A5101860302- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- Economic and Financial Impacts of Cancer
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Multiple and Secondary Primary Cancers
- Cardiovascular and exercise physiology
- Inflammatory Biomarkers in Disease Prognosis
- Urinary and Genital Oncology Studies
- Veterinary Oncology Research
- Head and Neck Surgical Oncology
- Heart Rate Variability and Autonomic Control
- Cancer Cells and Metastasis
- Blood Pressure and Hypertension Studies
- 3D Printing in Biomedical Research
- Galectins and Cancer Biology
- Macrophage Migration Inhibitory Factor
- Balance, Gait, and Falls Prevention
- Autoimmune Bullous Skin Diseases
- Systemic Sclerosis and Related Diseases
- Cardiac Health and Mental Health
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
Tokyo Women's Medical University Adachi Medical Center
2022-2025
Tokyo Women's Medical University
2021-2025
Jyoban Hospital
2024-2025
Tohoku Rosai Hospital
2015-2024
Noguchi Hospital
2021-2022
Saiseikai Fukuoka General Hospital
2021
Azabu University
2011-2019
Kansai University of Welfare Sciences
2016
Kumamoto Health Science University
2016
Kumamoto University
2016
Background/Aim: We investigated the prognostic nutritional index (PNI), comprised of lymphocytes and albumin, as a potential prognosticator metastatic urothelial carcinoma (mUC) patients receiving pembrolizumab. Patients Methods: Sixty-five were retrospectively enrolled classified low (<40) high (≥40) based on pretreatment PNI. Progression-free survival (PFS), overall (OS) response rates evaluated. Results: In PNI group, significantly shorter PFS OS observed. was shown to be an...
Scarce data are available on the changes in outcomes related to advanced renal cell carcinoma (RCC), from previous tyrosine kinase inhibitor (TKI) era current immuno-oncology (IO) era, among patients IMDC favorable-risk group. Among 618 with previously untreated RCC according our database, 72 classified an International Metastatic Database Consortium (IMDC) favorable risk were selected. These divided into two groups (IO and TKI eras) based treatments recognized as standard of care at time...
The real-world incidence of hepatic dysfunction after combination therapy with cabozantinib plus nivolumab (CABO+NIVO) in Japanese patients metastatic renal cell carcinoma remains undetermined; hence, this study aimed to determine the hepatotoxicity these patients. A total 48 treated CABO+NIVO were enrolled study. Alanine aminotransferase (ALT) levels used evaluate liver because its specificity. ALT elevation any grade was found 30 (63%), and 3 eight (17%). No 4 or 5 elevations observed....
Abstract Background Data regarding long-term outcomes of nivolumab plus ipilimumab for previously untreated advanced renal cell carcinoma (RCC) in real-world patients are limited. Methods This retrospective study evaluated clinical data 66 who received with a minimum 4-years follow-up. Effectiveness and prognosis following deferred cytoreductive nephrectomy (CN) treatment-free interval (TFI), as well safety profiles, were assessed. Results During the follow-up (median 39.7 months), 54 (82%)...
Silencing of genes using small interfering RNA (siRNA) is a recently developed strategy to regulate the synthesis target molecules. Signal transducer and activator transcription 6 (STAT6) nuclear factor that mediates Th2-type immunity.To elucidate therapeutic potential siRNA inhibit STAT6 in allergic reactions, we determined nucleotide sequences specific for STAT6.The selected specifically inhibited generation dermal fibroblasts eotaxin (CCL11) production response IL-4/TNF-α vitro. Local...
Accumulating evidence supporting the cancer stem cell (CSC) hypothesis is based on finding that tumors contain a small population of self-renewing cells generate differentiated progeny and thereby contribute to tumor heterogeneity. CSCs are reported exist in several human cancers, yet only few reports demonstrate existence primary lung dogs. In this study, authors established line derived from canine adenocarcinoma identified side (SP) displayed drug-resistant features. To confirm...
Background/Aim: The impact of the controlling nutritional status (CONUT) score on oncological outcomes after radical cystectomy (RC) for advanced bladder cancer (BC) is unknown. Patients and Methods: We retrospectively evaluated 115 patients who underwent RC BC at our department between November 2003 February 2019. CONUT was calculated from serum albumin levels, total lymphocyte counts, cholesterol levels. Relapse-free survival (RFS), cancer-specific (CSS), overall (OS) were analyzed....
Objective We aimed to examine the effects of isometric handgrip (IHG) training on home blood pressure (BP) levels in hypertensive Japanese patients undergoing treatment.
To explore the therapeutic role of deferred cytoreductive nephrectomy in patients with metastatic renal cell carcinoma treated nivolumab plus ipilimumab.Forty-one synchronous who received ipilimumab as first-line systemic therapy at our affiliated institutions were retrospectively evaluated. We focused on prognosis, including tumor responses primary kidney and lesions nephrectomy. In addition, overall survival according to status (i.e. vs. upfront without nephrectomy) was compared.During a...
The prognostic impact of the administration antibiotics and proton pump inhibitors (PPIs) in immune checkpoint inhibitor (ICI) therapy for advanced cancer has recently been documented. However, how these drugs affect outcomes first-line ICI combination renal cell carcinoma (RCC) remains unclear.
Cancer stem-like cells (CSCs)/cancer-initiating (CICs) are a small subpopulation of cancer that responsible for the initiation, recurrence and metastasis cancer. We previously demonstrated that, using Hoechst 33342 dye-based side population technique, CSCs/CICs in canine lung adenocarcinoma cell line exist. In this study, as known to form spheres anchorage-independent environment vitro, we evaluated stemness spheroid derived from osteosarcoma by expression markers, investigated...
To investigate the prognostic impact of tumor burden in patients receiving nivolumab plus ipilimumab as first-line therapy for previously untreated metastatic renal cell carcinoma (mRCC).We retrospectively evaluated 62 with IMDC intermediate- or poor-risk mRCC, treated at five affiliated institutions. Tumor was defined sum diameters baseline targeted lesions according to RECIST version.1.1. We categorized into two groups based on median value (i.e., high vs. low). The association...
Prognostic impact of sex in patients with malignancies treated immune checkpoint inhibitors has been intensively discussed but remains unclear, especially advanced renal cell carcinoma.We retrospectively evaluated a total 184 carcinoma either nivolumab plus ipilimumab combined treatment as first-line therapy (n = 73) or later-line 111) at our affiliated institutions. Progression-free survival, overall survival and objective response rate well adverse event profile were compared between...