A5045933130- Electromagnetic Fields and Biological Effects
- 3D Printing in Biomedical Research
- Advanced Chemical Sensor Technologies
- Cancer Research and Treatments
- Multicomponent Synthesis of Heterocycles
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Metal complexes synthesis and properties
- Radiomics and Machine Learning in Medical Imaging
- Advanced biosensing and bioanalysis techniques
- Microbial Inactivation Methods
- SARS-CoV-2 and COVID-19 Research
- Plant Toxicity and Pharmacological Properties
- Nuts composition and effects
- Electrochemical sensors and biosensors
- Respiratory viral infections research
- Plant-Derived Bioactive Compounds
- bioluminescence and chemiluminescence research
- Maritime Transport Emissions and Efficiency
- Medical Imaging Techniques and Applications
- Infrared Thermography in Medicine
- COVID-19 and healthcare impacts
- Breast Cancer Treatment Studies
- Ferrocene Chemistry and Applications
- Synthesis and Characterization of Pyrroles
Motamed Cancer Institute
2017-2024
Academic Center for Education, Culture and Research
2017-2024
University of Tehran
2024
Cancer Research Center
2020
Bu-Ali Sina University
2018
Pasteur Institute of Iran
2012-2015
Abstract Background High morbidity and mortality rates of the COVID-19 pandemic have made it a global health priority. Acute respiratory distress syndrome (ARDS) is one most important causes death in patients. Mesenchymal stem cells been subject many clinical trials for treatment ARDS because their immunomodulatory, anti-inflammatory, regenerative potentials. The aim this phase I trial was safety assessment allogeneic placenta-derived mesenchymal (PL-MSCs) intravenous injection patients with...
Wound healing of burned skin remains a major goal in public health. Previous reports showed that the bone marrow stem cells were potent keratinization and vascularization full thickness wounds.In this study, mesenchymal derived from rat adipose tissues characterized by flowcytometry. Staining methods used to evaluate their differentiation ability. A collagen-chitosan scaffold was prepared freeze-drying method crosslinked carbodiimide-based crosslinker.The results immunecytochemistry PCR...
Abstract Objectives To evaluate anti‐proliferative as well apoptotic activities of compounds identified in chloroform extract Juglans regia leaves, on human breast and oral cancer cell lines ( MCF ‐7 BHY ). Materials methods Column chromatography, MTT assay, flowcytometry western blotting have all been used the study. Results Bioassay‐guided fractionation J. afforded isolation 5‐hydroxy‐3,7,4′‐trimethoxyflavone [ 1 ], lupeol 2 daucosterol 3 4‐hydroxy‐α ‐ tetralone 4 β‐sitosterol 5 5,7‐...
Detecting the micrometastasis is a major challenge in patients' survival. The small volume of biopsied tissue results limited number histopathological samples and might reduce rate accurate diagnosis even by molecular technologies. We introduce microelectronic biochip (named Metas-Chip) to detect unprocessed liquid or solid samples. It works based on tendency malignant cells track single human umbilical vein endothelial cell (HUVEC)-sensing traps. Such detach themselves from sample invade...
Abstract Background NK cells are the most active innate immune in antiviral immunity, which impaired by SARS-COV2 infection. Infusion of allogeneic might be a complementary treatment to boost system function COVID-19 patients. In this project, we focused on patients with low inspiratory capacity (LIC). This project aims evaluate feasibility and safety cell infusion as an intervention for respiratory viral disease. Methods A non-blind two arms pilot study was designed conducted after signing...
Since organotin complexes have been reported to show fewer side effects relative other heavy metal anticancer compounds, in the present study we report for first time four novel organotin(IV) derivatives with general formula R 2 SnL , where = methyl (1), n ‐butyl (2), phenyl (3), benzyl (4) and L morpholine‐1‐carbodithioate (MCDT). The newly synthesized ligand was monodentate or bidentate, coordinating through a sulfur atom. were by directly mixing, refluxing stirring ligand, diorganotin(IV)...
Abstract Background We discovered that pure positive electrostatic charges (PECs) have an intrinsic suppressive effect on the proliferation and metabolism of invasive cancer cells (cell lines animal models) without affecting normal tissues. Methods interacted cell tumors with PECs by connecting a charged patch to tumors. many biochemical, molecular radiological assays were carried out PEC treated control samples. Results Correlative interactions between contain critical unknown factors...
Centaurea bruguierana subsp. belangerana was extracted by 80% ethanol. The total extract then partitioned into four fractions including chloroform, ethyl acetate and methanol. Cytotoxic effect of examined MTT assay in K562 (chronic myelogenous leukemia), AGS (gastric adenocarcinoma), MCF-7 (breast adenocarcinoma) SW742 (colon cell lines. Chloroform fraction, with the lowest LC50 against K-562 lines, 14 subfractions subjected to further purification reversed-phase (C18) silica gel sephadex...
For most people, the first step in treatment is to take out tumor (surgery), so precise and fast diagnosis of any sign high-risk neoplastic cells, especially surgical cavity margins, significant. The frozen pathology method conventional standard intraoperative diagnosis, but low number slides prepared from non-fixed tissues prevents us achieving a perfect diagnosis. Although many improvements margin detection were achieved, still real-time lesions crucial improving diagnostic quality....
Abstract Background Cancer diagnostic probe (CDP) had been developed to detect involved breast cavity side margins in real‐time (Miripour et al. Bioeng Transl Med. e10236.). Here, we presented the results of vivo human model CDP studies on non‐neoadjuvant cases. Methods This study is a prospective, blind comparison gold standard, and medical group recruited patients. frozen data were achieved before permanent pathology experiment. The main outcome surgical margin status. From November 2018...
Effect of Extremely Low–frequency Electromagnetic Field on Apoptosis Induction and Expression Estrogen Receptor, Progesterone ERBB2 in BT-474 Cells
Substituted pyrroles are an essential class of heterocyclic compounds. In this research, efficient and eco-friendly method has been developed for the synthesis pyrrole derivatives from reaction 2,5-hexanedione primary amines. Magnetic nanoparticles supported on functionalized. 7-aminonaphthalene-1,3-disulfonic acid-functionalized. silica (Fe3O4@SiO2@Propyl–ANDSA) investigated as a novel catalyst in reaction. Herein, was environmentally friendly excellent yields. It should also be noted that...