A5081491712- Acute Kidney Injury Research
- Extracellular vesicles in disease
- Renal and Vascular Pathologies
- Immune Response and Inflammation
- Corneal Surgery and Treatments
- Machine Learning and ELM
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects of Natural Compounds
- Galectins and Cancer Biology
- Cell Image Analysis Techniques
- MicroRNA in disease regulation
- RNA modifications and cancer
- Advanced Nanomaterials in Catalysis
- Ocular Surface and Contact Lens
- Digital Imaging for Blood Diseases
- Renal and related cancers
- Image Processing Techniques and Applications
- Healthcare and Venom Research
- Dialysis and Renal Disease Management
- Ferroptosis and cancer prognosis
- Single-cell and spatial transcriptomics
- Inflammatory Biomarkers in Disease Prognosis
- Traditional Chinese Medicine Studies
Chinese PLA General Hospital
2022-2025
Second Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2025
Nankai University
2025
Clemson University
2024
Xian Yang Central Hospital
2023
Jinshan Hospital of Fudan University
2023
Jingdezhen University
2023
State Key Laboratory of Kidney Diseases
2022
Chinese People's Liberation Army
2022
Abstract Background Renal fibrosis is a common pathological process of chronic kidney diseases induced by multiple factors. Hypoxic pretreatment mesenchymal stem cells can enhance the efficacy secreted extracellular vesicles (MSC-EVs) on various diseases, but it not clear whether they better improve renal fibrosis. The latest research showed that recovery fatty acid oxidation (FAO) reduce In this study, we aimed to examine hypoxic with MSC (Hypo-EVs) FAO restore and investigate underlying...
Understanding the acute kidney injury (AKI) microenvironment changes and complex cellular interaction is essential to elucidate mechanisms develop new targeted therapies for AKI.We employed unbiased single-cell RNA sequencing systematically resolve atlas of tissue samples from mice at 1, 2 3 days after ischemia-reperfusion AKI healthy control. The transcriptome findings were validated using multiplex immunostaining, western blotting, functional experiments.We constructed a systematic...
Abstract Dry eye disease (DED) is a prevalent inflammatory condition significantly impacting quality of life, yet lacks effective pharmacological therapies. Herein, we proposed novel approach to modulate the inflammation through metabolic remodeling, thus promoting dry recovery. Our study demonstrated that co-treatment with mesenchymal stem cells (MSCs) and thymosin beta-4 (Tβ4) yielded best therapeutic outcome against eye, surpassing monotherapy outcomes. In situ metabolomics...
Background: The disruption of mitochondrial homeostasis in acute kidney injury (AKI) is an important factor that drives persistent renal dysfunction. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have shown great therapeutic potential AKI, but insufficient specificity targeting the impaired function. Herein, we developed engineered nitric oxide (NO)-primed MSC-EVs (pEVs) to restore for AKI therapy. Methods: A cisplatin-induced model was established investigate effects...
Ischemic stroke (IS) ranks among the top causes of mortality and disability globally. Exosomes exert a crucial effect on maintaining complex regulatory balance with neuroinflammation in IS. Hence, this research aimed to elucidate roles exosome-related genes We integrated data from five IS-related datasets Gene Expression Omnibus (GEO) database ExoCarta. The least absolute shrinkage selection operator regression random forest models were performed detect feature genes. Search Tool for...
Background. Hepatocellular carcinoma (HCC) presents significant challenges in diagnosis and treatment. Understanding the role of PANoptosis-related molecules HCC is crucial for advancing therapeutic strategies. Methods. We conducted a comprehensive analysis using public data from Cancer Genome Atlas, Human Protein Tumor Immune Single Cell Hub, STRING databases. Techniques included Kaplan–Meier survival curves, Cox regression, LASSO analysis, various computational methods understanding tumor...
One of the most common techniques found in a cell biology or tissue engineering lab is cytotoxicity assay. This can be performed using variety different dyes and stains various protocols to result clear indication dead live cells within culture quantify viability monitor for sudden drops increases by drug, material, viral vector, etc introduced into culture. assay helps biologists determine health their what toxicity added substances may add whether they are appropriate safe use with human...
Acute kidney injury can be mitigated if detected early. There are limited biomarkers for predicting acute (AKI). In this study, we used public databases with machine learning algorithms to identify novel predict AKI. addition, the interaction between AKI and clear cell renal carcinoma (ccRCC) remain elusive.Four datasets (GSE126805, GSE139061, GSE30718, GSE90861) treated as discovery one (GSE43974) a validation dataset were downloaded from Gene Expression Omnibus (GEO) database....