A5101860587- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Animal Genetics and Reproduction
- Laser Material Processing Techniques
- Adaptive Control of Nonlinear Systems
- Advanced Photonic Communication Systems
- Additive Manufacturing Materials and Processes
- Iterative Learning Control Systems
- CRISPR and Genetic Engineering
- Optical Network Technologies
- Advanced Fiber Optic Sensors
- Photonic and Optical Devices
- Advanced machining processes and optimization
- Advanced Control Systems Optimization
- Injection Molding Process and Properties
- Semiconductor Lasers and Optical Devices
- Spectroscopy and Quantum Chemical Studies
- Hydraulic and Pneumatic Systems
- PI3K/AKT/mTOR signaling in cancer
- Additive Manufacturing and 3D Printing Technologies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Spectroscopy and Laser Applications
- Molecular Biology Techniques and Applications
- Advanced ceramic materials synthesis
- Cancer-related gene regulation
Aerospace Information Research Institute
2025
Clemson University
2020-2025
Weihai Science and Technology Bureau
2025
Harbin University of Science and Technology
2025
Yanshan University
2024
Fudan University
2017-2024
Center for Human Reproduction
2024
University of Medicine and Health Sciences
2024
Genomics (United Kingdom)
2024
Chongqing University
2024
Cadmium is a major environmental toxicant that released into the atmosphere, water and soil in form of cadmium oxide, chloride, or sulfide via industrial activities, such as manufacturing batteries pigments, metal smelting refining municipal waste incineration. In present study, we investigated effects exposure on sperm quality parameters, fertilization capacity early embryonic development. Our study showed vitro incubation human mouse sperms with for long time (up to 24 hours) could...
Early embryonic arrest is a challenge for in vitro fertilization (IVF). No genetic factors were previously revealed the sperm-derived of development. Here, we reported two infertile brothers presenting normal conventional semen analysis, but both couples had no embryos transfer after several IVF and intracytoplasmic sperm injection (ICSI). Whole-exome sequencing identified homozygous missense mutation ACTL7A brothers. This deleterious causes acrosomal ultrastructural defects. The Actl7a...
Abstract Predicting material’s microstructure under new processing conditions is essential in advanced manufacturing and materials science. This because the hugely influences properties. We demonstrate an elegant machine learning algorithm that faithfully predicts conditions, without need of knowing governing laws. name this algorithm, RCWGAN-GP, which regression-based conditional generative adversarial networks with Wasserstein loss function gradient penalty. was trained experimental SEM...
Before fertilization, sperms adhere to oviductal epithelium cells, and only a restrictive number of winner can escape reach the egg. To study sperm behavior from surface, we developed microfluidic chip fabricate an adhesive surface create gradient progesterone (P4) for mimicking oviduct microenvironment in vivo. We identified three motion patterns such microenvironment─anchored spin, run-and-spin, escaped mode. By using kinetic analysis, verified hypothesis that responsive rotation energy...
A novel dual-frequency two-dimensional infrared instrument is designed and built that permits three-pulse heterodyned echo measurements of any cross-peak within a spectral range from 800 to 4000 cm−1 be performed in fully automated fashion. The superior sensitivity the achieved by combination interferometry, phase cycling, closed-loop stabilization accurate ∼70 as. anharmonicity smaller than 10−4 was recorded for strong carbonyl stretching modes using laser shot accumulations. design scheme...
This study examined the relationship between eye-tracking speed and sight interpretation (SI) primarily through recording of eye-tracking-based target domain (TD) fixation. First, 9-point track calibration was created for a non-invasive investigation. Second, in less than 30[Formula: see text]s, participants finished SI output preheated materials, instructor assigned subjects 10 points based on standard, teacher scored according to standard (10 points). Finally, following eye rest, took...
High-temperature stress negatively affects the growth and development of plants, therefore threatens global agricultural safety. Cultivating stress-tolerant plants is current objective plant breeding programs. Pearl millet a multi-purpose plant, commonly used as forage but also an important food staple. This crop very heat-resistant has higher net assimilation rate than corn under high-temperature stress. However, response heat resistant pearl so far not been studied at transcriptional...
