Raphaela Cassol Piccoli

ORCID: 0000-0003-4247-2615
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About
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Research Areas
  • Phytochemicals and Antioxidant Activities
  • Tryptophan and brain disorders
  • Natural Antidiabetic Agents Studies
  • Alzheimer's disease research and treatments
  • Circadian rhythm and melatonin
  • Advanced Nanomaterials in Catalysis
  • Agricultural and Food Sciences
  • Diet and metabolism studies
  • Nanoplatforms for cancer theranostics
  • Cholinesterase and Neurodegenerative Diseases
  • Diet, Metabolism, and Disease
  • Exercise and Physiological Responses
  • Stress Responses and Cortisol
  • Gut microbiota and health
  • Nanoparticle-Based Drug Delivery
  • Nuts composition and effects

Universidade Federal de Pelotas
2022-2025

Type 2 diabetes mellitus (T2DM) is a multifaceted metabolic disorder characterized by insulin resistance and pancreatic β-cell dysfunction, leading to varying insults. Grape pomace, byproduct of the winemaking industry, under investigation as potential therapy for T2DM due its abundant content bioactive polyphenols dietary fiber. Within current backdrop environmental concerns, conversion grape pomace into safe applicable form, with aim promoting sustainable management waste, acts catalyst...

10.1152/physiol.2024.39.s1.1413 article EN Physiology 2024-05-01

Background/Objectives: Type 2 Diabetes Mellitus (T2DM) is characterized by hyperglycemia, increased risk of cardiovascular diseases, and oxidative imbalances. This study aimed to investigate the impact dietary supplementations with ‘Arinto’ grape pomace flour (GPF) (WGPF) ‘Touriga Nacional’ GPF (RGPF) in an animal model T2DM. Methods: T2DM was induced a high-fat diet (HFD) for 28 days single dose streptozotocin (STZ) (35 mg/kg) on 21st day. Forty adult male Wistar rats were divided into five...

10.3390/ph17111530 article EN cc-by Pharmaceuticals 2024-11-14

Grape pomace (GP) is a by-product of wine industry that despite its substantial bioactive compounds content vastly discarded during winemaking process. The present review aimed to summarize recent evidence on the biological, metabolic, nutritional and sensory properties grape flour (GPF) supplemented foods administrated different models. In this sense, search was carried out in electronic databases “PubMed”, “Google Scholar” “SCOPUS” comprised studies used as totality for productions. GPF...

10.19277/bbr.19.2.296 article EN Biomedical and Biopharmaceutical Research 2022-01-01
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