A5101461825- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive Biology and Fertility
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Family Caregiving in Mental Illness
- Assisted Reproductive Technology and Twin Pregnancy
- Dialysis and Renal Disease Management
- Metabolism, Diabetes, and Cancer
- Alzheimer's disease research and treatments
- Sleep and Wakefulness Research
- Folate and B Vitamins Research
- Radioactivity and Radon Measurements
- Restraint-Related Deaths
- SARS-CoV-2 and COVID-19 Research
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Viral gastroenteritis research and epidemiology
- Mast cells and histamine
- Ocular Infections and Treatments
- Traditional Chinese Medicine Studies
- Cancer-related cognitive impairment studies
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Genetics, Aging, and Longevity in Model Organisms
- Machine Learning in Healthcare
Hubei University of Chinese Medicine
2023-2025
Northeast Normal University
2025
Kunming Medical University
2024
Zhoushan Hospital
2024
Huazhong University of Science and Technology
2023-2024
Second Xiangya Hospital of Central South University
2023
Central South University
2023
Tongji Hospital
2023
Fudan University
2023
Obstetrics and Gynecology Hospital of Fudan University
2022
Ginsenoside Rg1 is the primary active substance in ginseng, and it has multiple pharmacological actions. Investigations on pharmacologic action of ginsenoside have developed, with a particular focus regulation metabolism. The present study hypothesized that neuroprotective effects prevent cognitive impairment induced by isoflurane anesthesia via antioxidant, anti‑inflammatory anti‑apoptotic effects, mediated phosphoinositide 3‑kinase (PI3K)/AKT/glycogen synthase kinase‑3β (GSK‑3β) pathway...
Standard methods for risk assessments resulting from human exposures to mixed radiation fields in Space consisting of different particle types and energies rely upon quality factors. These are generally defined as a function linear energy transfer (LET) assumed be proportional the risk. In this approach, it is further that risks single each add linearly. Although cancer acute photon radiations have been measured humans, factors protons ions heavier atomic mass inferred animal and/or cellular...
A dual-response (near-infrared, alternating magnetic field) multifunctional nanoplatform was developed based on urokinase plasminogen activators (uPA)-loaded metal–organic-framework (MOF)-derived carbon nanomaterials (referred to uPA@CFs below) for thrombolytic therapy. uPA loaded in mesoporous CFs could be released under the action of near-infrared (NIR)-mediated photothermy achieve superficial thrombolysis. More importantly, with assistance field (AMF), this system also precisely heat...
Introduction Existing evidence suggests an association between certain vitamins and metabolic syndrome (MetS), but few epidemiological studies have focused on the effects of multivitamin co-exposure MetS. This study aims to investigate associations individual or multiple water-soluble (i.e., vitamin C (VC), B9 (VB9), B12 (VB12)) with MetS, as well dose-response relationships among them. Methods A cross-sectional was conducted by employing National Health Examination Surveys (NHANESs)...
To explore the multiple mediating roles of learned helplessness's core system in relationship between health literacy/social support and self-management.Cross-sectional survey design.Changsha, China.239 Chinese maintenance haemodialysis (MHD) patients.Two mediator models were constructed based on COM-B (Capacity, Opportunity, Motivation - Behaviour) model. A total 239 MHD patients participated a cross-sectional study, which included surveys Learned Helplessness Scale for patients, Dialysis...
Purpose: Rapid developments are occurring in artificial intelligence (AI) and machine learning (ML) applied to neuroimaging. To date, advances this space have largely been limited research cohorts with little real-world translation that is clinically meaningful for patients psychiatry neurology those associated neuropsychiatric symptoms. There a lack of large multimodal linked datasets combining MRI imaging, clinical variables other biomarkers within more representative ethnically diverse...
SoxR, one of bacterial transcriptional regulators, plays a crucial role in responses to oxidative stress induced by unfavorable environmental conditions. So far, the understanding mainly stems from handful model bacteria such as Escherichia coli and studies on non-model are limited. In this study, Citrobacter braakii JPG1, commonly occurring strain enterobacteria, was used for first time explore SoxR aerobic/anaerobic-menadione stress. First, we analyzed phylogenetic relationship based whole...
The appearance of smooth endoplasmic reticulum aggregation (SERa) is one the most common dysmorphic phenotypes oocytes, however, impact SERa occurrence on in vitro fertilization (IVF) outcomes controversial. This study aimed to investigate oocytes aneuploidy subsequent embryos IVF.In this retrospective cohort study, a total 114 intracytoplasmic sperm injection (ICSI) cycles with undergoing preimplantation genetic testing for (PGT-A) were enrolled, and among them there 323 SERa(+) 1253...
