A5075536245- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Pancreatic function and diabetes
- Electrohydrodynamics and Fluid Dynamics
- Tissue Engineering and Regenerative Medicine
- Industrial Vision Systems and Defect Detection
- Microencapsulation and Drying Processes
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Pluripotent Stem Cells Research
- Erythrocyte Function and Pathophysiology
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanotechnology research and applications
- Hydrogels: synthesis, properties, applications
- Image and Object Detection Techniques
- Advanced Drug Delivery Systems
- Nanoparticles: synthesis and applications
- Hemoglobin structure and function
- Sustainable Supply Chain Management
- Advanced Thermodynamic Systems and Engines
- Environmental Impact and Sustainability
- Green IT and Sustainability
- Recycling and Waste Management Techniques
- RNA Interference and Gene Delivery
Milwaukee School of Engineering
2016-2025
South China University of Technology
2006-2025
University of Shanghai for Science and Technology
2007-2024
University of South Carolina
2009-2024
Shanghai Jiao Tong University
2024
Heilongjiang Provincial Academy of Agricultural Sciences
2024
Tianjin University of Science and Technology
2023
Beijing University of Technology
2021-2022
Zhejiang Provincial Institute of Communications Planning,Design & Research
2022
Zhejiang University
2016-2021
Tumor reinitiating cancer stem-like cells are responsible for recurrence associated with conventional chemotherapy. We developed a doxorubicin-encapsulated polymeric nanoparticle surface-decorated chitosan that can specifically target the CD44 receptors of these cells. This system was engineered to release doxorubicin in acidic environments, which occurs when nanoparticles localized tumor microenvironment and they internalized cellular endosomes/lysosomes. design strategy increases...
A novel core–shell microcapsule system is developed in this study to mimic the miniaturized 3D architecture of pre-hatching embryos with an aqueous liquid-like core embryonic cells and a hydrogel-shell zona pellucida. This done by microfabricating non-planar microfluidic flow-focusing device that enables one-step generation microcapsules alginate hydrogel shell liquid from two fluids. Mouse stem (ES) encapsulated are found survive well (>92%). Moreover, ~20 ES can proliferate form single...
In this study, we synthesized empty core−shell structured nanocapsules of Pluronic F127 and chitosan characterized the thermal responsiveness in size wall-permeability. Moreover, determined feasibility using to encapsulate small molecules for temperature-controlled release intracellular delivery. The are ∼37 nm at 37 °C expand ∼240 when cooled 4 aqueous solutions, exhibiting >200 times change volume. permeability nanocapsule wall is high (when swollen), allowing free diffusion (ethidium...
We report novel robust resin acid-derived antimicrobial agents that exhibit excellent activities against a broad spectrum of bacteria (6 Gram-positive and 7 Gram-negative) with selective lysis microbial membranes over mammalian membranes. Our results indicate hydrophobicity unique structures acids can be determining factors in dictating the activity.
In this study, we report the preparation of a novel microcapsule ~ 100 μm with liquid (as compared to solid-like alginate hydrogel) core and an alginate-chitosan-alginate (ACA) shell for encapsulation culture embryonic stem (ES) cells in miniaturized 3D space core. Murine R1 ES cultured microcapsules were found survive (> 90%) well proliferate form either single aggregate pluripotent or embryoid body (EB) more differentiated each within 7 days, dependent on medium used. This technology...
We have carried out the synthesis of side-chain rosin-ester-structured poly(ε-caprolactone) (PCL) through a combination ring-opening polymerization and click chemistry. Rosin structures are shown to be effectively incorporated into each repeat unit caprolactone. This simple versatile methodology does not require sophisticated purification raw renewable biomass from nature. The rosin properties been successfully imparted PCL polymers. bulky hydrophenanthrene group increases glass-transition...
A novel coaxial electrospray technology is developed to generate microcapsules with a hydrogel shell of alginate and an aqueous liquid core living cells using two fluids in one step. Approximately 50 murine embryonic stem (ES) encapsulated the high viability (92.3 ± 2.9%) can proliferate form single ES cell aggregate 128.9 17.4 μm each microcapsule within 7 days. Quantitative analyses gene protein expression indicate that cultured miniaturized 3D core-shell have significantly higher...
As an icon of sharing economy and product service systems, bicycle is gaining increasing global popularity, yet there little knowledge about the environmental performance this emerging traveling mode. To seek answer to question, paper employs a survey-based method life cycle assessment (LCA) approach. We first conduct questionnaire-based survey identify changes in modes after introduction shared bicycles. The results show that use bicycles more popular among young low-income populations, are...
A parametric study was performed to understand the effect of preparation parameters on size, morphology, and encapsulation efficiency (i.e., cells/microcapsule) alginate microcapsules prepared using electrostatic spray method. The studied include sodium concentration, voltage, flow rate, cell density. It found that both rate voltage have a significant impact microcapsule size while morphology is greatly influenced by concentration voltage. To obtain small (∼100 μm) cell-loaded with good...
Abstract Pectin, a natural biopolymer mainly derived from citrus fruits and apple peels, shows excellent biodegradable biocompatible properties. This study investigated the electrospinning of pectin-based nanofibers. The parameters, pectin:PEO (polyethylene oxide) ratio, surfactant concentration, voltage, flow rate, were studied to optimize process for generating Oligochitosan, as novel nonionic cross-liker pectin, was also researched. Nanofibers characterized by using AFM, SEM, FTIR...
The thermally responsive wall permeability of an empty core–shell structured Pluronic nanocapsule (together with its temperature dependent size and surface charge) was successfully utilized for encapsulation, intracellular delivery, controlled release trehalose, a highly hydrophilic small (MW = 342 D) molecule (a disaccharide glucose) that is exceptional long-term stabilization biologicals (particularly at ambient temperatures). It found trehalose can be physically encapsulated in the using...
One major challenge of bioprinting is to develop a viable bioink act as an extracellular matrix. This study investigated novel method for using pectin based bioink. Besides pectin, Pluronic® F-127 was incorporated into the obtain desired shape during initial process at 37∘C. Once object printed it treated with Ca2+ (pectin cross-linker) create final tissue/organ structure. The results indicated that pectin/Pluronic® potential Moreover, this methodology provides and fast approach bioprinting.
A major challenge to the eventual success of emerging cell‐based medicine such as tissue engineering, regenerative medicine, and cell transplantation is limited availability desired sources. This can be addressed by microencapsulation overcome undesired immune response (i.e., achieve immunoisolation) so that non‐autologous cells used treat human diseases, cell/tissue preservation bank living for wide distribution end users they are readily available when needed in future. review summarizes...