A5025540337- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of heterocyclic compounds
- Synthesis and Reactions of Organic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthesis and Biological Evaluation
- Fluorine in Organic Chemistry
- Multicomponent Synthesis of Heterocycles
- Phenothiazines and Benzothiazines Synthesis and Activities
- Crystal structures of chemical compounds
- Malaria Research and Control
- Free Radicals and Antioxidants
- Cholinesterase and Neurodegenerative Diseases
- Sulfur-Based Synthesis Techniques
- HIV/AIDS drug development and treatment
- Chemical Synthesis and Analysis
- Crystallography and molecular interactions
- Computational Drug Discovery Methods
- Tuberculosis Research and Epidemiology
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Microwave-Assisted Synthesis and Applications
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Reactions
Universidade Federal de Pelotas
2016-2025
Instituto de Ciências Farmacêuticas
2011-2017
Universidade Federal da Grande Dourados
2014
Fundação Oswaldo Cruz
2007-2011
Universidade Federal de Santa Maria
2001-2008
Universidade Federal de Minas Gerais
2005
The preparation of 4-alkoxy-1,1,1-trichloro-3-alken-2-ones (enones), important synthetic tools for the heterocyclic synthesis, from cheap and easily accessible starting materials, is reported. applications enones in synthesis isoxazoles, pyrazoles, pyrimidines other heterocycles are also This review was grouped into two main sections: (i) derivatives (ii) synthesis. Keywords: enones, enol ethers, acetals, trichloromethyl-compounds,
1,3-Thiazolidin-4-ones are an important group of heterocyclic compounds that used in the field medicinal chemistry. The utility 1,3-thiazolidin-4-ones as synthons for various biological has given impetus to these studies. In recent years, 1,3-thiazoldin-4-ones have been among most extensively studied compounds. This review aims work reported on chemistry and activities during past few years. Keywords: Biological Activities, 1,3-Thiazolidin-4-ones, compounds, chemistry, synthons, Synthesis
The alternative synthesis of 12 1,2,4-oxadiazoles using ultrasound irradiation from trichloroacetoamidoxime and acyl chlorides is reported. Seven them are novel compounds. 3-trichloromethyl-5alkyl(aryl)-1,2,4-oxadiazoles have been synthesised in better yields shorter reaction times compared to the conventional method. This protocol can be applicable for preparation containing aryl or alkyl groups attached at their C-5 side-chain.
Pyrazoles are compounds of synthetic origin, and constitute a group nitrogen heterocyclic that have shown several biological activities. Their transformations into other biologically active molecules been exploited since the early 1960s. This review describes work on environment-friendly synthesis bioactive pyrazoles. The covers mainly data published over last five years (2007–2012).
Thirteen new hydroxyethylamines have been synthesized from reactions of (2S,3S)Boc-phenylalanine epoxide, piperonylamine and arenesulfonyl chlorides in good yields. These compounds were evaluated as antibacterial agents against Mycobacterium tuberculosis H37Rv using the Alamar Blue susceptibility test their activity expressed minimum inhibitory concentration (MIC) μM. Two amino alcohols displayed significant when compared with first line drug ethambutol (EMB). Therefore this class could be a...
Glioblastoma is the most devastating primary brain tumor. Current treatment palliative, making necessary development of new therapeutic strategies to offer alternatives patients. Therefore, endophytes represent an interesting source natural metabolites with anticancer potential. These microorganisms reside in tissues living plants and act improve their growth. Evidence revealed that several medicinal are colonized by endophytic fungi producer antitumor metabolites. Achyrocline satureioides a...
Glioblastoma multiforme (GBM) is the worst form of primary brain tumor, which has a high rate infiltration and resistance to radiation chemotherapy, resulting in poor prognosis for patients. Recent studies show that thiazolidinones have wide range pharmacological properties including antimicrobial, anti-inflammatory, anti-oxidant anti-tumor. Here, we investigate effect antiglioma vitro panel sixteen synthetic 2-aryl-3-((piperidin-1-yl)ethyl)thiazolidin-4-ones where 13 these decreased...