A5069309585- COVID-19 and healthcare impacts
- Endometriosis Research and Treatment
- Meta-analysis and systematic reviews
- Infection Control and Ventilation
- Ovarian function and disorders
- COVID-19 and Mental Health
- Pelvic floor disorders treatments
- Breast Implant and Reconstruction
- Spatial Neglect and Hemispheric Dysfunction
- Health Systems, Economic Evaluations, Quality of Life
- Assisted Reproductive Technology and Twin Pregnancy
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Breast Cancer Treatment Studies
- Health and Medical Research Impacts
- Musculoskeletal pain and rehabilitation
- Dermatologic Treatments and Research
- Skin Diseases and Diabetes
- Genetic factors in colorectal cancer
- Pregnancy-related medical research
- Neurosurgical Procedures and Complications
- Simulation-Based Education in Healthcare
- Teratomas and Epidermoid Cysts
- Death, Funerary Practices, and Mourning
- Diabetic Foot Ulcer Assessment and Management
Manchester Academic Health Science Centre
2019-2025
University of Manchester
2019-2025
Public Health Ontario
2021-2023
Wythenshawe Hospital
2019-2022
Manchester University
2022
Greater Manchester Mental Health NHS Foundation Trust
2022
Manchester University NHS Foundation Trust
2019-2020
St Mary's Hospital
2020
Concern remains about how occupational SARS-CoV-2 risk has evolved during the COVID-19 pandemic. We aimed to ascertain occupations with greatest of infection and explore relative differences varied over
Purpose: Recombinant human interleukin-1 receptor antagonist (anakinra) is an anti-inflammatory with efficacy in animal models of stroke. We tested the effect anakinra on perihaematomal oedema acute intracerebral haemorrhage (ICH) and explored effects inflammatory markers. Methods: conducted a multicentre, randomised, double-blind, placebo-controlled trial patients acute, spontaneous, supratentorial ICH between May 2019 February 2021. Patients were randomised to 100 mg subcutaneous within 8...
Introduction Ivacaftor was the first therapy licensed to address underlying defect in cystic fibrosis (CF). The improvements lung function, nutritional status and pulmonary exacerbations patients carrying a Gly551Asp mutation were greater than previously seen clinical trials for other therapies. Limited data are available regarding long-term outcomes adherence ivacaftor outside trials. Methods We conducted 5-year single-centre retrospective study of people with CF Gly 551 Asp who received...
Noninvasive quantitative assessment of dermal fibrosis remains a challenge. Optical coherence tomography (OCT) and high‐frequency ultrasound (HFUS) can accurately measure structural physiological changes in skin. To perform analysis cutaneous fibrosis. Sixty‐two healthy volunteers underwent multiple sequential skin biopsies (day 0 1–8 weekly thereafter), with OCT HFUS measurements at each time point supported immunohistomorphometry analysis. provided thickness, which increased from uninjured...
The levonorgestrel-releasing intrauterine system (LNG-IUS) is a conservative management option for atypical hyperplasia (AH) and low grade early stage endometrial cancer (EEC), but around 1 in 3 patients fail to respond treatment. aim of this study was investigate if serum and/or tissue HE4 expression could predict response LNG-IUS therapy. Patients with AH or presumed Stage I EEC had samples taken at baseline 3-month intervals over 12 months post-insertion LNG-IUS. 74 were recruited...
<ns3:p>There are important differences in the risk of SARS-CoV-2 infection and death depending on occupation. Infections healthcare workers have received most attention, there clearly increased risks for intensive care unit who caring COVID-19 patients. However, a number other occupations may also be at an risk, particularly those which involve social or contact with public.</ns3:p><ns3:p> A large data sets available potential to assess occupational incidence, severity, mortality. We...
<ns4:p>There are important differences in the risk of SARS-CoV-2 infection and death depending on occupation. Infections healthcare workers have received most attention, there clearly increased risks for intensive care unit who caring COVID-19 patients. However, a number other occupations may also be at an risk, particularly those which involve social or contact with public.</ns4:p><ns4:p> A large data sets available potential to assess occupational incidence, severity, mortality. We...
Abstract Background The aim of the INSPECT-SR project is to develop a tool identify problematic RCTs in systematic reviews. In Stage 1 project, list potential trustworthiness checks was created. on this must be evaluated determine which should included tool. Methods We attempted apply 72 50 Cochrane Reviews. For each, we recorded whether check passed, failed or possibly failed, it not feasible complete check. Following application checks, had concerns about authenticity each RCT. repeated...
A barrier to Lynch syndrome testing is the need for prior genetic counselling, a resource demanding process both patients and healthcare services. We explored impact of gynaecologist led in women with endometrial cancer. Women were approached before surgery, on day surgery or during routine follow up. was offered irrespective age, family history tumour characteristics. Women's reasons being tested using Motivations Concerns GeNEtic Testing (MACGNET) instrument. The short form State-Trait...
Background Screening with cardiac non-invasive stress studies (NISS) prior to listing for kidney transplantation can help in identifying treatable coronary disease and is considered an integral part of pre-kidney transplant evaluation. However, few assessed their effectiveness all patients evaluated clinical practice. To evaluate the role NISS evaluation we analyzed impact waitlisting 1053 adult CKD-5 consecutively Greater Manchester, UK during a 6-year period. Methods 918 waitlisted were...
Summary Background Bag–valve–mask ( BVM ) ventilation is a vital skill in the management of collapsed patient; however, quality cause for concern. Modified techniques, designed to be easier novice practitioner, offer an opportunity improve quality. One such modification ‘ LASOO ’ (Lift, Apply, Slide, Oppose, Observe) approach, which offers theoretical benefits over traditionally taught CE (finger shapes) technique. We conducted randomised controlled trial RCT determine whether was superior...
Introduction: Nigeria has a large estimated burden of AIDS-related mycoses. We aimed to determine the proportion pa- tients with opportunistic fungal infections (OFIs) at an urban antiretroviral treatment (ART) centre in Nigeria.
 Methods: A retrospective analysis cohort ART-naïve, HIV-infected patients, assessed for ART eligibility and ART- experience PEPFAR outpatient clinic Lagos University Teaching Hospital over 12-year period (April 2004-Feb- ruary 2016) was conducted.
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Abstract Background Considerable concern remains about how occupational SARS-CoV-2 risk has evolved during the COVID-19 pandemic. We aimed to ascertain which occupations had greatest of infection and explore relative differences varied over Methods Analysis cohort data from UK Office National Statistics Coronavirus (COVID-19) Infection Survey April 2020 November 2021. This survey is designed be representative population uses regular PCR testing. Cox multilevel logistic regression compare...
Objective Investigate feasibility and acceptability of prism adaptation training for people with inattention (spatial neglect), early after stroke, during usual care. Design Phase II randomised controlled trial 3:1 stratified allocation to standard occupational therapy or without intervention, nested process evaluation. Setting Ten hospital sites providing in-patient stroke services. Participants Screened positive more than one-week post-stroke; informal carers. Occupational therapists...
Women with breast cancer-related genetic pathogenic variants (e.g., BRCA1 , BRCA2 ) or a strong family history carry lifetime risks of developing cancer up to 80 90 percent. A significant proportion these women proceed bilateral risk-reducing mastectomy. The authors aimed document the surgical morbidity mastectomy and establish whether diagnosis at time surgery impacted outcomes.Clinical details 445 identified as having greater than 25 percent risk who underwent reconstruction were...