A5004744370- Tryptophan and brain disorders
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Vitamin C and Antioxidants Research
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Anesthesia and Neurotoxicity Research
- Medicinal Plants and Neuroprotection
- Pharmacological Effects of Natural Compounds
- Birth, Development, and Health
- Natural Antidiabetic Agents Studies
- Sulfur Compounds in Biology
- Memory and Neural Mechanisms
- Folate and B Vitamins Research
- Telomeres, Telomerase, and Senescence
- Biochemical Acid Research Studies
- Biochemical Analysis and Sensing Techniques
- Retinoids in leukemia and cellular processes
- Bipolar Disorder and Treatment
- Protein Hydrolysis and Bioactive Peptides
- Circadian rhythm and melatonin
- Proteins in Food Systems
- Ion Transport and Channel Regulation
- Diet, Metabolism, and Disease
Universidade Federal de Pelotas
2020-2025
The aim of the current study was to evaluate effect chronic administration Eugenia uniflora fruit extract on behavioral parameters, oxidative stress markers, and acetylcholinesterase activity in an animal model depression, which induced by unpredictable (CUS). Mice were divided into six groups as follows: control/vehicle (water), control/fluoxetine (20 mg/kg), control/extract (200 CUS/vehicle, CUS/fluoxetine CUS/extract mg/kg). Animals CUS group exposed a series stressors for period 21 days....
Major depressive disorder is a debilitating and recurrent psychiatric disorder. Blueberries have several biological properties, including neuroprotective effects, through antioxidant anti-inflammatory actions. The aim of this study was to evaluate the effect blueberry extract on depressive-like behavior lipopolysaccharide (LPS)-induced neurochemical changes.Mice were pretreated with vehicle, fluoxetine (20 mg/kg) or (100 200 intragastrically for seven days before intraperitoneal LPS (0.83...
Alzheimer's disease (AD) is characterized mostly by memory decline. The current therapeutic arsenal for treating AD limited, and the available drugs only produce symptomatic benefits, but do not stop progression. search effective alternatives with multitarget actions therefore imperative. One such a potential alternative thiazolidin-4-one, compound that exhibits anti-amnesic, anticholinesterase, antioxidant activities. aim of this study was evaluated effects 2-(4-(methylthio)phenyl)−...
In the present study, we aimed to investigate protective effect of blueberry extract on behavioral, biochemical, and morphological changes in an experimental model lipopolysaccharide (LPS)-induced depressive behavior. Male Swiss mice were pretreated with vehicle, fluoxetine (20 mg/kg), or Vaccinium virgatum (100 mg/kg 200 mg/kg) for seven days. On day 7, animals administered LPS injection (0.83 vehicle. Pretreatment prevented LPS-induced depressive-like Moreover, increased serum levels total...
Abstract Aims This study aimed to assess metabolic responses and senescent cell burden in young female mice induced estropause treated with senolytic drugs. Main methods Estropause was by 4-vinylcyclohexene diepoxide (VCD) injection two-month-old mice. The senolytics dasatinib quercetin (D+Q) or fisetin were given oral gavage once a month from five 11 months of age. Key findings VCD-induced led increased body mass reduced albumin concentrations compared untreated cyclic mice, without...
Background/Objectives: Type 2 Diabetes Mellitus (T2DM) is characterized by hyperglycemia, increased risk of cardiovascular diseases, and oxidative imbalances. This study aimed to investigate the impact dietary supplementations with ‘Arinto’ grape pomace flour (GPF) (WGPF) ‘Touriga Nacional’ GPF (RGPF) in an animal model T2DM. Methods: T2DM was induced a high-fat diet (HFD) for 28 days single dose streptozotocin (STZ) (35 mg/kg) on 21st day. Forty adult male Wistar rats were divided into five...
Abstract Hypermethioninemia is characterized by high plasma concentrations of methionine (Met) and its metabolites, such as sulfoxide (MetO), neurological changes, cerebral edema cognitive deficits. The aim this study was to analyze the redox status acetylcholinesterase (AChE) activity in hippocampus, striatum, cerebellum young Wistar rats subjected an acute hypermethioninemia protocol. animals received, subcutaneous injection, a single dose Met (0.4 g/kg), MetO (0.1 + MetO, 1 or 3 hr after...