Predicting materials’ microstructure from the desired properties is critical for exploring new materials. Herein, a novel regression‐based prediction of scanning electron microscopy (SEM) images target hardness using generative adversarial networks (GANs) demonstrated. This article aims at generating realistic SEM micrographs, which contain rich features (e.g., grain and neck shapes, tortuosity, spatial configurations grain/pores). Together, these affect material but are difficult to...
In an effort to overcome the nonlinerities associated with a pneumatic system variable structure control (VSC) technique has been employed position of actuator. To accomplish this model actuator was developed allow systems be studied via simulations. The results from simulations indicated that VSC can rapidly, first-order trajectory, in response step input. An experimental study then performed. These experiments verified simulation work, and demonstrated inherent delays quantisation signals...
Abstract Background Actin-like 7 A (ACTL7A) is essential for acrosome formation, fertilization and early embryo development. ACTL7A variants cause detachment responsible male infertility embryonic arrest. In this study, we aim to explore the additional functions of beyond process biogenesis investigate possible underlying mechanisms. Methods Nuclear morphology analysis was used observe sperm head shape -mutated patients. Actl7a knock-out (KO) mouse model generated. Immunofluorescence...
A compact laser beam direction stabilization scheme is developed that provides the angular stability of better than 50 μrad over a wide range frequencies from 800 to 4000 cm-1. The schematic fully automated and features single MCT quadrant detector. was tested stabilize directions two IR beams used for dual-frequency two-dimensional infrared (2DIR) measurements showed excellent results: automatic tuning allowed achieving alignment quality within 10% optimal obtained manually. can be easily...
ABSTRACT Eukaryotic translation initiation factor 4E (eIF4E) mediates cap-dependent translation. Genetic and inhibitor studies show that eIF4E expression is required for the successful transition from maternal to embryonic control of mouse embryo development. was present in oocyte cytoplasm soon after fertilization during each stage early Functional knockout (Eif4e−/−) by PiggyBac [Act-RFP] transposition resulted peri-implantation lethality because failure normal epiblast formation. Maternal...
A microwave–photonic low-coherence interferometry (MPLCI) system is proposed for fully distributed optical fiber sensing. Assisted by an unbalanced Michelson interferometer, a laser source used to interrogate cascaded Fabry–Perot interferometers along with dark zone free (or spatially continuous) measurement. By combining the advantages of microwaves and photonics, MPLCI can synergistically achieve high sensitivity spatial resolution. Our tests have confirmed strain resolution 95 n <mml:math...
In this paper, an adaptive proportional-derivative (PD) plus sliding mode control (SMC) algorithm, APD-SMC in short, is proposed for tracking of robotic manipulators. The PD part used to bring the trajectory normalized tracking, SMC forces close surface, and estimate dynamics system. system has features with adaptation unknown stability analysis conducted based on Lyapunov theory, simulation study fulfilled comparisons are performed order prove effectiveness law.
LepR tyrosine site mutation mice (Y123F) exhibit decreased serum E2 levels, immature reproductive organs, infertility as well metabolic abnormalities. Although the actions of leptin and lepR in control function are thought to be exerted mainly via hypothalamic-pituitary-gonadal axis, relatively less is known regarding their local effects on peripheral ovary, especially steroid hormone synthesis. Meanwhile, whether fertility Y123F mouse could restored by gonadotropin has not been clear...
Human lifespan is considerably long, while mouse models can simulate the entire human in a relatively short period, with one year of life roughly equivalent to 40 years. Intracytoplasmic sperm injection (ICSI) commonly used assisted reproductive technology clinical practice. However, given its recent emergence about 30 years ago, long-term effects this technique on development remain unclear. In study, we established ICSI combined embryo transfer (ET) method using model. The results...
This paper proposed a robust H ∞ static output-feedback controller for the lane keeping of autonomous ground vehicles (AGVs) while environment/vehicle parameters are uncertain. The variations in vehicle mass, tire cornering stiffness, and steering ratio, which owing to model computational simplification, estimated firstly then handled as parameter uncertainties. Given expensive cost accessible equipment lateral data measurement, does not require accurate measurement mentioned above, was this...
It is shown that 30 Gb/s transmission over 40 km standard fibre of adaptively modulated optical OFDM signals feasible for directly DFB laser-based links without amplification and dispersion compensation. The corresponding loss margin >4 dB.