A5086811460- Head and Neck Cancer Studies
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Viral Infectious Diseases and Gene Expression in Insects
- CAR-T cell therapy research
- Colorectal and Anal Carcinomas
- Silicon Carbide Semiconductor Technologies
- Cancer Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Molecular Biology Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advancements in Semiconductor Devices and Circuit Design
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Gastric Cancer Management and Outcomes
- Bone fractures and treatments
- Infant Nutrition and Health
- Lung Cancer Treatments and Mutations
- Chronic Myeloid Leukemia Treatments
- Neonatal Respiratory Health Research
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- COVID-19 Clinical Research Studies
- Fetal and Pediatric Neurological Disorders
- Viral-associated cancers and disorders
St. Jude Children's Research Hospital
2021-2023
The University of Texas MD Anderson Cancer Center
2006-2022
Gujarat Cancer Society
1993
Current chimeric antigen receptor-modified (CAR) T-cell products are evaluated in bulk, without assessing functional heterogeneity. We therefore generated a comprehensive single-cell gene expression and receptor (TCR) sequencing data set using pre- postinfusion CD19-CAR T cells from blood bone marrow samples of pediatric patients with B-cell acute lymphoblastic leukemia. identified cytotoxic identical TCRs to subset preinfusion CAR cells. These effector precursor exhibited unique...
Abstract Purpose: Development of extranodal extension (ENE) has been associated with poor survival in patients oral cavity squamous cell carcinoma (OSCC). Here, we sought to confirm the role ENE as a prognostic factor, and identify genomic epigenetic markers order develop predictive model improve treatment selection. Experimental Design: An institutional cohort (The University Texas MD Anderson Cancer Center) was utilized impact on clinical outcomes evaluate signature primary containing...
Although mRNA vaccine efficacy against severe COVID-19 remains high, variant emergence and breakthrough infections have changed policy to include booster immunizations. However, the effect of diverse repeated antigen exposures on SARS-CoV-2 memory T cells is poorly understood. Here, we utilize DNA-barcoded MHC-multimers combined with scRNAseq scTCRseq capture ex vivo profile SARS-CoV-2-responsive within a cohort individuals one, two, or three exposures, including vaccination, primary...
BACKGROUND Human immunodeficiency virus–infected individuals (HIVIIs) have a higher incidence of head and neck squamous cell carcinoma (HNSCC), clinical histopathological differences been observed in their tumors comparison with those HNSCC patients without human virus (HIV) infection. The reasons for these are not clear, molecular between HIV‐related non–HIV‐related may exist. This study compared the mutational patterns HNSCC. METHODS DNA 20 samples HNSCCs 32 was sequenced. libraries...
Background: Multimodality treatment of head and neck cancer in rural India is not always feasible due to lack infrastructure logistics. Aim: To demonstrate the feasibility multimodality for a community setting India. Setting Design: Community center, retrospective review. Materials Methods: This article focuses on practice environment clinic We evaluated patient profile, protocols, availability, factors impacting decisions, cost estimations, completion treatment, major treatment-related...
Microbial components have a range of direct effects on the fetal brain. However, little is known about cellular targets and molecular mechanisms that mediate these effects. Neural progenitor cells (NPCs) control size architecture brain understanding regulating NPCs crucial to developmental disorders. We identify ventricular radial glia (vRG), primary NPC, as target bacterial cell wall (BCW) generated during antibiotic treatment maternal pneumonia. BCW enhanced proliferative potential vRGs by...
An evolutionary action scoring algorithm (EAp53) based on phylogenetic sequence variations stratifies patients with head and neck squamous cell carcinoma (HNSCC) bearing TP53 missense mutations as high-risk, associated poor outcomes, or low-risk, similar outcomes wild-type, has been validated a reliable prognostic marker. We performed this study to further validate prior findings demonstrating that EAp53 is marker for locally advanced HNSCC explored its predictive value treatment adjuvant...
6010 Background: An evolutionary action scoring algorithm (EAp53) based on phylogenetic sequence variations and speciation stratifies head neck squamous cell carcinoma (HNSCC) patients bearing TP53 missense mutations as high-risk (high, EAp53≥75), associated with poor outcomes, or low-risk (low), similar outcomes wild-type (wt), has been validated a reliable prognostic marker. This study is designed to further validate prior findings that EAp53 marker for locally advanced HNSCC patients,...
4011 Background: GBC and BDC (BTC) are uncommon in the United States, but endemic parts of South America Asia. BTC aggressive tumors with poor survival rates. Chemotherapy RR is <30%, no benefit has been demonstrated. Improved understanding molecular carcinogenic mechanisms may lead to improved therapeutic regimens. Activation HER-2/neu play a prominent role development breast cancer. In this study, patient (pt) specimens from U.S., Chile, Japan were examined immunohistochemical (IHC)...
Abstract Current chimeric antigen receptor-modified (CAR) T cell therapy products are evaluated in bulk, without assessment of the possible heterogeneity effector potential between cells. Conceivably, only a subset pre-infusion product differentiates into optimal effectors. We generated comprehensive single-cell gene expression and receptor (TCR) sequencing dataset using both pre- post-infusion CD19-CAR cells from peripheral blood bone marrow pediatric patients with B acute lymphoblastic...
Peripheral blood samples from 55 previously untreated leukemia patients (33 males, 22 females) were analysed for terminal deoxynucleotidyl transferase (TdT) activity. TdT was significantly higher in with acute myelogenous (AML; P < 0.001), chronic (CML; 0.05) and lymphoblastic (ALL; 0.001) when compared controls. One patient lymphocytic (CLL) had undetectable TdT. Among leukemic patients, ALL concentration of than CML AML patients. Females activity although the difference between two groups...
Figure S1 from High-Risk <i>TP53</i> Mutations Are Associated with Extranodal Extension in Oral Cavity Squamous Cell Carcinoma
Supplementary Figure and Table Legends from High-Risk <i>TP53</i> Mutations Are Associated with Extranodal Extension in Oral Cavity Squamous Cell Carcinoma
Figure S1 from High-Risk <i>TP53</i> Mutations Are Associated with Extranodal Extension in Oral Cavity Squamous Cell Carcinoma
Table S6 from High-Risk <i>TP53</i> Mutations Are Associated with Extranodal Extension in Oral Cavity Squamous Cell Carcinoma
Table S5 from High-Risk <i>TP53</i> Mutations Are Associated with Extranodal Extension in Oral Cavity Squamous Cell Carcinoma
Table S4 from High-Risk <i>TP53</i> Mutations Are Associated with Extranodal Extension in Oral Cavity Squamous Cell Carcinoma
Table S9 from High-Risk <i>TP53</i> Mutations Are Associated with Extranodal Extension in Oral Cavity Squamous Cell Carcinoma
Figure S2 from High-Risk <i>TP53</i> Mutations Are Associated with Extranodal Extension in Oral Cavity Squamous Cell Carcinoma
Table S2 from High-Risk <i>TP53</i> Mutations Are Associated with Extranodal Extension in Oral Cavity Squamous Cell Carcinoma
Table S7 from High-Risk <i>TP53</i> Mutations Are Associated with Extranodal Extension in Oral Cavity Squamous Cell Carcinoma
<p>Supp Table 3</p>
Table S8 from High-Risk <i>TP53</i> Mutations Are Associated with Extranodal Extension in Oral Cavity Squamous Cell Carcinoma