estimates of the benefits and harms therapeutic interventions. However, incomplete reporting undermine validity their conclusions. Reporting guidelines, such as SPIRIT for protocols CONSORT results, have been developed to improve transparency in RCT publications. In this study, we report a corpus 200 publications, named SPIRIT-CONSORT-TM, annotated transparency. We used comprehensive data model that includes 83 items from checklists...
Publishing protocols promotes transparency and reproducibility. The scope methods of for nutrition- diet-related randomized controlled trials (RCTs) have not been investigated yet. Map the landscape interventions research. We conducted a meta-research nutrition-and RCT published between January 2012 March 2022, in any language, targeting human participants, evaluating nutrition isolated or combined. A systematic search literature was six online databases. Bibliometric information, study...
Abstract Randomized controlled trials (RCTs) can produce valid estimates of the benefits and harms therapeutic interventions. However, incomplete reporting undermine validity their conclusions. Reporting guidelines, such as SPIRIT for protocols CONSORT results, have been developed to improve transparency in RCT publications. In this study, we report a corpus 200 publications, named SPIRIT-CONSORT-TM, annotated transparency. We used comprehensive data model that includes 83 items from...
Clustering effects, such as those introduced by housing animals in shared cages, are often overlooked preclinical lifespan studies, despite their potential to distort variance estimates and inflate Type I error rates, leading misleading conclusions. This methodological oversight reduces statistical rigor may undermine the reliability of findings. To address this gap, current study examines impact accounting for clustering nesting effects on analyses comparing results models which both...
<ns3:p>Background Variables such as dietary intake are measured with error yet frequently used in observational epidemiology. Although this limitation is sometimes noted, these variables still often modeled covariates without formal correction or sincere dialogue about measurement unreliability potentially weakening the validity of statistical conclusions. Further, larger sample sizes increase power (bias) to detect spurious correlations. Counterintuitively, recent work suggested a...
The Cy/+ rat has been characterized as a progressive model of chronic kidney disease-mineral bone disorder (CKD-MBD). We aimed to determine the effect disease progression on intestinal phosphorus absorption and whole-body balance in this model. A total 48 (CKD) normal littermates (NL) rats were studied at two ages: 20 weeks 30 weeks, function decline approximately 50% 20% function. Sodium-dependent sodium-independent efficiency measured by situ jejunal ligated loop method using 33 P...
Abstract Background The aim of the INSPECT-SR project is to develop a tool identify problematic RCTs in systematic reviews. In Stage 1 project, list potential trustworthiness checks was created. on this must be evaluated determine which should included tool. Methods We attempted apply 72 50 Cochrane Reviews. For each, we recorded whether check passed, failed or possibly failed, it not feasible complete check. Following application checks, had concerns about authenticity each RCT. repeated...
Abstract Male Cy/+ rats have shown a relatively consistent pattern of progressive kidney disease development that displays multiple key features late stage chronic disease-mineral bone disorder (CKD-MBD), specifically the cortical porosity. However, progression in female rats, assessed limited studies, is more heterogeneous and to date has failed show CKD-MBD phenotype, thus limiting their use as practical model CKD-MBD. Animal human studies suggest estrogen may be protective against...
Intestinal phosphorus absorption is an important component of whole-body metabolism, and limiting dietary particularly interest as a therapeutic target in patients with chronic kidney disease to manage mineral bone disorders. Yet, mechanisms regulation intestinal have not been adequately studied discrepancies findings exist based on the assessment technique used. In vitro techniques show rather consistent effects intake level age sodium-dependent phosphate transport. But, few studies that...
Abstract Although randomisation has long been seen as crucial to reaching reliable insights from data, it is still falling victim some peculiar – and troublesome misconceptions. By Arthur H. Owora, John Dawson, Gary Gadbury, Luis M. Mestre, Greg Pavela, Tapan Mehta, Colby J. Vorland, Pengcheng Xun David B. Allison