A5101886364- Toxic Organic Pollutants Impact
- Environmental Toxicology and Ecotoxicology
- Effects and risks of endocrine disrupting chemicals
- Mercury impact and mitigation studies
- Birth, Development, and Health
- Zebrafish Biomedical Research Applications
- Nanoparticles: synthesis and applications
- Adipose Tissue and Metabolism
- Microplastics and Plastic Pollution
- Pharmaceutical and Antibiotic Environmental Impacts
- Vestibular and auditory disorders
- Heavy Metal Exposure and Toxicity
- Liver Disease Diagnosis and Treatment
- Pesticide Exposure and Toxicity
- Metabolomics and Mass Spectrometry Studies
- Visual perception and processing mechanisms
- Asthma and respiratory diseases
- Pesticide and Herbicide Environmental Studies
- Biochemical effects in animals
- Pediatric health and respiratory diseases
- Nutritional Studies and Diet
- Chemical Analysis and Environmental Impact
- Mitochondrial Function and Pathology
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
Chinese Academy of Sciences
2016-2025
State Key Laboratory of Freshwater Ecology and Biotechnology
2021-2025
Riverside Hospital of Guangxi Zhuang Autonomous Region
2024-2025
Institute of Hydrobiology, Biology Centre, Academy of Sciences of the Czech Republic
2025
Institute of Hydrobiology
2013-2024
First People's Hospital of Chongqing
2024
Songjiang District Central Hospital
2024
The University of Sydney
2023
Changchun University
2022
Shantou University
2022
A novel brominated flame retardant decabromodiphenyl ethane (DBDPE) has become a ubiquitous emerging pollutant; hence, the knowledge of its long-term toxic effects and underlying mechanism would be critical for further health risk assessment. In present study, multi- transgenerational toxicity DBDPE was investigated in zebrafish upon life cycle exposure at environmentally relevant concentrations. The significantly increased malformation rate declined survival specifically occurred unexposed...
Decabromodiphenyl ethane (DBDPE), a novel brominated flame retardant, is becoming increasingly prevalent in environmental and biota samples. While DBDPE has been shown to cause various biological adverse effects, the molecular mechanism behind these effects still unclear. In this research, zebrafish embryos were exposed (50-400 μg/L) until 120 h post fertilization (hpf). The results confirmed neurotoxicity by increased average swimming speed, interfered neurotransmitter contents,...
The aim of the present study was to investigate acute developmental neurotoxicity polybrominated diphenyl ethers (PBDEs) in zebrafish larvae. From 2 120 h postfertilization embryos were exposed DE-71 (0, 31.0, 68.7, and 227.6 µg/L). authors studied locomotor behavior larvae, involvement cholinergic system, selected gene protein expressions central nervous system. results showed that low concentration caused hyperactivity, whereas higher concentrations decreased activity during dark period....
The disease take-all, caused by the fungus Gaeumannomyces graminis, is one of most destructive root diseases wheat worldwide. Breeding resistant cultivars an effective way to protect from take-all. However, little progress has been made in improving resistance level commercial cultivars. MYB transcription factors play important roles plant responses environmental stresses. In this study, R2R3-MYB gene Thinopyrum intermedium, TiMYB2R-1, was cloned and characterized. sequence includes two...
In the current study, adult male zebrafish fed a normal diet (ND) or high-fat (HFD) were exposed to niclosamide (NIC) at environmentally relevant concentrations reveal accumulation and distribution in different tissues evaluate effects on liver-gut axis. Chemical analysis indicated that liver bore greater burden of NIC compared with brain gonads zebrafish, HFD-fed fish their than those ND-fed fish. The indications from body weight, growth rate, mass index, micro-CT images, biochemical...
The novel brominated flame retardant decabromodiphenyl ethane (DBDPE) has become a ubiquitous emerging pollutant in the environment, which may evoke imperceptible effects humans or wild animals. Hence this study, zebrafish embryos were exposed to DBDPE (0, 0.1, 1, and 10 nM) until sexual maturity (F0), F1 F2 generations cultured without further exposure study multi- transgenerational toxicity underlying mechanism. growth showed sex-different changing profiles across three generations, social...
An emerging environmental contaminant, bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH), can bioaccumulate in the liver and affect hepatic lipid metabolism. However, in-depth mechanism has yet to be comprehensively explored. In this study, we utilized transgenic zebrafish Tg (Apo14: GFP) image interference of TBPH on development metabolism at early stage. Using integrated lipidomic transcriptomic analyses profile remodeling effect, uncovered potential effects lipophagy-related signaling...
More is to be explored between dietary patterns and sleep quality in the Chinese adult population.
<h3>Background and aims</h3> Administration of repeated lipopolysaccharide (LPS) injections in alcohol-fed rats leads to significant pancreatic injury including fibrosis. However, it remains unknown whether alcoholic (chronic) pancreatitis has the potential regress when alcohol is withdrawn. The aims study were (1) compare effect withdrawal/continuation on acute fibrosis; (2) assess effects ± LPS stellate cell (PSC) apoptosis vivo vitro. <h3>Methods</h3> Rats fed isocaloric Lieber–DeCarli...
Both visual and vestibular sensory cues are important for perceiving one's direction of heading during self-motion. Previous studies have identified multisensory, heading-selective neurons in the dorsal medial superior temporal area (MSTd) ventral intraparietal (VIP). MSTd VIP strong recurrent connections with pursuit frontal eye field (FEFsem), but whether FEFsem may contribute to multisensory perception remain unknown. We characterized tuning macaque visual, vestibular, stimuli. About...
Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH), a novel brominated flame retardant, can potentially cause lipid metabolism disorder; however, its biological effects on homeostasis remain unknown. We investigated ability to nonalcoholic fatty liver disease (NAFLD) in zebrafish. Female zebrafish were fed high-fat diet (HFD, 24% crude fat) or normal (ND, 6% fat), and exposed TBPH (0.02, 2.0 μM) for 2 weeks. Consequently, HFD-fed fish showed higher measured concentration of than ND-fed...
The novel brominated flame retardant decabromodiphenyl ethane (DBDPE) has become a widespread environmental pollutant. However, the target tissue and toxicity of DBDPE are still not clear. In current study, female zebrafish were exposed to 1 100 nM for 28 days. Chemical analysis revealed that tended accumulate in brain other than liver gonad. Subsequently, tandem mass tag-based quantitative proteomics parallel reaction monitoring verification performed screen differentially expressed...
Abstract Great concern has been raised over the potential impact of environmental contaminants on fish populations that inhabit Three Gorge Reservoir. The present study investigated endocrine‐disrupting effects di‐(2‐ethylhexyl)‐phthalate (DEHP) Chinese rare minnow ( Gobiocypris rarus ), an endemic distributed in upstream waters Yangtze River. Adult were exposed to environmentally relevant concentrations DEHP (0 µg/L, 3.6 12.8 39.4 and 117.6 µg/L) for a 21‐d period. Then, sex hormones plasma...
The potential neurotoxicity of polybrominated diphenyl ethers (PBDEs) is still a great concern. In the present study, authors investigated whether exposure to PBDEs could affect neurotransmitter system and cause developmental in zebrafish. Zebrafish embryos (2 h postfertilization) were exposed different concentrations PBDE mixture DE-71 (0-100 μg/L). larvae harvested at 120 postfertilization, impact on dopaminergic signaling was investigated. results revealed significant reductions content...