A5055815524- Distributed systems and fault tolerance
- Genetics, Aging, and Longevity in Model Organisms
- Energy Efficient Wireless Sensor Networks
- Distributed and Parallel Computing Systems
- Reproductive tract infections research
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Mobile Agent-Based Network Management
- Advanced Chemical Sensor Technologies
- Gut microbiota and health
- Eicosanoids and Hypertension Pharmacology
- Advanced biosensing and bioanalysis techniques
- Circadian rhythm and melatonin
- Peer-to-Peer Network Technologies
- Bacterial Infections and Vaccines
- IoT and Edge/Fog Computing
- Molecular Biology Techniques and Applications
- Software System Performance and Reliability
- Machine Learning in Bioinformatics
- Advanced Software Engineering Methodologies
- Cervical Cancer and HPV Research
- Air Quality Monitoring and Forecasting
- IPv6, Mobility, Handover, Networks, Security
- Virology and Viral Diseases
- Spaceflight effects on biology
The University of Texas at Austin
2021-2024
Dell Children's Medical Center of Central Texas
2021
Ambedkar University Delhi
2013-2018
University of Delhi
2011-2018
University of California, Davis
2002-2007
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in NOTCH1 that facilitate glutamine oxidation. Here we identify oxidative phosphorylation (OxPhos) as a critical pathway for cell survival and demonstrate direct relationship between , elevated OxPhos gene expression, acquired chemoresistance pre-leukemic leukemic models. Disrupting with IACS-010759, an inhibitor of mitochondrial complex I, causes potent growth inhibition through induction...
With sensor networks expected to be deployed for long periods of time, the ability reprogram them remotely is necessary providing new services, fixing bugs and enhancing applications system software. Given envisioned scales future network deployments, their restricted accessibility limited energy computing resources sensors, transmitting raw binary images inefficient. We present a technique minimize cost application evolution by incrementally linking updated modules at base station...
SIN3, a transcriptional corepressor has been implicated in varied functions both as transcription activator and repressor. Recent studies associated Sin3 with the macroautophagic/autophagic process negative regulator of Atg8 Atg32. Though role SIN3 autophagy is being explored, little known about overall effect deletion on survival an organism. In this study using Caenorhabditis elegans sin-3(tm1279);him-5(e1490) strain, we demonstrate that under vivo conditions SIN-3 differentially modulates...
Stereospecific recognition of metabolites plays a significant role in the detection potential disease biomarkers thereby providing new insights diagnosis and prognosis. D-Hdroxy/amino acids are recognized as several metabolic disorders. Despite continuous advances metabolomics technologies, simultaneous measurement different classes enantiomeric single analytical run remains challenging. Here, we develop novel strategy for untargeted chiral hydroxy/amine groups (−OH/–NH2) containing...
Aging/senescence includes not just decline in lifespan but also etiologies of age associated morbidities which are inadequately understood. Extensive research has been undertaken to delineate the pathways and generate mutants with extended lifespan. However, little is known about health status these long lived background important genetic perturbations. Caenorhabditis elegans one leading vivo model organisms study aging. Deletion SIN-3, a transcription coregulator C. shown reduce mutant...
There is considerable interest in developing runtime infrastructures for programs that can migrate from one host to another. Mobile are appealing because they support efficient utilization of network resources and extensibility information servers. This paper presents a scheduling scheme allocating mix real-time non mobile programs. Within this framework, both hosts specify constraints on how CPU should be allocated. On the basis constraints, constructs graph which it applies several...
Writing distributed programs is difficult. To ease this task, we introduce a new programming abstraction which call mobility attribute. Mobility attributes provide syntax that describes the semantics of program components. Programmers attach to components dynamically control placement these within network. intercept component invocations and decide whether where move before executes. This allows programmer improve her program's runtime efficiency by colocating resources. We present MAGE, an...
User perceived quality is the most important aspect of Internet applications. After a single negative experience, users tend to switch one other myriad alternatives available them on Internet. Two key components application are scalability and reliability. In this paper, we present first general-purpose mechanism capable maintaining reliability in face process, machine, catastrophic failures. We define failures as events that cause entire clusters servers become unavailable such network...
Abstract Background: Glioblastoma (GBM) is a recurrent, chemoresistant, malignant brain tumor. Hypoxia major factor contributing to resistance in GBM which develops due aggressive tumor growth and chronic anti-angiogenic therapy. Thus, under limited oxygen supply it unlikely that the high energy consuming pathways are solely able provide requirement of cells. based on our metabolomics data stated below we hypothesize cells adapt hypoxia utilizing alternate metabolic such as peroxisomal fatty...
There is increasing interest in computing models that support extensibility of systems through code migration. Although appealing both from the system design and points view, extensible are vulnerable to an external program's aberrant execution behaviors. We examine problems resource access control consumption. propose solutions for these analyze their effectiveness.
Although wireless sensor network applications share a common set of limitations (e.g. resource scarcity and lossy radio communication models) basic runtime services routing, time synchronization, code dissemination), are often designed in an ad-hoc fashion, reducing the amount reuse, making component-based software engineering approach desirable. We present micro service component model, entitled muSIC, that abstracts node as entity provides uses services. This model is realized through use...
Dynamic evolution allows designers to move logic from interpreted data structures into directly executed code. This provides the efficiency of code-driven security enforcement without sacrificing flexibility. The Evolvable Systems Project (ESP) at University California, is developing techniques for safely and securely evolve distributed Java applications runtime. We briefly describe design implementation a type-safe model dynamically modifying programs on single host. then how this can be...
Background Intuitive understanding of hypothetical genes’s signal peptide, transmembrane helix (TH) domain and LipoP box any pathogenic microorganisms is a prerequisite for the rational development drugs vaccine candidates. A protein harboring these sequences may serve as receptor conveyer various biostimulations generated during host-pathogen interaction. Identification annotation proteins help in designing novel drug or developing new candidates to control CT infections.
<h3>Introduction</h3> <i>Neisseria gonorrhoeae</i> is an etiologic agent of one the most common sexually transmitted disease in humans. The continuous rise <i>N. infection worldwide accompanied by rapid emergence multidrug-resistant and hypervirulent strains has necessitated search for novel drug targets their inhibitors. present study undertaken to screen inhibitors against N. gonorrhoea. <h3>Methods</h3> putative therapeutic were identified <i>in silico</i> approach which encompassed...
Gene delivery using nonviral approaches has been extensively studied as a basic tool for intracellular gene transfer and therapy. The objective of this work is to comparatively evaluate the expression reporter transgene plasmid DNA encoding green fluorescent protein (EGFP-N1) standard cationic lipid based transfection reagent Lipofectamine. Gelatin, biocompatible biodegradable material, can act non-viral vehicle with low toxicity. Positively charged gelatin microparticles (type B, 75 Bloom)...
Background In India, knowledge regarding N. gonorrhoeae antimicrobial resistance profiling is limited, and data concerning genetic characteristics of also lacking. Herein, we investigated the determinants for various antimicrobials used against isolated in Delhi, India. Various studies have shown that this towards could be either plasmid or chromosomal mediated involving mutations genes. Methods Molecular basis was analysed by amplifying sequencing most target genes, pen A por B,...