A5091547545- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Melanoma and MAPK Pathways
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Renal cell carcinoma treatment
- Cell Adhesion Molecules Research
- Child and Adolescent Psychosocial and Emotional Development
- Cannabis and Cannabinoid Research
- Substance Abuse Treatment and Outcomes
- Sleep and related disorders
- Cutaneous Melanoma Detection and Management
- Cancer Immunotherapy and Biomarkers
- Sulfur Compounds in Biology
- Orthopedic Surgery and Rehabilitation
- Renal and related cancers
- Bipolar Disorder and Treatment
- Genetic and rare skin diseases.
- Intracranial Aneurysms: Treatment and Complications
- Chemotherapy-induced organ toxicity mitigation
- Chronic Kidney Disease and Diabetes
- Youth Substance Use and School Attendance
- Hedgehog Signaling Pathway Studies
Seagen (United States)
2019-2023
University of Tennessee at Knoxville
2021-2022
Knoxville College
2022
New York University
2012-2016
VA NY Harbor Healthcare System
2012-2013
Columbia University Irving Medical Center
2012
Portland State University
2001
Using cannabis to reduce psychological and physical distress, referred as self-medication, is a significant risk factor for use disorder. To better understand this high-risk behavior, sample of 290 young adults (ages 18-25; 45.6% female) were recruited from two U.S. universities in January February 2020 complete survey about their self-medication. Results: seventy-six percent endorsed using problems such anxiety, sleep, depression, pain, loneliness, social discomfort, concentration. When...
SGN-CD228A is an investigational antibody-drug conjugate (ADC) directed to melanotransferrin (CD228, MELTF, MFI2, p97), a cell-surface protein first identified in melanoma. consists of humanized antibody, hL49, with high specificity and affinity for CD228 that stably conjugated 8 molecules the clinically validated microtubule-disrupting agent monomethyl auristatin E (MMAE) via novel glucuronide linker. We performed comprehensive IHC studies, which corroborated published RNA sequencing data...
Modulation of glutathione has been proposed as a mechanism to alter the efficacy and toxicity chemotherapeutic agents. We investigated in vitro cytoenhancement chemotherapy by reducing cellular levels with L-buthionine-[S,R]-sulfoximine (BSO), chemoprotection small molecular weight sulfur-containing agents that mimic or replace glutathione. Cytotoxicity, caspase-2 enzymatic activity, situ DNA staining for apoptosis were assessed cultured human cell lung carcinoma cells fibroblasts. BSO...
Papular acantholytic dyskeratosis (PAD) of the vulva is a rare, chronic disorder first described in 1984. It presents young women as white to skin-coloured smooth papules over vulva, which are persistent but asymptomatic. Histologically, there hyperkeratosis and focal parakeratosis with dyskeratotic cells forming corps ronds grains, placing PAD within Ackerman's spectrum dyskeratoses Hailey-Hailey disease (HHD) Darier disease. There have been 17 previous reports our knowledge. Only one...
Integrin beta-6, a component of the heterodimeric adhesion receptor alpha-v/beta-6, is overexpressed in numerous solid tumors. Its expression has been shown by multiple investigators to be negative prognostic indicator diverse cancers including colorectal, non-small cell lung, gastric, and cervical. We developed SGN-B6A as an antibody-drug conjugate (ADC) directed integrin beta-6 deliver clinically validated payload monomethyl auristatin E (MMAE) cancer cells. The antibody specific for does...
Background: Text-delivered prevention programs provide unique opportunities to deliver substance use interventions at-risk populations. Methods: A pilot randomized controlled trial was conducted test the feasibility, acceptability, and preliminary efficacy of a 4-week, automated personalized text-messaging program, designed reduce risk factors increase protective associated with adolescent misuse. Sixty-nine adolescents were recruited from Federally Qualified Health Care clinic...
Tubulocystic renal cell carcinoma (TC-RCC) is a rare tumor composed of well-differentiated tubules and cysts lined by neoplastic cells with eosinophilic cytoplasm prominent nucleoli. The origin the still controversial. TC-RCC typically arises unilaterally. Involvement both kidneys multifocal has not been reported. In this study we report first case bilateral TC-RCC. Immunohistochemical, cytogenetic ultrastructural studies suggest closely related to papillary RCC.
<h3>Background</h3> Ladiratuzumab vedotin (LV) is an investigational antibody-drug conjugate (ADC) composed of a humanized anti-LIV-1 IgG1 conjugated with monomethyl auristatin E (MMAE), microtubule-disrupting agent. LV targets LIV-1, protein expressed by various cancers. Along cytotoxic effect, has been shown to induce immunogenic cell death (ICD) in preclinical studies. currently being investigated as monotherapy and combination pembrolizumab patients metastatic breast cancer other solid...
Abstract Melanotransferrin (CD228/MFI2/MELTF) is a cell-surfaced glycosylphosphatidylinoitol (GPI)-anchored glycoprotein that belongs to the transferrin family of iron-binding proteins. CD228 was first described as an oncofetal protein highly expressed on malignant melanoma cells. Data from The Cancer Genome Atlas (TCGA) suggests has broad expression across many types carcinomas and it recently potential biomarker invasive colorectal carcinoma. In this study, we characterize using...
Melanotransferrin (CD228/MFI2/MELTF) is a cell-surfaced glycosylphosphatidylinoitol (GPI)-anchored glycoprotein that belongs to the transferrin family of iron-binding proteins. CD228 was first described as an oncofetal protein highly expressed on malignant melanoma cells. Data from The Cancer Genome Atlas (TCGA) suggests has broad expression across many types carcinomas and it recently potential biomarker invasive colorectal carcinoma. In this study, we characterize using immunohistochemical...
<p>Antibody humanization, binding assays, conjugation, mass spec, additional in vivo details</p>
<p>Figures S1-S9</p>
<p>Figures S1-S9</p>
<div>Abstract<p>SGN-CD228A is an investigational antibody–drug conjugate (ADC) directed to melanotransferrin (CD228, MELTF, MFI2, p97), a cell-surface protein first identified in melanoma. SGN-CD228A consists of humanized antibody, hL49, with high specificity and affinity for CD228 that stably conjugated 8 molecules the clinically validated microtubule-disrupting agent monomethyl auristatin E (MMAE) via novel glucuronide linker. We performed comprehensive IHC studies, which...
<div>Abstract<p>SGN-CD228A is an investigational antibody–drug conjugate (ADC) directed to melanotransferrin (CD228, MELTF, MFI2, p97), a cell-surface protein first identified in melanoma. SGN-CD228A consists of humanized antibody, hL49, with high specificity and affinity for CD228 that stably conjugated 8 molecules the clinically validated microtubule-disrupting agent monomethyl auristatin E (MMAE) via novel glucuronide linker. We performed comprehensive IHC studies, which...
<p>Antibody humanization, binding assays, conjugation, mass spec, additional in vivo details</p>
<p>Figures S1-S9</p>
<p>Antibody humanization, binding assays, conjugation, mass spec, additional in vivo details</p>
<p>Figures S1-S9</p>