A5003539242- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Venous Thromboembolism Diagnosis and Management
- Electrospun Nanofibers in Biomedical Applications
- Autophagy in Disease and Therapy
- Polymer Surface Interaction Studies
- RNA Research and Splicing
- Tissue Engineering and Regenerative Medicine
- Cardiac Ischemia and Reperfusion
- Endoplasmic Reticulum Stress and Disease
- Cardiac Fibrosis and Remodeling
- Advanced Polymer Synthesis and Characterization
- CRISPR and Genetic Engineering
- Nanoplatforms for cancer theranostics
- Mitochondrial Function and Pathology
- Cardiac Valve Diseases and Treatments
- ATP Synthase and ATPases Research
- Pluripotent Stem Cells Research
- Estrogen and related hormone effects
- Blood Coagulation and Thrombosis Mechanisms
- Peripheral Artery Disease Management
Nanchang University
2017-2025
Second Affiliated Hospital of Nanchang University
2017-2025
Second Affiliated Hospital of Zhejiang University
2015-2024
Guangzhou Medical University
2024
State Key Laboratory of Food Science and Technology
2022-2024
Shantou University
2013-2023
First Affiliated Hospital of Shantou University Medical College
2013-2023
Zhejiang University
2016-2023
Huzhou Women and Children's Hospital
2023
Jilin University
2020-2021
Abstract Our group recently reported positive therapeutic benefit of human endometrium-derived mesenchymal stem cells (EnMSCs) delivered to infarcted rat myocardium, an effect that correlated with enhanced secretion protective cytokines and growth factors compared parallel cultures bone marrow MSCs (BMMSCs). To define more precisely the molecular mechanisms EnMSC therapy, in present study, we assessed paracrine properties derived from endometrium, marrow, adipose tissues a model myocardial...
Rationale : Autophagy can preserve cell viability under conditions of mild ischemic stress by degrading damaged organelles for ATP production, but severe ischemia, it promote death and worsen cardiac performance. Mesenchymal stem cells (MSCs) are cardioprotective when tested in animal models myocardial infarction, whether these benefits occur through the regulation autophagy is unknown. Objective: To determine transplanted MSCs reduce rate autophagic degradation (autophagic flux) infarcted...
The effectiveness of transplanted bone marrow mesenchymal stem cells (MSCs) for cardiac repair has been limited; thus, strategies optimizing stem-cell-based myocardial therapy are needed.The present study was designed to test our central hypothesis that hypoxia-preconditioned MSCs (HP-MSCs) more effective than cultured under ambient oxygen levels the treatment injury in a large-scale (N=49), long-term (9 months), nonhuman primate (Cynomolgous monkeys) investigation.MSCs were engineered...
Bone marrow mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) have been widely used for treating myocardial infarction (MI). However, low retention and short-lived therapeutic effects are still significant challenges. This study aimed to determine whether incorporation of MSC-derived sEVs in alginate hydrogel increases their the heart thereby improving effects. Methods: The optimal sodium incorporating system was determined by its release ability rheology hydrogel. Ex...
Extracellular vesicles containing miR-486-5p augment angiogenesis after MI in mice and nonhuman primates by targeting fibroblastic Mmp19 .
Human pluripotent stem cell-derived cardiovascular progenitor cells (hPSC-CVPCs) should be thoroughly investigated in large animal studies before testing clinical trials.The main of this study is to clarify whether hPSC-CVPCs can engraft for long time the heart primates after myocardial infarction (MI) and compare effectiveness safety immunosuppression with cyclosporine alone or multiple-drug regimen (MDR) containing cyclosporine, methylprednisolone, basiliximab cynomolgus monkeys that had...
Mitochondria are important cellular organelles and play essential roles in maintaining cell structure function. Emerging evidence indicates that addition to having proinflammatory proapoptotic effects, TNFα (tumor necrosis factor α) can, under certain circumstances, promote improvements mitochondrial integrity function, phenomena can be ascribed the existence of TNFR2 (TNFα receptor 2).The present study aimed investigate whether how activation mediates effects on mitochondria.Freshly...
Ethnopharmacological relevance: Curcumin is a bright yellow chemical produced by plants of the Curcuma longa species. Chemically, curcumin diarylheptanoid, belonging to group curcuminoids. The therapeutic potential has been widely investigated, including its utilization in various cardiovascular diseases. However, effect cardiac remodeling post myocardial infarction and underlying mechanism remains be uncover. Aim: To evaluate on fibrosis after via macrophage-fibroblast crosstalk. Methods:...