Abstract Background Actin-like 7 A (ACTL7A) is essential for acrosome formation, fertilization and early embryo development. ACTL7A variants cause detachment responsible male infertility embryonic arrest. In this study, we aim to explore the additional functions of beyond process biogenesis investigate possible underlying mechanisms. Methods Nuclear morphology analysis was used observe sperm head shape -mutated patients. Actl7a knock-out (KO) mouse model generated. Immunofluorescence...
Islet transplantation is currently a promising treatment for type 1 diabetes mellitus. However, the foreign body reaction and retrieval difficulty often lead to failure hinder clinical application. To address these two challenges, we propose balanced charged sodium alginate–polyethyleneimine–melanin (SA–PEI–Melanin) threadlike hydrogel with immune shielding retrievable properties. The attractiveness of this study lies in that introduction melanin can stimulate insulin secretion, especially...
Obtaining high-quality embryos is one of the key factors to improve clinical pregnancy rate assisted reproductive technologies (ART). So far, evaluation embryo quality depends on morphology. However, still low. Therefore, new indicators are needed further quality. Several studies have shown that decrease sperm-specific protein actin-like 7A (ACTL7A) leaded low fertilization rate, poor development, and even infertility. The aim this study was whether different expression levels ACTL7A sperm...
Learned helplessness (LH) is an important concept in nursing. This study aimed to adapt and translate the Arthritis Helplessness Index scale into a Chinese version of LH for maintenance hemodialysis patients China (LHS-MHD-C), validate its psychometric properties. Data collected included LHS-MHD-C, as well Hospital Depression Scale (HADS-D), Beck Hopelessness (BHS) assessing LHS-MHD-C's criterion validity (predictive concurrent, respectively). The expert consultation pilot demonstrated...
Disability and even death from acute thrombosis remain a grave menace to public health. At present, the traditional drugs represented by urokinase (UK) in clinical thrombolysis can cause side effects of bleeding when dosage is excess. Therefore, more effective safer method urgently needed. In this paper, multifunctional dual-drug sequential release platform (UK-UH@PDA@HMSNs) consisting polydopamine (PDA)-modified hollow mesoporous silicon (HMSNs) loading with UK unfractionated heparin (UH)...
The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing, presenting a treatment challenge due to limited options. Endoplasmic reticulum (ER) stress and associated lipid metabolism disorders are main causes NAFLD, making it important inhibit ER for effective treatment. Fagopyrum dibotrys has hypolipidemic, anti-inflammatory hepatoprotective properties, showing promise in treating NAFLD. However, its effects on NAFLD remain unclear. This study used high-fat diet (HFD)...
This study investigated the etiology, clinical features, and management of acute hydrogen sulfide (H
Sleep deprivation impairs learning and memory. The neuroprotective function of ginsenoside Rg1 (Rg1) has been reported. This study aimed to investigate the alleviative effect underlying mechanism action on memory deficits induced by sleep deprivation. Using 72 h LED light establish model treatment with Rg1-L (0.5 mg/ml), Rg1-H (1 melatonin (positive control, 0.25 we investigated behavioral performance zebrafish through 24 autonomous movement tracking, a novel tank diving test, T-maze test....
Metabolic syndrome (MetS) is characterized by a group of metabolic disturbances which leads to the enhanced risk cancer development. Elucidating mechanisms between these two pathologies essential identify potential therapeutic molecular targets for colorectal (CRC). 716 patients from First and Second Affiliated Hospital Wenzhou Medical University were involved in our study disorders proven increase CRC. The prognostic value MetS factors was analyzed using Cox regression model clinical...
This study investigated the feasibility of using immunohistochemistry (IHC) instead PCR to detect BRAF V600E mutant protein in papillary thyroid carcinoma (PTC), and determine value preoperative by IHC assist diagnosis nodule patients with Hashimoto's thyroiditis (HT).The expression BRAFV600E was measured 23 cases HT+PTC, 31 PTC, 28 HT IHC, followed same samples for validation. SPSS 19.0 software used statistical analysis.The sensitivity specificity mutation were 100% 42.86%, respectively....
In spectral scene simulation applications, it is necessary to recognize and detect desert satellite images containing water. However, previous network models such as AlexNet, VggNet, GoogleNet have gradually fallen behind the trend of times. Compared with latest models, they not only slow training speeds but also do achieve high accuracy. Therefore, this study adopts a series solve problem compare analyze results.