A5076222222- Hepatitis C virus research
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Lipid metabolism and disorders
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- Natural Compounds in Disease Treatment
- Whipple's Disease and Interleukins
- Ginseng Biological Effects and Applications
- IL-33, ST2, and ILC Pathways
- Cancer Genomics and Diagnostics
- Diabetes and associated disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammasome and immune disorders
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
Second Affiliated Hospital of Harbin Medical University
2014-2024
Harbin Medical University
2014-2024
Chinese Academy of Agricultural Sciences
2024
Institute of Special Animal and Plant Sciences
2024
Air Force Medical University
2024
Xijing Hospital
2024
Northeast Agricultural University
2022
Sheng Jing Hospital
2021
Zhejiang University
2021
Fudan University
2020
Caffeic acid O-methyltransferase (COMT) is one of the core enzymes involved in lignin synthesis. However, there no systematic study on rice COMT gene family. We identified 33 genes containing methyltransferase-2 domain genome using bioinformatic methods and divided them into Group I (a b) II. Motifs, conserved domains, structure SNPs density are related to classification OsCOMTs. The tandem phenomenon plays a key role expansion expression levels fourteen thirteen OsCOMTs increased or...
Breast cancer (BC) is the most common cause of death in women throughout world. MicroRNAs (miRNAs, miR) have been identified as key regulators carcinogenesis several cancers, including BC. MicroRNA-216a (miR-216a) downregulated cancers. Here, we evaluated effects miRNA-216a on breast cells and underlying mechanisms. miR-216a level was quantified by real-time RT-PCR. Cell viability analyzed MTT assay. Wound-healing assay performed for detection cell migration. Apoptosis detected TUNEL...
Globally, colorectal cancer (CC) is the third leading cause of mortality associated with cancer. Natural killer (NK) cells are a major class that responsible for eliminating tumor and cytokine production. NK cell-mediated production interferon gamma (IFN-γ) has antiviral, immunoregulatory anti-tumor properties. IL-15 important in linking inflammation For instance, promotes humoral immune responses to inhibit growth. inhibits colitis-associated colon carcinogenesis by inducing antitumor...
DEP domain containing 1 ( DEPDC 1) protein is a novel oncoantigen upregulated in multiple types of cancers which present oncogenic activity and high immunogenicity. However, the function therapeutic potential hepatocellular carcinoma HCC ) remain unclear. In study, we showed that was frequently associated with cancer diagnosis poor prognosis for patients. Moreover, promotes cell proliferation vitro as well carcinogenesis vivo. Notably, overexpression also increases neoplasm metastasis...
Hepatocellular carcinoma (HCC) is highly aggressive with a poor prognosis and survival rate. Certain ANGPTL members have been implicated in tumor progression. However, the relevance of gene family to HCC remains poorly understood. In this study, we explored role ANGPTLs HCC.From CCLE database, studied expression range cancer cell lines. The UCSC, HCCDB, Human Protein Atlas databases were used analyze differences mRNA protein tissues. Additionally, correlation between methylation levels...
The relationship between hepatitis C virus (HCV) genotypes and antibody status was studied in 104 chronic non-A, non-B patients asymptomatic HCV-infected blood donors. On the basis of amplification nonstructural protein 3 (NS3) coding region by PCR hybridization with specific probes, 55 42 were identified as being infected type I II, respectively, according to classification H. Okamoto, K. Kurai, S. Okada, Yamamoto, Lizuka, T. Tanaka, Fukuda, F. Tsudaand, Mishiro (Virology 188:331-341,...
Background and Objective . A reliable noninvasive prediction tool for the screening, diagnosis, and/or staging of colorectal cancer (CRC) before surgery is critical choice treatment prognosis. Methods Patients admitted initial CRC between January 1, 2015, December 31, 2018, were retrieved reviewed. Records CD16+CD56+ natural killer (NK) cells analyzed according to stages CRC. Results The number qualified participants in healthy, stage I, II, III, IV patients 60, 66, 70, 68, respectively....
Cytokine-induced apoptosis inhibitor 1 (CIAPIN1), originally termed anamorsin, is an anti-apoptotic molecule that acts as a downstream effector of the receptor tyrosine kinase-Ras signaling pathway. Overexpression CIAPIN1 contributes to multidrug resistance (MDR) and microRNA (miR)-143 typically considered tumor suppressor in breast cancer. The present study aimed evaluate therapeutic potential miR-143 treatment for drug-resistant cancer via downregulation vitro. expression levels were...
The utilization of immune checkpoint inhibitors in oncological treatment has increased recent years. therapeutic strategy targeting the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway altered management advanced non-small cell lung carcinoma (NSCLC). Tislelizumab, a novel anti-PD-1 monoclonal antibody developed China, demonstrated efficacy treating NSCLC. However, its potential role as neoadjuvant therapy for locally NSCLC not been definitively established. Current...
To determine the tumoricidal ability of combined immunotherapy natural killer (NK) cells and dendritic (DCs) in a melanoma mouse model functions tumor-associated effector cells.A C57BL/6 subcutaneous lung metastasis was established. NK DCs were cultured labeled vitro. Varying frequencies both adoptively transferred into tumor-bearing mice. Tumor, liver, spleen, studied for number distribution cells. Additionally, CD8+T cell numbers metastatic nodules determined.Co-culture might maintain...
Acute myocardial infarction (AMI) has been a devastating actuality and accounts for half of cardiovascular emergency department visits. Nucleotide oligomerization domain, leucine-rich repeat, pyrin domain-containing protein 3 (NLRP3) inflammasome participates in the mediation inflammation during AMI. Therefore, this study aimed to reveal therapeutic function tranilast, an agent targeting NLRP3, AMI mouse model was first established by transient ischemia. Western blot quantitative reverse...
Introduction Acetyl-CoA synthetase 2 (ACSS2), one of the enzymes that catalyze conversion acetate to acetyl-CoA, has been proved be an oncogene in various cancers. However, function ACSS2 is still largely a black box melanoma. Methods The expression was detected melanoma cells and melanocytes at both protein mRNA levels. Cell viability, apoptosis, migration invasion were investigated after knockdown. RNA sequencing (RNA-Seq) technology employed identify differentially expressed genes caused...
Abstract The pandemic of COVID-19 caused by SARS-CoV-2 has posed serious threats to global health and economy, thus calling for the development safe effective vaccines. receptor-binding domain (RBD) in spike protein is responsible its binding ACE2 receptor. It contains multiple dominant neutralizing epitopes serves as an important antigen Here, we showed that immunization mice with a candidate subunit vaccine consisting RBD Fc fragment human IgG, immunopotentiator, elicited high titer...
Objective To predict and select the targeting miRNA highly matched 3'untranslated region(3'UTR) of cytokine induced apoptosis inhibitor1 (CIAPIN1) gene, to primarily investigate correlation between CIAPIN1 target in parental cell lines drug-resistant breast cancer. Methods The potentially binding seed side 3'-UTR was predicted by bioinformatics software as well screening out according literatures TargetScan, PicTarmi miRanda. The expression protein resistant cancer detected using...