Objective— Cigarette smoking is an independent risk factor for atherosclerosis. Nicotine, the addictive component of cigarettes, induces mast cell (MC) release and contributes to atherogenesis. The purpose this study was determine whether nicotine accelerates atherosclerosis through MC-mediated mechanisms MC stabilizer prevents pathological process. Approach Results— Nicotine administration increased size atherosclerotic lesions in apolipoprotein E–deficient ( Apoe −/− ) mice fed a...
Green tea catechins are known to function as anticancer agents via inhibition of carcinogenesis during the initiation, promotion and progression stages. Many potential mechanisms have been proposed, yet precise mechanism lung cancer prevention by green remains unclear. microRNAs (miRs) a class 21-24 nucleotide small non-coding RNAs play critical roles throughout cellular development regulation. Emerging evidence demonstrates that influence expression miRs in human cells inhibit...
Abstract Background The effect of lncRNA FTX on non-alcoholic fatty liver disease (NAFLD) conversion to hepatocellular carcinoma (HCC) is unclear. Methods In our study, C57BL/6 mice was fed with high fat diet for obtaining NAFLD mouse model, and diethylnitrosamine induced the formation HCC tumor. expression iNOS CD206 in tissues were examined using immunohistochemistry. addition, qRT-PCR implemented detect mRNAs. percentage M1 M2 Kupffer cells (KCs) determined flow cytometry. pathological...
Background: Cardiac fibrosis is a common pathological feature associated with adverse clinical outcome in postinjury remodeling and has no effective therapy. Using an unbiased transcriptome analysis, we identified FMO2 (flavin-containing monooxygenase 2) as top-ranked gene dynamically expressed following myocardial infarction (MI) hearts across different species including rodents, nonhuman primates, human. However, the functional role of cardiac largely unknown. Methods: Single-nuclei...
A dual-response (near-infrared, alternating magnetic field) multifunctional nanoplatform was developed based on urokinase plasminogen activators (uPA)-loaded metal–organic-framework (MOF)-derived carbon nanomaterials (referred to uPA@CFs below) for thrombolytic therapy. uPA loaded in mesoporous CFs could be released under the action of near-infrared (NIR)-mediated photothermy achieve superficial thrombolysis. More importantly, with assistance field (AMF), this system also precisely heat...
Thromboembolism is the leading cause of cardiovascular mortality. Currently, for lack targeting, short half-life, low bioavailability and high bleeding risk classical thrombolytic drugs, pharmacological thrombolysis usually a slow process based on micro-pumping. In addition, frequently monitoring regulating coagulation functions are also required during (and after) thrombolysis. To address these issues, targeted anticoagulation nanoplatform (UCATS-UK) developed upconversion nanoparticles...
MicroRNAs (miRNAs) and DNA mismatch repair (MMR) have been linked to human cancer progression. Human mutL homolog 1 (hMLH1), one of the core MMR genes, defects in lung development. However, interaction between miRNAs genes their regulatory effect on cell cycle remain poorly understood. In this study, we investigated role miR-31-5p hMLH1 gene expression non-small (NSCLC). We found that was inversely correlated with NSCLC lines a direct target miR-31-5p. Knockdown induced arrest at G2/M phase...
Angiogenesis is essential for vascular development. The roles of regulatory long noncoding RNAs (lncRNAs) in mediating angiogenesis remain under-explored. Human embryonic stem cell-derived mesenchymal cells (hES-MSCs) are shown to exert more potent cardioprotective effects against cardiac ischemia than human bone marrow-derived MSCs (hBM-MSCs), associated with enhanced neovascularization. purpose this study search angiogenic lncRNAs enriched hES-MSCs, and investigate their mechanisms....
Coarctation of the aorta is a congenital cardiovascular anomaly characterized by aortic narrowing, typically presenting in early life. This report describes an exceptionally rare case severe abdominal coarctation with extensive collateral vessel formation asymptomatic 80-year-old male, underscoring importance recognizing delayed presentations and compensatory mechanisms. narrowing significant dilatation visceral arteries elderly along review pertinent literature. An Han Chinese male 10-year...
Malignant glioma is one of the most common types primary malignancies in human central nervous system. Temozolomide (TMZ) commonly used drug clinical therapy glioma; however, chemoresistance makes difficult to cure and relapse likely. Sirtuin 1 (SIRT1) serves important roles cell proliferation, differentiation metabolism, but role SIRT1 remains largely unexplored. In present study, expression was assessed tissues cells. RNA interference inhibitor were determine effect on growth inhibition...
A better understanding of the molecular mechanism aortic valve development and bicuspid (BAV) formation would significantly improve optimize therapeutic strategy for BAV treatment. Over past decade, genes involved in have been increasingly recognized. On other hand,