Sean Cherry
A5055933085- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Animal Disease Management and Epidemiology
- Animal Virus Infections Studies
- COVID-19 epidemiological studies
- interferon and immune responses
- SARS-CoV-2 detection and testing
- Viral Infections and Outbreaks Research
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Diabetes and associated disorders
- Antimicrobial Resistance in Staphylococcus
- Virus-based gene therapy research
- Viral Infections and Vectors
- Bacterial Infections and Vaccines
- Bat Biology and Ecology Studies
- Immunotherapy and Immune Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Pneumonia and Respiratory Infections
- Immune Response and Inflammation
- Neonatal Respiratory Health Research
St. Jude Children's Research Hospital
2017-2025
Centers for Disease Control and Prevention
2020
University of Chile
2020
SARS-CoV-2 infection causes diverse outcomes ranging from asymptomatic to respiratory distress and death. A major unresolved question is whether prior immunity endemic, human common cold coronaviruses (hCCCoVs) impacts susceptibility or following vaccination. Therefore, we analyzed samples the same individuals before after We found hCCCoV antibody levels increase exposure, demonstrating cross-reactivity. However, a case-control study indicates that baseline are not associated with protection...
Bacteria growing within biofilms are protected from antibiotics and the immune system. Within these structures, horizontal transfer of genes encoding virulence factors promoting antibiotic resistance occurs, making an extremely important aspect pneumococcal colonization persistence. Identifying environmental cues that contribute to formation is critical understanding infection. It has been shown iron essential for biofilms; however, role other physiologically metals such as copper, zinc,...
The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify that may pose a human public health risk. Since 1999, canine H3 viruses (CIVs) have caused many thousands or millions respiratory infections in dogs United States. While no with CIVs been reported date, these could zoonotic In studies, National Institutes Allergy Infectious Diseases (NIAID) Centers Excellence Influenza Research Surveillance...
Abstract SARS-CoV-2 has caused millions of infections worldwide since its emergence in 2019. Understanding how infection and vaccination induce mucosal immune responses they fluctuate over time is important, especially are key preventing reducing disease severity. We established a novel methodology for assessing cytokine antibody at the nasal epithelium by using nasopharyngeal swabs collected longitudinally before after either or vaccination. then compared between systemic compartments....
Abstract Zoonotic transmission of avian influenza viruses into mammals is relatively rare due to anatomical differences in the respiratory tract between species. Recently, clade 2.3.4.4b highly pathogenic H5N1 were detected circulating North American cattle. Sporadic cattle, humans, and other animals proximal cattle or after consuming products from infected has occurred, but thus far there no evidence human-to-human transmission. However, virus potential adapt mammalian with every event that...
Hemagglutinin (HA) stability, or the pH at which HA is activated to cause membrane fusion, has been associated with replication, pathogenicity, transmissibility, and interspecies adaptation of influenza A viruses. Here, we investigated mechanisms by a destabilizing mutation, Y17H (activation pH, 6.0), attenuates virus replication pathogenicity in DBA/2 mice compared wild-type (WT) 5.5). The extracellular lung was measured be near neutral (pH 6.9 7.5). WT viruses had similar environmental...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and has since caused a global pandemic resulting millions of cases deaths. Diagnostic tools serological assays are critical for controlling the outbreak, especially designed to quantitate neutralizing antibody levels, considered best correlate protection. As vaccines become increasingly available, it is important identify reliable methods measuring responses that with authentic virus neutralization but can be...
Influenza virus isolation from clinical samples is critical for the identification and characterization of circulating emerging viruses. Yet efficient can be difficult. In these studies, we isolated primary swine nasal tracheal respiratory epithelial cells immortalized (siNEC) (siTEC) that retained abilities to form tight junctions cilia differentiate at air-liquid interface like cells. Critically, both human influenza viruses replicated in cells, which generally yielded higher-titer viral...
The efficacy of coronavirus disease 2019 (COVID-19) vaccines administered after COVID-19-specific monoclonal antibody is unknown, and "antibody interference" might hinder immune responses leading to vaccine failure. In an institutional review board-approved prospective study, we found that individual who received mRNA COVID-19 vaccination <40 days therapy for symptomatic had similar postvaccine SARS-CoV-2 receptor binding domain (RBD) 4 important variants (B.1, B.1.1.7, B.1.351, P.1) as...
Following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or vaccination there is significant variability between individuals in protective antibody levels against SARS-CoV-2, and within different virus variants. However, host demographic clinical characteristics that predict cross-reactive are not well-described. These data could inform clinicians, researchers, policymakers on the populations most likely to require vaccine booster shots.In an institutional review...
Swine influenza virus (SIV) can cause respiratory illness in swine. contribute to reassortment, as avian, human, and/or swine viruses infect and reassort, new emerge. Thus, it is important determine the host antiviral responses that affect SIV replication. In this study, we examined innate cytokine response by epithelial cells, focusing on expression of interferon (IFN) interferon-stimulated genes (ISGs). Both primary transformed nasal tracheal cells were following infection with field...
Abstract Since their discovery in the United States 1963, outbreaks of infection with equine influenza virus (H3N8) have been associated serious respiratory disease horses worldwide. Genomic analysis suggests that H3 viruses are an avian lineage, likely originating wild birds. Equine-like internal genes identified isolated from birds Southern Cone South America. However, equine-like hemagglutinin has not identified. We 6 distinct Chile hemagglutinin, nucleoprotein, nonstructural protein 1,...
ABSTRACT Hemagglutinin (HA) stability, or the pH at which HA is activated to cause membrane fusion, has been associated with replicative fitness, pathogenicity, transmissibility, and interspecies adaptation of influenza A viruses. Here, we investigated several mechanisms by a destabilizing mutation, Y17H (activation 6.0), may attenuate virus replication pathogenicity in DBA/2 mice, compared wild-type (WT; activation 5.5). Extracellular lung was measured be near neutral (pH 6.9–7.5). WT...
Abstract Persons with obesity are at higher risk for developing severe complications upon influenza virus infection making vaccination a priority. Yet, studies demonstrate vaccine responses less effective in obese hosts. In these studies, we examined how the timing of weight loss influenced efficacy male and female diet- induced mice. Here, show post-vaccination is insufficient to rescue poor efficacy; however, occurring pre-vaccination successfully improves outcomes viral challenge....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and has since caused a global pandemic resulting millions of cases deaths 1-4 . Diagnostic tools serological assays are critical for controlling the outbreak 5-7 , especially designed to quantitate neutralizing antibody levels, considered best correlate protection 8-11 As vaccines become increasingly available 12 it is important identify reliable methods measuring responses that with authentic virus...
Abstract Pregnant women and infants are considered high-risk groups for increased influenza disease severity. While virus vaccines recommended during pregnancy, cannot be vaccinated until at least six months of age. Passive transfer maternal antibodies (matAbs) becomes vital the infant’s protection. Here, we employed an ultrasound-based timed-pregnancy murine model examined matAb responses to distinct vaccine platforms A (IAV) infection in dams their offspring. We demonstrate vaccinating...
The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify that may pose a human public health risk. Since 1999, canine H3 viruses (CIVs) have caused many thousands or millions respiratory infections in dogs United States. While no with CIVs been reported date, these could zoonotic In studies, National Institutes Allergy Infectious Diseases (NIAID) Centers Excellence Influenza Research Surveillance...